Browsing by Subject "multiple-myeloma"

Now showing items 1-7 of 7

    • E-selectin ligands recognised by heca452 induce drug resistance in myeloma, which is overcome by the e-selectin antagonist, gmi-1271 

      Natoni, A; Smith, T A G; Keane, N; McEllistrim, C; Connolly, C; Jha, A; Andrulis, M; Ellert, E; Raab, M S; Glavey, S V; Kirkham-McCarthy, L; Kumar, S K; Locatelli-Hoops, S C; Oliva, I; Fogler, W E; Magnani, J L; O'Dwyer, M E (Springer Nature, 2017-04-25)
      Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme ...

    • Living with relapsed myeloma: symptoms and self-care strategies 

      Cormican, Orlaith; Dowling, Maura (Wiley-Blackwell, 2017-12-21)
      Aims and Objectives: To explore which symptoms relapsed myeloma patients experience and what self-care strategies are used. Methods: This was a qualitative study utilising focus group interviews (n=4) with relapsed myeloma ...

    • Plerixafor for pbsc mobilisation in myeloma patients with advanced renal failure: safety and efficacy data in a series of 21 patients from europe and the usa 

      Douglas, K W; Parker, A N; Hayden, P J; Rahemtulla, A; D'Addio, A; Lemoli, R M; Rao, K; Maris, M; Pagliuca, A; Uberti, J; Scheid, C; Noppeney, R; Cook, G; Bokhari, S W; Worel, N; Mikala, G; Masszi, T; Taylor, R; Treisman, J (Springer Nature, 2011-02-28)
      We describe 20 patients with myeloma and 1 with primary amyloidosis from 15 centres, all with advanced renal failure, most of whom had PBSC mobilised using plerixafor following previous failed mobilisation by conventional ...

    • Spinal metastatic disease: a review of the role of the multidisciplinary team 

      Curtin, Mark; Piggott, Robert P; Murphy, Evelyn P; Munigangaiah, Sudarshan; Baker, Joseph F; McCabe, John P; Devitt, Aiden (Wiley-Blackwell, 2017-05-01)
      Historically, a simple approach centered on palliation was applicable to the majority of patients with metastatic spinal disease. With advances in diagnosis and treatment, a more complicated algorithm has devolved requiring ...

    • Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones 

      Potter, Shirley M.; Dwyer, Róisín M.; Curran, Catherine E.; Hennessy, Emer; Harrington, Kate A.; Griffin, Damian G.; Kerin, Michael J. (Springer Nature, 2008-06-04)
      Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic ...

    • Targeting selectins and their ligands in cancer 

      Natoni, Alessandro; Macauley, Matthew S.; O’Dwyer, Michael E. (Frontiers Media SA, 2016-04-18)
      Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune ...

    • The impact of dialysis on the survival of patients with immunoglobulin light chain (al) amyloidosis undergoing autologous stem cell transplantation 

      Leung, Nelson; Kumar, Shaji K.; Glavey, Siobhan V.; Dispenzieri, Angela; Lacy, Martha Q.; Buadi, Francis K.; Hayman, Suzanne R.; Dingli, David; Kapoor, Prashant; Zeldenrust, Steven R.; Russell, Stephen J.; Lust, John A.; Hogan, William J.; Rajkumar, S. Vincent; Gastineau, Dennis A.; Kourelis, Taxiarchis V.; Lin, Yi; Gonsalves, Wilson I.; Go, Ronald S.; Gertz, Morie A. (Oxford University Press (OUP), 2015-11-30)
      Acute renal failure requiring dialysis is associated with high mortality during autologous stem cell transplantation (ASCT). This study examined the association between acute renal failure and mortality in immunoglobulin ...