Browsing by Subject "somatic mutations"
Now showing items 1-3 of 3
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A novel role for hsmg-1 in stress granule formation
(American Society for Microbiology, 2011-09-12)hSMG-1 is a member of the phosphoinositide 3 kinase-like kinase (PIKK) family with established roles in nonsense-mediated decay (NMD) of mRNA containing premature termination codons and in genotoxic stress responses to DNA ... -
Computational approaches to identify and explain sources of error in cancer somatic mutation data
(NUI Galway, 2024-04-18)Errors in the identification of somatic mutations in cancer samples can have critical implications in both research and clinical applications. Failure to detect potential variants of interest can lead to missed opportunities ... -
Targeted resequencing of the micrornaome and 3′utrome reveals functional germline dna variants with altered prevalence in epithelial ovarian cancer
(Springer Nature, 2014-06-09)Ovarian cancer is a major cause of cancer deaths, yet there have been few known genetic risk factors identified, the best known of which are disruptions in protein coding sequences (BRCA1 and 2). Recent findings indicate ...