Browsing Externally hosted open access publications with University of Galway authors (2) by Subject "cag repeat"
Now showing items 1-2 of 2
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Mutsβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells
(Oxford University Press (OUP), 2012-08-30)Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington's disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. ... -
Trinucleotide repeat expansions catalyzed by human cell-free extracts
(Springer Nature, 2013-01-22)Trinucleotide repeat expansions cause 17 heritable human neurological disorders. In some diseases, somatic expansions occur in non-proliferating tissues such as brain where DNA replication is limited. This finding stimulated ...