Browsing by Author "Spillane, Charles"
Now showing items 1-20 of 47
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A polynucleotide repeat expansion causing temperature-sensitivity persists in wild irish accessions of arabidopsis thaliana
Tabib, Amanda; Vishwanathan, Sailaja; Seleznev, Andrei; McKeown, Peter C.; Downing, Tim; Dent, Craig; Sanchez-Bermejo, Eduardo; Colling, Luana; Spillane, Charles; Balasubramanian, Sureshkumar (Frontiers Media SA, 2016-08-31)Triplet repeat expansions underlie several human genetic diseases such as Huntington's disease and Friedreich's ataxia. Although such mutations are primarily known from humans, a triplet expansion associated genetic defect ... -
Analysing bovine sperm cells using flow cytometry
Waters, Irene (NUI Galway, 2024-04-10)The accurate assessment of bull fertility is extremely important to the beef and dairy industry. In recent years, flow cytometry has become the dominant approach in sperm evaluation and is increasingly being used for quality ... -
Assessing and exploiting functional diversity in germplasm pools to enhance abiotic stress adaptation and yield in cereals and food legumes
Dwivedi, Sangam L.; Scheben, Armin; Edwards, David; Spillane, Charles; Ortiz, Rodomiro (Frontiers Media SA, 2017-08-29)There is a need to accelerate crop improvement by introducing alleles conferring host plant resistance, abiotic stress adaptation, and high yield potential. Elite cultivars, landraces and wild relatives harbor useful genetic ... -
Biofortification for better nutrition: developing and delivering crops with more impact
Hummel, Marijke (NUI Galway, 2020-05-06)Background: Globally, around three billion people have inadequate diets and are often malnourished. Biofortification, a nutrition-sensitive approach that aims to increase the nutritional density of staple crops, has great ... -
Developing climate smart agriculture: Insights from Indonesia, Vietnam, Malawi and Ireland
Duffy, Colm (NUI Galway, 2019-11-18)The present and future challenges to agricultural development and food security are immense. The agricultural sector is a significant driver of climate change, but at the same time, is highly vulnerable to its impacts. ... -
Disaggregating polyploidy, parental genome dosage and hybridity contributions to heterosis in arabidopsis thaliana
Fort, Antoine; Ryder, Peter; McKeown, Peter C.; Wijnen, Cris; Aarts, Mark G.; Sulpice, Ronan; Spillane, Charles (Wiley-Blackwell, 2015-09-23)Heterosis is the phenomenon whereby hybrid offspring of genetically divergent parents display superior characteristics compared with their parents. Although hybridity and polyploidy can influence heterosis in hybrid plants, ... -
Dna sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in irish holstein-friesian cattle
Magee, David A; Sikora, Klaudia M; Berkowicz, Erik W; Berry, Donagh P; Howard, Dawn J; Mullen, Michael P; Evans, Ross D; Spillane, Charles; MacHugh, David E (Springer Nature, 2010-01-01)Background: Studies in mice and humans have shown that imprinted genes, whereby expression from one of the two parentally inherited alleles is attenuated or completely silenced, have a major effect on mammalian growth, ... -
Dna sequence polymorphisms within the bovine guanine nucleotide-binding protein gs subunit alpha (gsα)-encoding (gnas) genomic imprinting domain are associated with performance traits
Sikora, Klaudia M; Magee, David A; Berkowicz, Erik W; Berry, Donagh P; Howard, Dawn J; Mullen, Michael P; Evans, Ross D; MacHugh, David E; Spillane, Charles (Springer Nature, 2011-01-01)Background: Genes which are epigenetically regulated via genomic imprinting can be potential targets for artificial selection during animal breeding. Indeed, imprinted loci have been shown to underlie some important ... -
Draft genome sequence of pigeonpea (cajanus cajan), an orphan legume crop of resource-poor farmers
Varshney, Rajeev K; Chen, Wenbin; Li, Yupeng; Bharti, Arvind K; Saxena, Rachit K; Schlueter, Jessica A; Donoghue, Mark T A; Azam, Sarwar; Fan, Guangyi; Whaley, Adam M; Farmer, Andrew D; Sheridan, Jaime; Iwata, Aiko; Tuteja, Reetu; Penmetsa, R Varma; Wu, Wei; Upadhyaya, Hari D; Yang, Shiaw-Pyng; Shah, Trushar; Saxena, K B; Michael, Todd; McCombie, W Richard; Yang, Bicheng; Zhang, Gengyun; Yang, Huanming; Wang, Jun; Spillane, Charles; Cook, Douglas R; May, Gregory D; Xu, Xun; Jackson, Scott A (Springer Nature, 2011-11-06)Pigeonpea is an important legume food crop grown primarily by smallholder farmers in many semi-arid tropical regions of the world. We used the Illumina next-generation sequencing platform to generate 237.2 Gb of sequence, ... -
Effect of constituents from samaras of austroplenckia populnea (celastraceae) on human cancer cells
Caneschi, Carolina; Muniyappa, Mohan; Duarte, Lucienir; Silva, Grcia; Santos, Orlando; Spillane, Charles; Filho, Sidney (ScopeMed International Medical Journal Management and Indexing System, 2015-01-01)Background: Aiming the continuity of the studies of Austroplenckia populnea, Brazilian species of the Celastraceae family, in the present study, it was investigated the effect of crude extracts obtained with ethanol, ethyl ... -
Evolutionary origins of brassicaceae specific genes in arabidopsis thaliana
Donoghue, Mark TA; Keshavaiah, Channa; Swamidatta, Sandesh H; Spillane, Charles (Springer Nature, 2011-02-18)Background: All sequenced genomes contain a proportion of lineage-specific genes, which exhibit no sequence similarity to any genes outside the lineage. Despite their prevalence, the origins and functions of most lineage ... -
Functional characterization of orphan genes in Arabidopsis thaliana
Swamidatta, Sandesh (2015-01-28)All organisms are known to contain a unique set of genes called 'orphan genes', which do not share any similarity with genes or protein domains in other evolutionary lineages. Such orphan genes can impart unique traits to ... -
Functional effects of inter-genome interactions on seed development in Arabidopsis thaliana
Dupouy, Gilles A. (NUI Galway, 2022-01-14)Plant seed size determination is of high economic interest for modern food production worldwide as many crops are mainly consumed in the form of seeds, such as rice, wheat or corn. Parental conflict and genomic imprinting ... -
Functional genomics of microrna- directed regulation of tumorigenesis in human cancer cells
Selcuklu, Duygu (2011-09-30)In the past few decades, microRNAs emerged as key regulators of gene expression in many fundamental biological processes such as development and differentiation as well as diseases. There are thousands of microRNAs that ... -
Gamete fertility and ovule number variation in selfed reciprocal f1 hybrid triploid plants are heritable and display epigenetic parent-of-origin effects
Duszynska, Dorota; McKeown, Peter C.; Juenger, Thomas E.; Pietraszewska-Bogiel, Anna; Geelen, Danny; Spillane, Charles (Wiley-Blackwell, 2013-01-31)Polyploidy and hybridization play major roles in plant evolution and reproduction. To investigate the reproductive effects of polyploidy and hybridization in Arabidopsis thaliana, we analyzed fertility of reciprocal pairs ... -
Genetic analysis of carotenoid accumulation in tropical maize inbred lines using molecular tools and field tests for accelerating the biofortification of maize with provitamin A
Mekonnen, Girum (2015-05-13)Improving the nutritional content of staple crops through breeding (biofortification) is promoted as cheap and sustainable approach for alleviating vitamin A and other micronutrient deficiencies across the world. Maize is ... -
Genetic and biotechnological development of the pennate marine diatom Phaeodactylum tricornutum for high-value bioproducts and carbon bio-mitigation.
Kaur, Simrat (2014-04-25)Conflicting demands of food over fuel and the mushrooming need for feed and fibre are serious challenges for humankind at a time when we also need to address climate change challenges. Global demands for land based commodities ... -
Genetic basis for dosage sensitivity of seed size heterosis in Arabidopsis thaliana
Castillo Bravo, Rosa María (NUI Galway, 2021-09-08)Heterosis refers to the ability of the F1 offspring to display superior characteristics compared with their parents and despite being genetically studied since the early 1900s, many aspects of this phenomenon remain unclear. ... -
Genetic diversity, evolutionary history and epigenetic analysis of East African highland bananas
Kitavi, Mercy (2015-05-13)Genetic variation describes naturally occurring genetic differences among individuals of the same species and permits flexibility and survival of a population in the face of changing environmental circumstances, diseases ... -
Genetic loci controlling carotenoid biosynthesis in diverse tropical maize lines
Azmach, Girum; Menkir, Abebe; Spillane, Charles; Gedil, Melaku (Genetics Society of America, 2018-01-29)The discovery and use of genetic markers associated with carotenoid levels can help to exploit the genetic potential of maize for provitamin A accumulation more effectively. Provitamin A carotenoids are classes of carotenoids ...