Browsing by Author "Gabius, Hans-Joachim"
Now showing items 1-13 of 13
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Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins
Sabine André, Sabine; O'Sullivan, Shane; Koller, Christiane; Murphy, Paul V.; Gabius, Hans-Joachim (Royal Society of Chemistry, 2015-02-17)Emerging insights into the functional spectrum of tissue lectins leads to identification of new targets for the custom-made design of potent inhibitors, providing a challenge for synthetic chemistry. The affinity and ... -
Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)
Andre, Sabine; Wang, Guan-Nan; Gabius, Hans-Joachim; Murphy, Paul V. (Elsevier, 2014-05-07)Complementarity in lectin-glycan interactions in situ is assumed to involve spatial features in both the lectin and the glycan, giving a functional meaning to structural aspects of the lectin beyond its carbohydrate-binding ... -
Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity
O'Sullivan, Shane; Murphy, Paul V.; Gabius, Hans-Joachim; Sabine, Sabine (Elsevier, 2015-09-23)The emerging physiological significance of carbohydrate (glycan) protein (lectin) recognition engenders the interest to design synthetic inhibitors with a high level of selectivity among natural sugar receptors. Plant ... -
Influence of protein (human galectin-3) design on aspects of lectin activity
Caballero, Gabriel Garcia; Beckwith, Donella; Shilova, Nadezhda, V.; Gabba, Adele; Kutzner, Tanja J.; Ludwig, Anna-Kristin; Manning, Joachim C.; Kaltner, Herbert; Sinowatz, Fred; Cudic, Mare; Bovin, Nicolai, V.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2020-04-25)The concept of biomedical significance of the functional pairing between tissue lectins and their glycoconjugate counterreceptors has reached the mainstream of research on the flow of biological information. A major challenge ... -
Lectins: getting familiar with translators of the sugar code
André, Sabine; Kaltner, Herbert; Manning, Joachim; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2015-01-22)The view on the significance of the presence of glycans in glycoconjugates is undergoing a paradigmatic change. Initially mostly considered to be rather inert and passive, the concept of the sugar code identifies glycans ... -
Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context
André, Sabine; Kaltner, Herbert; Kayser, Klaus; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2015-11-09)Recognition of glycans by lectins leads to cell adhesion and growth regulation. The specificity and selectivity of this process are determined by carbohydrate structure (sequence and shape) and topology of its presentation. ... -
Multivalent carbohydrate-lectin interactions: how synthetic chemistry enables insights into nanometric recognition
Roy, René; Murphy, Paul; Gabius, Hans-Joachim (MDPI AG, 2016-05-13)Glycan recognition by sugar receptors (lectins) is intimately involved in many aspects of cell physiology. However, the factors explaining the exquisite selectivity of their functional pairing are not yet fully understood. ... -
Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles
André, Sabine; Velasco-Torrijos, Trinidad; Leyden, Rosaria; Gouin, Sebastien; Tosin, Manuela; Murphy, Paul V.; Gabius, Hans-Joachim (Royal Society of Chemistry (RSC), 2009-01-01)The conjugation of carbohydrates to synthetic scaffolds has the goal of preparing potent inhibitors of lectin binding. We herein report the synthesis of a panel of bivalent compounds (cyclophane and terephthalamide-derivatives) ... -
Probing sulfatide-tissue lectin recognition with functionalized glycodendrimersomes
Murphy, Paul V.; Romero, Antonio; Xiao, Qi; Ludwig, Anna-Kristin; Jogula, Srinivas; Shilova, Nadezhda V.; Singh, Tanuja; Gabba, Adele; Javed, Bilal; Zhang, Dapeng; Medrano, Francisco J.; Kaltner, Herbert; Kopitz, Jürgen; Bovin, Nicolai V.; Wu, Albert M.; Klein, Michael L.; Percec, Virgil; Gabius, Hans-Joachim (Cell Press, 2021-01-22)The small 3-O-sulfated galactose head group of sulfatides, an abundant glycosphingolipid class, poses the (sphinx-like) riddle on involvement of glycan bridging by tissue lectins (sugar code). First, synthesis of head group ... -
Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform
Kaltner, Herbert; Manning, Joachim C.; García Caballero, Gabriel; Di Salvo, Claudia; Gabba, Adele; Romero-Hernández, Laura L.; Knospe, Clemens; Wu, Dan; Daly, Harrison C.; O'Shea, Donal F.; Gabius, Hans-Joachim; Murphy, Paul V. (Royal Society of Chemistry, 2018-08-14)The increasing realization of the involvement of lectin-glycan recognition in (patho)physiological processes inspires envisioning therapeutic intervention by high-avidity/specificity blocking reagents. Synthetic glycoclusters ... -
Synthesis of bivalent lactosides based on terephthalamide,n,n′-diglucosylterephthalamide, and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins
Leyden, Rosaria; Velasco-Torrijos, Trinidad; André, Sabine; Gouin, Sebastien; Gabius, Hans-Joachim; Murphy, Paul V. (American Chemical Society (ACS), 2009-12-04)Glycan recognition by lectins initiates clinically relevant processes such as toxin binding or tumor spread. Thus, the development of potent inhibitors has a medical perspective. Toward this goal, we report the synthesis ... -
Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design
Roy, René; Cao, Yihong; Kaltner, Herbert; Kottari, Naresh; Shiao, Tze Chieh; Belkhadem, Karima; André, Sabine; Manning, Joachim C.; Murphy, Paul V.; Gabius, Hans-Joachim (Springer, 2016-06-24)A hallmark of endogenous lectins is their ability to select a few distinct glycoconjugates as counterreceptors for functional pairing from the natural abundance of cellular glycoproteins and glycolipids. As a consequence, ... -
The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity
Murphy, Paul; André, Sabine; Gabius, Hans-Joachim (MDPI AG, 2013-04-04)Coding of biological information is not confined to nucleic acids and proteins. Endowed with the highest level of structural versatility among biomolecules, the glycan chains of cellular glycoconjugates are well-suited to ...