Browsing by Author "Mohrin, Mary"

Now showing items 1-2 of 2

    • Hematopoietic stem cell quiescence promotes error-prone dna repair and mutagenesis 

      Mohrin, Mary; Bourke, Emer; Alexander, David; Warr, Matthew R.; Barry-Holson, Keegan; Le Beau, Michelle M.; Morrison, Ciaran G.; Passegué, Emmanuelle (Elsevier BV, 2010-08-01)
      Most adult stem cells, including hematopoietic stem cells (HSCs), are maintained in a quiescent or resting state in vivo. Quiescence is widely considered to be an essential protective mechanism for stem cells that minimizes ...

    • Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells 

      Flach, Johanna; Bakker, Sietske T.; Mohrin, Mary; Conroy, Pauline C.; Pietras, Eric M.; Reynaud, Damien; Alvarez, Silvia; Diolaiti, Morgan E.; Ugarte, Fernando; Forsberg, E. Camilla; Le Beau, Michelle M.; Stohr, Bradley A.; Méndez, Juan; Morrison, Ciaran G.; Passegué, Emmanuelle (Springer Nature, 2014-07-30)
      Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age(1,2). Paradoxically, although HSCs numerically expand with age, their functional activity declines over ...