Browsing by Subject "homologous recombination"
Now showing items 1-14 of 14
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Atr-atrip kinase complex triggers activation of the fanconi anemia dna repair pathway
(American Association for Cancer Research (AACR), 2012-01-18) -
Brca1 is required for maintenance of phospho-chk1 and g2/m arrest during dna cross-link repair in dt40 cells
(American Society for Microbiology, 2015-08-31)The Fanconi anemia DNA repair pathway is pivotal for the efficient repair of DNA interstrand cross-links. Here, we show that FA-defective (Fancc(-)) DT40 cells arrest in G(2) phase following cross-link damage and trigger ... -
Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins
(Rockefeller University Press, 2011-04-11)The principal microtubule-organizing center in animal cells, the centrosome, contains centrin, a small, conserved calcium-binding protein unique to eukaryotes. Several centrin isoforms exist and have been implicated in ... -
Determination of the number of RAD51 molecules in different human cell lines
(Taylor & Francis, 2019-11-15)Knowledge about precise numbers of specific molecules is necessary for understanding and verification of biological pathways. The RAD51 protein is central in the repair of DNA double-strand breaks (DSBs) by homologous ... -
Hypoxia enhances the radioresistance of mouse mesenchymal stromal cells
(Wiley-Blackwell, 2014-07-15)Mesenchymal stromal cells (MSCs) are radioresistant bone marrow progenitors that support hematopoiesis and its reconstitution following total body irradiation. MSCs reside in hypoxic niches within the bone marrow and tumor ... -
Interplay of dna damage and cell cycle signaling at the level of human replication protein a
(Elsevier BV, 2014-09-01) -
Mcph1/brit1 limits ionizing radiation-induced centrosome amplification
(Springer Nature, 2010-07-26)Microcephalin (MCPH1/BRIT1) is a potential tumour suppressor that localizes to the centrosome, forms ionizing radiation-induced nuclear foci (IRIF) and is involved in the DNA damage checkpoints that ensure genome stability. ... -
Parg is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(adp-ribose) upon prolonged replicative stress
(Oxford University Press (OUP), 2014-06-06)Poly(ADP-ribosyl)ation is involved in numerous biological processes including DNA repair, transcription and cell death. Cellular levels of poly(ADP-ribose) (PAR) are regulated by PAR polymerases (PARPs) and the degrading ... -
Parp-1 protects homologous recombination from interference by ku and ligase iv in vertebrate cells
(Wiley-Blackwell, 2006-02-23)Parp-1 and Parp-2 are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). Their involvement in double-strand break (DSB) repair mediated by homologous recombination (HR) or ... -
A role for USP9X in homologous recombination repair of DNA double strand breaks
(NUI Galway, 2020-02-11)In order to prevent the deleterious effects of a variety of genotoxic agents, cells have developed complex surveillance mechanisms and multiple DNA repair pathways that allow them to maintain genome integrity. The ... -
Rtel1 inhibits trinucleotide repeat expansions and fragility
(Elsevier BV, 2014-03-01)Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure. Here, we show that RTEL1 also blocks trinucleotide repeat expansions, ... -
The mrn complex: coordinating and mediating the response to broken chromosomes
(Wiley-Blackwell, 2003-09-01)The MRE11-RAD50-NBS1 (MRN) protein complex has been linked to many DNA metabolic events that involve DNA double-stranded breaks (DSBs). In vertebrate cells, all three components are encoded by essential genes, and hypomorphic ... -
The nse2/mms21 sumo ligase of the smc5/6 complex in the maintenance of genome stability
(Wiley-Blackwell, 2011-05-04) -
Trf1 is not required for proliferation or functional telomere maintenance in chicken dt40 cells
(American Society for Cell Biology (ASCB), 2009-03-25)The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a component of this complex ...