Browsing by Subject "Nucleolus"
Now showing items 1-6 of 6
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The genomic architecture of nucleolar organiser regions on the short arms of human acrocentric chromosomes
(2015-09-29)Nucleolar Organiser Regions (NORs) are comprised of ribosomal gene (rDNA) arrays and adjacent sequences. Nucleoli, the sites of ribosome biogenesis and key regulators of cellular growth and proliferation, form around NORs. ... -
Investigating nucleolar dynamics in karyotypically normal human cells by fluorescent protein tagging of genes encoding key nucleolar proteins
(NUI Galway, 2022-06-14)The nucleolus, the site of ribosome biogenesis, is the largest membrane-less structure or organelle in the eukaryotic nucleus. It forms around arrays of ribosomal gene (rDNA) repeats termed nucleolar organizer regions ... -
Nucleolar reorganisation promotes repair of rDNA double strand breaks by homologous recombination throughout the cell cycle.
(2013-12-16)The nucleolus is the largest functional domain within the nucleus and is the site of ribosome biogenesis. It has a distinct structure and houses ribosomal RNA gene (rDNA) transcription, pre-ribosomal RNA (pre-rRNA) processing, ... -
Organisation and function of the Nucleolar Organiser Regions in human chromosomes.
(2013-12-20)The short-arms of the five acrocentric human chromosomes contain sequences that direct the assembly and function of the nucleolus, one of the key functional domains of the nucleus and ribosomal biogenesis, yet they are ... -
A refined model of nucleolar formation derived from the analysis of UBF variants and the hierarchical silencing of human nucleolar organizer regions
(NUI Galway, 2017-03-23)The nucleolus, the largest sub-nuclear structure, forms around arrays of ribosomal RNA genes, termed nucleolar organizer regions (NORs). As the site of ribosome biogenesis, nucleolar function is intrinsically linked to ... -
Upstream Binding Factor, an Evolutionarily Conserved Protein that Organises Ribosomal Gene Chromatin
(2012-09-28)The nucleolus, the site of ribosome biogenesis, forms around arrays of ribosomal gene (rDNA) repeats termed nucleolar organiser regions (NORs). Transcriptionally active NORs appear as regions of under-condensed chromatin ...