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dc.contributor.authorAnand, Sonia S
dc.contributor.authorBosch, Jackie
dc.contributor.authorEikelboom, John W
dc.contributor.authorConnolly, Stuart J
dc.contributor.authorDiaz, Rafael
dc.contributor.authorWidimsky, Peter
dc.contributor.authorAboyans, Victor
dc.contributor.authorAlings, Marco
dc.contributor.authorKakkar, Ajay K
dc.contributor.authorKeltai, Katalin
dc.contributor.authorMaggioni, Aldo P
dc.contributor.authorLewis, Basil S
dc.contributor.authorStörk, Stefan
dc.contributor.authorZhu, Jun
dc.contributor.authorLopez-Jaramillo, Patricio
dc.contributor.authorO'Donnell, Martin
dc.contributor.authorCommerford, Patrick J
dc.contributor.authorVinereanu, Dragos
dc.contributor.authorPogosova, Nana
dc.contributor.authorRyden, Lars
dc.contributor.authorFox, Keith A A
dc.contributor.authorBhatt, Deepak L
dc.contributor.authorMisselwitz, Frank
dc.contributor.authorVarigos, John D
dc.contributor.authorVanassche, Thomas
dc.contributor.authorAvezum, Alvaro A
dc.contributor.authorChen, Edmond
dc.contributor.authorBranch, Kelley
dc.contributor.authorLeong, Darryl P
dc.contributor.authorBangdiwala, Shrikant I
dc.contributor.authorHart, Robert G
dc.contributor.authorYusuf, Salim
dc.contributor.authorSALA, JORGELINA
dc.contributor.authorCARTASEGNA, LUIS
dc.contributor.authorVICO, MARISA
dc.contributor.authorHOMINAL, MIGUEL ANGEL
dc.contributor.authorHASBANI, EDUARDO
dc.contributor.authorCACCAVO, ALBERTO
dc.contributor.authorZAIDMAN, CESAR
dc.contributor.authorVOGEL, DANIEL
dc.contributor.authorHRABAR, ADRIAN
dc.contributor.authorSCHYGIEL, PABLO OMAR
dc.contributor.authorCUNEO, CARLOS
dc.contributor.authorLUQUEZ, HUGO
dc.contributor.authorMACKINNON, IGNACIO J.
dc.contributor.authorAHUAD GUERRERO, RODOLFO ANDRES
dc.contributor.authorCOSTABEL, JUAN PABLO
dc.contributor.authorBARTOLACCI, INES PALMIRA
dc.contributor.authorMONTANA, OSCAR
dc.contributor.authorBARBIERI, MARIA
dc.contributor.authorGOMEZ VILAMAJO, OSCAR
dc.contributor.authorGARCIA DURAN, RUBEN OMAR
dc.contributor.authorSCHIAVI, LILIA BEATRIZ
dc.contributor.authorGARRIDO, MARCELO
dc.contributor.authorINGARAMO, ADRIAN
dc.contributor.authorBORDONAVA, ANSELMO PAULINO
dc.contributor.authorPELAGAGGE, MARIA JOSE
dc.contributor.authorNOVARETTO, LEONARDO
dc.contributor.authorALBISU DI GENNERO, JUAN PABLO
dc.contributor.authorIBANEZ SAGGIA, LUZ MARIA
dc.contributor.authorALVAREZ, MOIRA
dc.contributor.authorVITA, NESTOR ALEJANDRO
dc.contributor.authorMACIN, STELLA MARIS
dc.contributor.authorDRAN, RICARDO DARIO
dc.contributor.authorCARDONA, MARCELO
dc.contributor.authorGUZMAN, LUIS
dc.contributor.authorSARJANOVICH, RODOLFO JUAN
dc.contributor.authorCUADRADO, JESUS
dc.contributor.authorNANI, SEBASTIAN
dc.contributor.authorLITVAK BRUNO, MARCOS RAUL
dc.contributor.authorCHACON, CAROLINA
dc.contributor.authorMAFFEI, LAURA ELENA
dc.contributor.authorGRINFELD, DIEGO
dc.contributor.authorVENSENTINI, NATALIA
dc.contributor.authorMAJUL, CLAUDIO RODOLFO
dc.contributor.authorLUCIARDI, HECTOR LUCAS
dc.contributor.authorGONZALEZ COLASO, PATRICIA DEL CARMEN
dc.contributor.authorFERRE PACORA, FREDY ANTONI
dc.contributor.authorVAN DEN HEUVEL, PAUL
dc.contributor.authorVERHAMME, PETER
dc.contributor.authorECTOR, BAVO
dc.contributor.authorDEBONNAIRE, PHILIPPE
dc.contributor.authorVAN DE BORNE, PHILIPPE
dc.contributor.authorLEROY, JEAN
dc.contributor.authorSCHROE, HERMAN
dc.contributor.authorVRANCKX, PASCAL
dc.contributor.authorELEGEERT, IVAN
dc.contributor.authorHOFFER, ETIENNE
dc.contributor.authorDUJARDIN, KARL
dc.contributor.authorINDIO DO BRASIL, CLARISSE
dc.contributor.authorPRECOMA, DALTON
dc.contributor.authorABRANTES, JOSE ANTONIO
dc.contributor.authorMANENTI, EULER
dc.contributor.authorREIS, GILMAR
dc.contributor.authorSARAIVA, JOSE
dc.contributor.authorMAIA, LILIA
dc.contributor.authorHERNANDES, MAURO
dc.contributor.authorROSSI, PAULO
dc.contributor.authorROSSI DOS SANTOS, FABIO
dc.contributor.authorZIMMERMANN, SERGIO LUIZ
dc.contributor.authorRECH, RAFAEL
dc.contributor.authorABIB JR, EDUARDO
dc.contributor.authorLEAES, PAULO
dc.contributor.authorBOTELHO, ROBERTO
dc.contributor.authorDUTRA, OSCAR
dc.contributor.authorSOUZA, WEIMAR
dc.contributor.authorBRAILE, MARIA
dc.contributor.authorIZUKAWA, NILO
dc.contributor.authorNICOLAU, JOSE CARLOS
dc.contributor.authorTANAJURA, LUIZ FERNANDO
dc.contributor.authorSERRANO JUNIOR, CARLOS VICENTE
dc.contributor.authorMINELLI, CESAR
dc.contributor.authorNASI, LUIZ ANTONIO
dc.contributor.authorOLIVEIRA, LIVIA
dc.contributor.authorDE CARVALHO CANTARELLI, MARCELO JOSE
dc.contributor.authorTYTUS, RICHARD
dc.contributor.authorPANDEY, SHEKHAR
dc.contributor.authorLONN, EVA
dc.contributor.authorCHA, JAMES
dc.contributor.authorVIZEL, SAUL
dc.contributor.authorBABAPULLE, MOHAN
dc.contributor.authorLAMY, ANDRE
dc.contributor.authorSAUNDERS, KEVIN
dc.contributor.authorBERLINGIERI, JOSEPH
dc.contributor.authorKIAII, BOB
dc.contributor.authorBHARGAVA, RAKESH
dc.contributor.authorMEHTA, PRAVINSAGAR
dc.contributor.authorHILL, LAURIE
dc.contributor.authorFELL, DAVID
dc.contributor.authorLAM, ANDY
dc.contributor.authorAL-QOOFI, FAISAL
dc.contributor.authorBROWN, CRAIG
dc.contributor.authorPETRELLA, ROBERT
dc.contributor.authorRICCI, JOSEPH A
dc.contributor.authorGLANZ, ANTHONY
dc.contributor.authorNOISEUX, NICOLAS
dc.contributor.authorBAINEY, KEVIN
dc.contributor.authorMERALI, FATIMA
dc.contributor.authorHEFFERNAN, MICHAEL
dc.contributor.authorDELLA SIEGA, ANTHONY
dc.contributor.authorDAGENAIS, GILLES R
dc.contributor.authorDAGENAIS, FRANCOIS
dc.contributor.authorBRULOTTE, STEEVE
dc.contributor.authorNGUYEN, MICHEL
dc.contributor.authorHARTLEIB, MICHAEL
dc.contributor.authorGUZMAN, RANDOLPH
dc.contributor.authorBOURGEOIS, RONALD
dc.contributor.authorRUPKA, DENNIS
dc.contributor.authorKHAYKIN, YAARIV
dc.contributor.authorGOSSELIN, GILBERT
dc.contributor.authorHUYNH, THAO
dc.contributor.authorPILON, CLAUDE
dc.contributor.authorCAMPEAU, JEAN
dc.contributor.authorPICHETTE, FRANCIS
dc.contributor.authorDIAZ, ARIEL
dc.contributor.authorJOHNSTON, JAMES
dc.contributor.authorSHUKLE, PRAVIN
dc.contributor.authorHIRSCH, GREGORY
dc.contributor.authorRHEAULT, PAUL
dc.contributor.authorCZARNECKI, WLODZIMIERZ
dc.contributor.authorROY, ANNIE
dc.contributor.authorNAWAZ, SHAH
dc.contributor.authorFREMES, STEPHEN
dc.contributor.authorSHUKLA, DINKAR
dc.contributor.authorJANO, GABRIEL
dc.contributor.authorCOBOS, JORGE LEONARDO
dc.contributor.authorCORBALAN, RAMON
dc.contributor.authorMEDINA, MARCELO
dc.contributor.authorNAHUELPAN, LEONARDO
dc.contributor.authorRAFFO, CARLOS
dc.contributor.authorPEREZ, LUIS
dc.contributor.authorPOTTHOFF, SERGIO
dc.contributor.authorSTOCKINS, BENJAMIN
dc.contributor.authorSEPULVEDA, PABLO
dc.contributor.authorPINCETTI, CHRISTIAN
dc.contributor.authorVEJAR, MARGARITA
dc.contributor.authorTIAN, HONGYAN
dc.contributor.authorWU, XUESI
dc.contributor.authorKE, YUANNAN
dc.contributor.authorJIA, KAIYING
dc.contributor.authorYIN, PENGFEI
dc.contributor.authorWANG, ZHAOHUI
dc.contributor.authorYU, LITIAN
dc.contributor.authorWU, SHULIN
dc.contributor.authorWU, ZONGQUI
dc.contributor.authorLIU, SHAO WEN
dc.contributor.authorBAI, XIAO JUAN
dc.contributor.authorZHENG, YANG
dc.contributor.authorYANG, PING
dc.contributor.authorYANG, YUN MEI
dc.contributor.authorZHANG, JIWEI
dc.contributor.authorGE, JUNBO
dc.contributor.authorCHEN, XIAO PING
dc.contributor.authorLI, JUNXIA
dc.contributor.authorHU, TAO HONG
dc.contributor.authorZHANG, RUIYAN
dc.contributor.authorZHENG, ZHE
dc.contributor.authorCHEN, XIN
dc.contributor.authorTAO, LIANG
dc.contributor.authorLI, JIANPING
dc.contributor.authorHUANG, WEIJIAN
dc.contributor.authorFU, GUOSHENG
dc.contributor.authorLI, CHUNJIAN
dc.contributor.authorDONG, YUGANG
dc.contributor.authorWANG, CHUNSHENG
dc.contributor.authorZHOU, XINMIN
dc.contributor.authorKONG, YE
dc.contributor.authorSOTOMAYOR, ARISTIDES
dc.contributor.authorACCINI MENDOZA, JOSE LUIS
dc.contributor.authorCASTILLO, HENRY
dc.contributor.authorURINA, MIGUEL
dc.contributor.authorAROCA, GUSTAVO
dc.contributor.authorPEREZ, MARITZA
dc.contributor.authorMOLINA DE SALAZAR, DORA INES
dc.contributor.authorSANCHEZ VALLEJO, GREGORIO
dc.contributor.authorMANZUR J, FERNANDO
dc.contributor.authorGARCIA, HENRY
dc.contributor.authorGARCIA, LUIS HERNANDO
dc.contributor.authorARCOS, EDGAR
dc.contributor.authorGOMEZ, JUAN
dc.contributor.authorCUERVO MILLAN, FRANCISCO
dc.contributor.authorTRUJILLO DADA, FREDY ALBERTO
dc.contributor.authorVESGA, BORIS
dc.contributor.authorMORENO SILGADO, GUSTAVO ADOLFO
dc.contributor.authorZIDKOVA, EVA
dc.contributor.authorLUBANDA, JEAN-CLAUDE
dc.contributor.authorKALETOVA, MARKETA
dc.contributor.authorKRYZA, RADIM
dc.contributor.authorMARCINEK, GABRIEL
dc.contributor.authorRICHTER, MAREK
dc.contributor.authorSPINAR, JINDRICH
dc.contributor.authorMATUSKA, JIRI
dc.contributor.authorTESAK, MARTIN
dc.contributor.authorMOTOVSKA, ZUZANA
dc.contributor.authorBRANNY, MARIAN
dc.contributor.authorMALY, JIRI
dc.contributor.authorMALY, MARTIN
dc.contributor.authorWIENDL, MARTIN
dc.contributor.authorFOLTYNOVA CAISOVA, LENKA
dc.contributor.authorSLABY, JOSEF
dc.contributor.authorVOJTISEK, PETR
dc.contributor.authorPIRK, JAN
dc.contributor.authorSPINAROVA, LENKA
dc.contributor.authorBENESOVA, MIROSLAVA
dc.contributor.authorCANADYOVA, JULIA
dc.contributor.authorHOMZA, MIROSLAV
dc.contributor.authorFLORIAN, JINDRICH
dc.contributor.authorPOLASEK, ROSTISLAV
dc.contributor.authorCOUFAL, ZDENEK
dc.contributor.authorSKALNIKOVA, VLADIMIRA
dc.contributor.authorBRAT, RADIM
dc.contributor.authorBRTKO, MIROSLAV
dc.contributor.authorJANSKY, PETR
dc.contributor.authorLINDNER, JAROSLAV
dc.contributor.authorMARCIAN, PAVEL
dc.contributor.authorSTRAKA, ZBYNEK
dc.contributor.authorTRETINA, MARTIN
dc.contributor.authorDUARTE, YAN CARLOS
dc.contributor.authorPOW CHON LONG, FREDDY
dc.contributor.authorSANCHEZ, MAYRA
dc.contributor.authorLOPEZ, JOSE
dc.contributor.authorPERUGACHI, CARMITA
dc.contributor.authorMARMOL, RICARDO
dc.contributor.authorTRUJILLO, FREDDY
dc.contributor.authorTERAN, PABLO
dc.contributor.authorTUOMILEHTO, JAAKKO
dc.contributor.authorTUOMILEHTO, HENRI
dc.contributor.authorTUOMINEN, MARJA-LEENA
dc.contributor.authorTUOMILEHTO, HENRI
dc.contributor.authorKANTOLA, ILKKA
dc.contributor.authorSTEG, GABRIEL
dc.contributor.authorABOYANS, VICTOR
dc.contributor.authorLECLERCQ, FLORENCE
dc.contributor.authorFERRARI, EMILE
dc.contributor.authorBOCCARA, FRANCK
dc.contributor.authorMESSAS, EMMANUEL
dc.contributor.authorMISMETTI, PATRICK
dc.contributor.authorSEVESTRE, MARIE ANTOINETTE
dc.contributor.authorCAYLA, GUILLAUME
dc.contributor.authorMOTREFF, PASCAL
dc.contributor.authorSTOERK, STEFAN
dc.contributor.authorDUENGEN, HANS-DIRK
dc.contributor.authorSTELLBRINK, CHRISTOPH
dc.contributor.authorGUEROCAK, OSMAN
dc.contributor.authorKADEL, CHRISTOPH
dc.contributor.authorBRAUN-DULLAEUS, RUEDIGER
dc.contributor.authorJESERICH, MICHAEL
dc.contributor.authorOPITZ, CHRISTIAN
dc.contributor.authorVOEHRINGER, HANS-FRIEDRICH
dc.contributor.authorAPPEL, KARL-FRIEDRICH
dc.contributor.authorWINKELMANN, BERNHARD
dc.contributor.authorDORSEL, THOMAS
dc.contributor.authorNIKOL, SIGRID
dc.contributor.authorDARIUS, HARALD
dc.contributor.authorRANFT, JURGEN
dc.contributor.authorSCHELLONG, SEBASTIAN
dc.contributor.authorJUNGMAIR, WOLFGANG
dc.contributor.authorDAVIERWALA, PIROZE
dc.contributor.authorVORPAHL, MARC
dc.contributor.authorBAJNOK, LASZLO
dc.contributor.authorLASZLO, ZOLTAN
dc.contributor.authorNOORI, EBRAHIM
dc.contributor.authorVERESS, GABOR
dc.contributor.authorVERTES, ANDRAS
dc.contributor.authorZSARY, ANDRAS
dc.contributor.authorKIS, ERNO
dc.contributor.authorKORANYI, LASZLO
dc.contributor.authorBAKAI, JUDIT
dc.contributor.authorBODA, ZOLTAN
dc.contributor.authorPOOR, FERENC
dc.contributor.authorJARAI, ZOLTAN
dc.contributor.authorKEMENY, VENDEL
dc.contributor.authorBARTON, JOHN
dc.contributor.authorMCADAM, BRENDAN
dc.contributor.authorMURPHY, ANDREW
dc.contributor.authorCREAN, PETER
dc.contributor.authorMAHON, NIALL
dc.contributor.authorCURTIN, RONAN
dc.contributor.authorMACNEILL, BRIAIN
dc.contributor.authorDINNEEN, SEAN
dc.contributor.authorHALABI, MAJDI
dc.contributor.authorZIMLICHMAN, REUVEN
dc.contributor.authorZELTSER, DAVID
dc.contributor.authorTURGEMAN, YOAV
dc.contributor.authorKLAINMAN, ELIEZER
dc.contributor.authorLEWIS, BASIL
dc.contributor.authorKATZ, AMOS
dc.contributor.authorATAR, SHAUL
dc.contributor.authorZIMLICHMAN, REUVEN
dc.contributor.authorNIKOLSKY, EUGENIA
dc.contributor.authorBOSI, STEFANO
dc.contributor.authorNALDI, MONICA
dc.contributor.authorFAGGIANO, POMPILIO
dc.contributor.authorROBBA, DEBORA
dc.contributor.authorMOS, LUCIO
dc.contributor.authorSINAGRA, GIANFRANCO
dc.contributor.authorCOSMI, FRANCO
dc.contributor.authorOLTRONA VISCONTI, LUIGI
dc.contributor.authorCARMINE, DE MATTEIS
dc.contributor.authorDI PASQUALE, GIUSEPPE
dc.contributor.authorDI BIASE, MATTEO
dc.contributor.authorMANDORLA, SARA
dc.contributor.authorBERNARDINANGELI, MARINO
dc.contributor.authorPICCINNI, GIOVANNI CARLO
dc.contributor.authorGULIZIA, MICHELE MASSIMO
dc.contributor.authorGALVANI, MARCELLO
dc.contributor.authorVENTURI, FLAVIO
dc.contributor.authorMOROCUTTI, GIORGIO
dc.contributor.authorBALDIN, MARIA GRAZIA
dc.contributor.authorOLIVIERI, CARLO
dc.contributor.authorPERNA, GIAN PIERO
dc.contributor.authorCIRRINCIONE, VINCENZO
dc.contributor.authorKANNO, TAKAYASU
dc.contributor.authorDAIDA, HIROYUKI
dc.contributor.authorOZAKI, YUKIO
dc.contributor.authorMIYAMOTO, NAOMASA
dc.contributor.authorHIGASHIUE, SHINICHI
dc.contributor.authorDOMAE, HIROSHI
dc.contributor.authorHOSOKAWA, SHINOBU
dc.contributor.authorKOBAYASHI, HIROO
dc.contributor.authorKURAMOCHI, TAKEHIKO
dc.contributor.authorFUJII, KENSHI
dc.contributor.authorMIZUTOMI, KAZUAKI
dc.contributor.authorSAKU, KEIJIRO
dc.contributor.authorKIMURA, KAZUO
dc.contributor.authorHIGUCHI, YOSHIHARU
dc.contributor.authorABE, MITSUNORI
dc.contributor.authorOKUDA, HARUHITO
dc.contributor.authorNODA, TOSHIYUKI
dc.contributor.authorMITA, TERUAKI
dc.contributor.authorHIRAYAMA, ATSUSHI
dc.contributor.authorONAKA, HARUHIKO
dc.contributor.authorINOKO, MORIAKI
dc.contributor.authorHIROKAMI, MITSUGU
dc.contributor.authorOKUBO, MUNENORI
dc.contributor.authorAKATSUKA, YUTAKA
dc.contributor.authorIMAMAKI, MIZUHO
dc.contributor.authorKAMIYA, HARUO
dc.contributor.authorMANITA, MAMORU
dc.contributor.authorHIMI, TOSHIHARU
dc.contributor.authorUENO, HIDEKI
dc.contributor.authorHISAMATSU, YUJI
dc.contributor.authorAKO, JUNYA
dc.contributor.authorNISHINO, YASUHIRO
dc.contributor.authorKAWAKAMI, HIDEO
dc.contributor.authorYAMADA, YUTAKA
dc.contributor.authorKORETSUNE, YUKIHIRO
dc.contributor.authorYAMADA, TAKAHISA
dc.contributor.authorYOSHIDA, TETSURO
dc.contributor.authorSHIMOMURA, HIDEKI
dc.contributor.authorKINOSHITA, NORIYUKI
dc.contributor.authorTAKAHASHI, AKIHIKO
dc.contributor.authorYUSOFF, KHALID
dc.contributor.authorWAN AHMAD, WAN AZMAN
dc.contributor.authorABU HASSAN, MUHAMMAD RADZI
dc.contributor.authorKASIM, SAZZLI
dc.contributor.authorABDUL RAHIM, AIZAI AZAN
dc.contributor.authorMOHD ZAMRIN, DIMON
dc.contributor.authorMACHIDA, MASAHARU
dc.contributor.authorHIGASHINO, YORIHIKO
dc.contributor.authorUTSU, NORIAKI
dc.contributor.authorNAKANO, AKIHIKO
dc.contributor.authorNAKAMURA, SHIGERU
dc.contributor.authorHASHIMOTO, TETSUO
dc.contributor.authorANDO, KENJI
dc.contributor.authorSAKAMOTO, TOMOHIRO
dc.contributor.authorPRINS, F.J.
dc.contributor.authorLOK, DIRK
dc.contributor.authorMILHOUS, JOHANNES GERT-JAN
dc.contributor.authorVIERGEVER, ERIC
dc.contributor.authorWILLEMS, FRANK
dc.contributor.authorSWART, HENK
dc.contributor.authorALINGS, MARCO
dc.contributor.authorBREEDVELD, ROB
dc.contributor.authorDE VRIES, KEES-JAN
dc.contributor.authorVAN DER BORGH, ROGER
dc.contributor.authorOEI, FANNY
dc.contributor.authorZOET-NUGTEREN, STIENEKE
dc.contributor.authorKRAGTEN, HANS
dc.contributor.authorHERRMAN, JEAN PAUL
dc.contributor.authorVAN BERGEN, PAUL
dc.contributor.authorGOSSELINK, MARCEL
dc.contributor.authorHOEKSTRA, EDUARD
dc.contributor.authorZEGERS, ERWIN
dc.contributor.authorRONNER, EELKO
dc.contributor.authorDEN HARTOG, FRANK
dc.contributor.authorBARTELS, GERARD
dc.contributor.authorNIEROP, PETER
dc.contributor.authorVAN DER ZWAAN, COEN
dc.contributor.authorVAN ECK, JACOB
dc.contributor.authorVAN GORSELEN, EDWIN
dc.contributor.authorGROENEMEIJER, BJORN
dc.contributor.authorHOOGSLAG, PIETER
dc.contributor.authorDE GROOT, MARC ROBERT
dc.contributor.authorLOYOLA, ALDRIN
dc.contributor.authorSULIT, DENNIS JOSE
dc.contributor.authorREY, NANNETTE
dc.contributor.authorABOLA, MARIA TERESA
dc.contributor.authorMORALES, DANTE
dc.contributor.authorPALOMARES, ELLEN
dc.contributor.authorABAT, MARC EVANS
dc.contributor.authorROGELIO, GREGORIO
dc.contributor.authorCHUA, PHILIP
dc.contributor.authorDEL PILAR, JOSE CARLO
dc.contributor.authorALCARAZ, JOHN DENNIS
dc.contributor.authorEBO, GERALDINE
dc.contributor.authorTIRADOR, LOUIE
dc.contributor.authorCRUZ, JOSEFINA
dc.contributor.authorANONUEVO, JOHN
dc.contributor.authorPITARGUE, ARTHUR
dc.contributor.authorJANION, MARIANNA
dc.contributor.authorGUZIK, TOMASZ
dc.contributor.authorGAJOS, GRZEGORZ
dc.contributor.authorZABOWKA, MACIEJ
dc.contributor.authorRYNKIEWICZ, ANDRZEJ
dc.contributor.authorBRONCEL, MARLENA
dc.contributor.authorSZUBA, ANDRZEJ
dc.contributor.authorCZARNECKA, DANUTA
dc.contributor.authorMAGA, PAWEL
dc.contributor.authorSTRAZHESKO, IRINA
dc.contributor.authorVASYUK, YURY
dc.contributor.authorSIZOVA, ZHANNA
dc.contributor.authorPOZDNYAKOV, YURY
dc.contributor.authorBARBARASH, OLGA
dc.contributor.authorVOEVODA, MIKHAIL
dc.contributor.authorPOPONINA, TATIANA
dc.contributor.authorREPIN, ALEXEY
dc.contributor.authorOSIPOVA, IRINA
dc.contributor.authorEFREMUSHKINA, ANNA
dc.contributor.authorNOVIKOVA, NINA
dc.contributor.authorAVERKOV, OLEG
dc.contributor.authorZATEYSHCHIKOV, DMITRY
dc.contributor.authorVERTKIN, ARKADIY
dc.contributor.authorAUSHEVA, AZA
dc.contributor.authorCOMMERFORD, PATRICK
dc.contributor.authorSEEDAT, SAADIYA
dc.contributor.authorVAN ZYL, LOUIS
dc.contributor.authorENGELBRECHT, JAN
dc.contributor.authorMAKOTOKO, ELLEN MAKONLI
dc.contributor.authorPRETORIUS, CATHARINA ELIZABETH
dc.contributor.authorMOHAMED, ZAID
dc.contributor.authorHORAK, ADRIAN
dc.contributor.authorMABIN, THOMAS
dc.contributor.authorKLUG, ERIC
dc.contributor.authorBAE, JANG-HO
dc.contributor.authorKIM, CHEOLHO
dc.contributor.authorKIM, CHONG-JIN
dc.contributor.authorKIM, DONG-SOO
dc.contributor.authorKIM, YONG JIN
dc.contributor.authorJOO, SEUNGJAE
dc.contributor.authorHA, JONG-WON
dc.contributor.authorPARK, CHUL SOO
dc.contributor.authorKIM, JANG YOUNG
dc.contributor.authorKIM, YOUNG-KWON
dc.contributor.authorJARNERT, CHRISTINA
dc.contributor.authorMOOE, THOMAS
dc.contributor.authorDELLBORG, MIKAEL
dc.contributor.authorTORSTENSSON, INGEMAR
dc.contributor.authorALBERTSSON, PER
dc.contributor.authorJOHANSSON, LARS
dc.contributor.authorAL-KHALILI, FARIS
dc.contributor.authorALMROTH, HENRIK
dc.contributor.authorANDERSSON, TOMMY
dc.contributor.authorPANTEV, EMIL
dc.contributor.authorTENGMARK, BENGT-OLOV
dc.contributor.authorLIU, BO
dc.contributor.authorRASMANIS, GUNDARS
dc.contributor.authorWAHLGREN, CARL-MAGNUS
dc.contributor.authorMOCCETTI, TIZIANO
dc.contributor.authorPARKHOMENKO, ALEXANDER
dc.contributor.authorTSELUYKO, VIRA
dc.contributor.authorVOLKOV, VOLODYMYR
dc.contributor.authorKOVAL, OLENA
dc.contributor.authorKONONENKO, LYUDMYLA
dc.contributor.authorPROKHOROV, OLEKSANDR
dc.contributor.authorVDOVYCHENKO, VALERIY
dc.contributor.authorBAZYLEVYCH, ANDRIY
dc.contributor.authorRUDENKO, LEONID
dc.contributor.authorVIZIR, VADYM
dc.contributor.authorKARPENKO, OLEKSANDR
dc.contributor.authorMALYNOVSKY, YAROSLAV
dc.contributor.authorKOVAL, VALENTYNA
dc.contributor.authorSTOROZHUK, BORYS
dc.contributor.authorCOTTON, JAMES
dc.contributor.authorVENKATARAMAN, ASOK
dc.contributor.authorMORIARTY, ANDREW
dc.contributor.authorCONNOLLY, DEREK
dc.contributor.authorDAVEY, PATRICK
dc.contributor.authorSENIOR, ROXY
dc.contributor.authorBIRDI, INDERPAUL
dc.contributor.authorCALVERT, JOHN
dc.contributor.authorDONNELLY, PATRICK
dc.contributor.authorTREVELYAN, JASPER
dc.contributor.authorCARTER, JUSTIN
dc.contributor.authorPEACE, AARON
dc.contributor.authorAUSTIN, DAVID
dc.contributor.authorKUKREJA, NEVILLE
dc.contributor.authorHILTON, THOMAS
dc.contributor.authorSRIVASTAVA, SUNNY
dc.contributor.authorWALSH, RONALD
dc.contributor.authorFIELDS, RONALD
dc.contributor.authorHAKAS, JOSEPH
dc.contributor.authorPORTNAY, EDWARD
dc.contributor.authorGOGIA, HARINDER
dc.contributor.authorSALACATA, ABRAHAM
dc.contributor.authorHUNTER, JOHN J.
dc.contributor.authorBACHARACH, J MICHAEL
dc.contributor.authorSHAMMAS, NICOLAS
dc.contributor.authorSURESH, DAMODHAR
dc.contributor.authorSCHNEIDER, RICKY
dc.contributor.authorGURBEL, PAUL
dc.contributor.authorBANERJEE, SUBHASH
dc.contributor.authorGRENA, PAUL
dc.contributor.authorBEDWELL, NOEL
dc.contributor.authorSLOAN, STEPHEN
dc.contributor.authorLUPOVITCH, STEVEN
dc.contributor.authorSONI, ANAND
dc.contributor.authorGIBSON, KATHLEEN
dc.contributor.authorSANGRIGOLI, RENEE
dc.contributor.authorMEHTA, RAJENDRA
dc.contributor.authorI-HSUAN TSAI, PETER
dc.contributor.authorGILLESPIE, EVE
dc.contributor.authorDEMPSEY, STEPHEN
dc.contributor.authorHAMROFF, GLENN
dc.contributor.authorBLACK, ROBERT
dc.contributor.authorLADER, ELLIS
dc.contributor.authorKOSTIS, JOHN B.
dc.contributor.authorBITTNER, VERA
dc.contributor.authorMCGUINN, WILLIAM
dc.contributor.authorBRANCH, KELLEY
dc.contributor.authorMALHOTRA, VINAY
dc.contributor.authorMICHAELSON, STEPHEN
dc.contributor.authorVACANTE, MICHAEL
dc.contributor.authorMCCORMICK, MATTHEW
dc.contributor.authorARIMIE, RALUCA
dc.contributor.authorCAMP, ALAN
dc.contributor.authorDAGHER, GEORGE
dc.contributor.authorKOSHY, N. MATHEW
dc.contributor.authorTHEW, STEPHEN
dc.contributor.authorCOSTELLO, FREDERICK
dc.contributor.authorHEIMAN, MARK
dc.contributor.authorCHILTON, ROBERT
dc.contributor.authorMORAN, MICHAEL
dc.contributor.authorADLER, FREDRIC
dc.contributor.authorCOMEROTA, ANTHONY
dc.contributor.authorSEIWERT, ANDREW
dc.contributor.authorFRENCH, WILLIAM
dc.contributor.authorSEROTA, HARVEY
dc.contributor.authorHARRISON, ROBERT
dc.contributor.authorBAKAEEN, FAISAL
dc.contributor.authorOMER, SHUAB
dc.contributor.authorCHANDRA, LOKESH
dc.contributor.authorWHELAN, ALAN
dc.contributor.authorBOYLE, ANDREW
dc.contributor.authorROBERTS-THOMSON, PHILIP
dc.contributor.authorROGERS, JAMES
dc.contributor.authorCARROLL, PATRICK
dc.contributor.authorCOLQUHOUN, DAVID
dc.contributor.authorSHAW, JAMES
dc.contributor.authorBLOMBERY, PETER
dc.contributor.authorAMERENA, JOHN
dc.contributor.authorHII, CHRIS
dc.contributor.authorROYSE, ALISTAIR
dc.contributor.authorSINGH, BHUWAN
dc.contributor.authorSELVANAYAGAM, JOSEPH
dc.contributor.authorJANSEN, SHIRLEY
dc.contributor.authorLO, WINGCHI
dc.contributor.authorHAMMETT, CHRISTOPHER
dc.contributor.authorPOULTER, ROHAN
dc.contributor.authorNARASIMHAN, SESHASAYEE
dc.contributor.authorWIGGERS, HENRIK
dc.contributor.authorNIELSEN, HENRIK
dc.contributor.authorGISLASON, GUNNAR
dc.contributor.authorKOBER, LARS
dc.contributor.authorHOULIND, KIM
dc.contributor.authorBOENELYKKE SOERENSEN, VIBEKE
dc.contributor.authorDIXEN, ULRIK
dc.contributor.authorREFSGAARD, JENS
dc.contributor.authorZEUTHEN, ELISABETH
dc.contributor.authorSOEGAARD, PETER
dc.contributor.authorHRANAI, MARIAN
dc.contributor.authorGASPAR, LUDOVIT
dc.contributor.authorPELLA, DANIEL
dc.contributor.authorHATALOVA, KATARINA
dc.contributor.authorDROZDAKOVA, ERIKA
dc.contributor.authorCOMAN, IOAN
dc.contributor.authorDIMULESCU, DOINA
dc.contributor.authorVINEREANU, DRAGOS
dc.contributor.authorCINTEZA, MIRCEA
dc.contributor.authorSINESCU, CRINA
dc.contributor.authorARSENESCU, CATALINA
dc.contributor.authorBENEDEK, IMRE
dc.contributor.authorBOBESCU, ELENA
dc.contributor.authorDOBREANU, DAN
dc.contributor.authorGAITA, DAN
dc.contributor.authorIANCU, ADRIAN
dc.contributor.authorILIESIU, ADRIANA
dc.contributor.authorLIGHEZAN, DANIEL
dc.contributor.authorPETRESCU, LUCIAN
dc.contributor.authorPIRVU, OCTAVIAN
dc.contributor.authorTEODORESCU, IULIA
dc.contributor.authorTESLOIANU, DAN
dc.contributor.authorVINTILA, MARIUS MARCIAN
dc.contributor.authorCHIONCEL, OVIDIU
dc.date.accessioned2018-09-20T15:59:46Z
dc.date.available2018-09-20T15:59:46Z
dc.date.issued2017-11-01
dc.identifier.citationAnand, Sonia S; Bosch, Jackie; Eikelboom, John W; Connolly, Stuart J; Diaz, Rafael; Widimsky, Peter; Aboyans, Victor; Alings, Marco; Kakkar, Ajay K; Keltai, Katalin; Maggioni, Aldo P; Lewis, Basil S; Störk, Stefan; Zhu, Jun; Lopez-Jaramillo, Patricio; O'Donnell, Martin; Commerford, Patrick J; Vinereanu, Dragos; Pogosova, Nana; Ryden, Lars; Fox, Keith A A; Bhatt, Deepak L; Misselwitz, Frank; Varigos, John D; Vanassche, Thomas; Avezum, Alvaro A; Chen, Edmond; Branch, Kelley; Leong, Darryl P; Bangdiwala, Shrikant I; Hart, Robert G; Yusuf, Salim; SALA, JORGELINA; CARTASEGNA, LUIS; VICO, MARISA; HOMINAL, MIGUEL ANGEL; HASBANI, EDUARDO; CACCAVO, ALBERTO; ZAIDMAN, CESAR; VOGEL, DANIEL; HRABAR, ADRIAN; SCHYGIEL, PABLO OMAR; CUNEO, CARLOS; LUQUEZ, HUGO; MACKINNON, IGNACIO J. AHUAD GUERRERO, RODOLFO ANDRES; COSTABEL, JUAN PABLO; BARTOLACCI, INES PALMIRA; MONTANA, OSCAR; BARBIERI, MARIA; GOMEZ VILAMAJO, OSCAR; GARCIA DURAN, RUBEN OMAR; SCHIAVI, LILIA BEATRIZ; GARRIDO, MARCELO; INGARAMO, ADRIAN; BORDONAVA, ANSELMO PAULINO; PELAGAGGE, MARIA JOSE; NOVARETTO, LEONARDO; ALBISU DI GENNERO, JUAN PABLO; IBANEZ SAGGIA, LUZ MARIA; ALVAREZ, MOIRA; VITA, NESTOR ALEJANDRO; MACIN, STELLA MARIS; DRAN, RICARDO DARIO; CARDONA, MARCELO; GUZMAN, LUIS; SARJANOVICH, RODOLFO JUAN; CUADRADO, JESUS; NANI, SEBASTIAN; LITVAK BRUNO, MARCOS RAUL; CHACON, CAROLINA; MAFFEI, LAURA ELENA; GRINFELD, DIEGO; VENSENTINI, NATALIA; MAJUL, CLAUDIO RODOLFO; LUCIARDI, HECTOR LUCAS; GONZALEZ COLASO, PATRICIA DEL CARMEN; FERRE PACORA, FREDY ANTONI; VAN DEN HEUVEL, PAUL; VERHAMME, PETER; ECTOR, BAVO; DEBONNAIRE, PHILIPPE; VAN DE BORNE, PHILIPPE; LEROY, JEAN; SCHROE, HERMAN; VRANCKX, PASCAL; ELEGEERT, IVAN; HOFFER, ETIENNE; DUJARDIN, KARL; INDIO DO BRASIL, CLARISSE; PRECOMA, DALTON; ABRANTES, JOSE ANTONIO; 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dc.identifier.issn0140-6736
dc.identifier.urihttp://hdl.handle.net/10379/10246
dc.description.abstractBackground Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. Methods This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0.90. After a 30-day run-in period, patients were randomly assigned (1:1:1) to receive oral rivaroxaban (2.5 mg twice a day) plus aspirin (100 mg once a day), rivaroxaban twice a day (5 mg with aspirin placebo once a day), or to aspirin once a day (100 mg and rivaroxaban placebo twice a day). Randomisation was computer generated. Each treatment group was double dummy, and the patient, investigators, and central study staff were masked to treatment allocation. The primary outcome was cardiovascular death, myocardial infarction or stroke; the primary peripheral artery disease outcome was major adverse limb events including major amputation. This trial is registered with ClinicalTrials.gov, number NCT01776424, and is closed to new participants. Findings Between March 12, 2013, and May 10, 2016, we enrolled 7470 patients with peripheral artery disease from 558 centres. The combination of rivaroxaban plus aspirin compared with aspirin alone reduced the composite endpoint of cardiovascular death, myocardial infarction, or stroke (126 [5%] of 2492 vs 174 [7%] of 2504; hazard ratio [HR] 0.72, 95% CI 0.57-0.90, p=0.0047), and major adverse limb events including major amputation (32 [1%] vs 60 [2%]; HR 0.54 95% CI 0.35-0.82, p=0.0037). Rivaroxaban 5 mg twice a day compared with aspirin alone did not significantly reduce the composite endpoint (149 [6%] of 2474 vs 174 [7%] of 2504; HR 0.86, 95% CI 0.69-1.08, p=0.19), but reduced major adverse limb events including major amputation (40 [2%] vs 60 [2%]; HR 0.67, 95% CI 0.45-1.00, p=0.05). The median duration of treatment was 21 months. The use of the rivaroxaban plus aspirin combination increased major bleeding compared with the aspirin alone group (77 [3%] of 2492 vs 48 [2%] of 2504; HR 1.61, 95% CI 1.12-2.31, p=0.0089), which was mainly gastrointestinal. Similarly, major bleeding occurred in 79 (3%) of 2474 patients with rivaroxaban 5 mg, and in 48 (2%) of 2504 in the aspirin alone group (HR 1.68, 95% CI 1.17-2.40; p=0.0043). Interpretation Low-dose rivaroxaban taken twice a day plus aspirin once a day reduced major adverse cardiovascular and limb events when compared with aspirin alone. Although major bleeding was increased, fatal or critical organ bleeding was not. This combination therapy represents an important advance in the management of patients with peripheral artery disease. Rivaroxaban alone did not significantly reduce major adverse cardiovascular events compared with asprin alone, but reduced major adverse limb events and increased major bleeding.
dc.publisherElsevier BV
dc.relation.ispartofThe Lancet
dc.subjectcardiovascular event rates
dc.subjectlower-extremity amputation
dc.subjectatrial-fibrillation
dc.subjectprevention
dc.subjectrisk
dc.subjectatherothrombosis
dc.subjectmetaanalysis
dc.subjectoutpatients
dc.subjectguidelines
dc.subjectmanagement
dc.titleRivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial
dc.typeArticle
dc.identifier.doi10.1016/s0140-6736(17)32409-1
dc.local.publishedsourcehttp://www.zora.uzh.ch/id/eprint/145883/1/Rivaroxaban_with_or_without_ASA_2.pdf
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