Browsing by Subject "hydroxyurea"
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Cdc7-dependent and -independent phosphorylation of claspin in the induction of the dna replication checkpoint
(Informa UK Limited, 2013-05-15)Claspin is a critical mediator protein in the DNA replication checkpoint, responsible for ATR-dependent activation of the effector kinase Chk1. Cdc7, an essential kinase required for the initiation of DNA replication, can ...