Now showing items 1-2 of 2

    • Mutsβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells 

      Gannon, Anne-Marie M.; Frizzell, Aisling; Healy, Evan; Lahue, Robert S. (Oxford University Press (OUP), 2012-08-30)
      Trinucleotide repeat (TNR) expansions cause at least 17 heritable neurological diseases, including Huntington's disease. Expansions are thought to arise from abnormal processing of TNR DNA by specific trans-acting proteins. ...
    • Trinucleotide repeat expansions catalyzed by human cell-free extracts 

      Stevens, Jennifer R; Lahue, Elaine E; Li, Guo-Min; Lahue, Robert S (Springer Nature, 2013-01-22)
      Trinucleotide repeat expansions cause 17 heritable human neurological disorders. In some diseases, somatic expansions occur in non-proliferating tissues such as brain where DNA replication is limited. This finding stimulated ...