Browsing by Author "Mohr, Andrea"
Now showing items 1-5 of 5
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Both human and mouse mesenchymal stem cells promote breast cancer metastasis
Albarenque, Stella Maris; Zwacka, Ralf Michael; Mohr, Andrea (Elsevier BV, 2011-09-01) -
Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Mohr, Andrea; Deedigan, Laura; Jencz, Sylwia; Mehrabadi, Yasamin; Houlden, Lily; Albarenque, Stella-Maris; Zwacka, Ralf M (Springer Nature, 2017-11-03)The mechanisms of how chemotherapeutic drugs lead to cell cycle checkpoint regulation and DNA damage repair are well understood, but how such signals are transmitted to the cellular apoptosis machinery is less clear. We ... -
Dr4 specific trail variants are more efficacious than wild-type trail in pancreatic cancer
Yu, Rui; Albarenque, Stella Maris; Cool, Robbert H; Quax, Wim J; Mohr, Andrea; Zwacka, Ralf M (Informa UK Limited, 2014-11-20)Current treatment modalities for pancreatic carcinoma afford only modest survival benefits. TRAIL, as a potent and specific inducer of apoptosis in cancer cells, would be a promising new treatment option. However, since ... -
Mesenchymal stem cells expressing trail lead to tumour growth inhibition in an experimental lung cancer model
Mohr, Andrea; Lyons, Mark; Deedigan, Laura; Harte, Tina; Shaw, Georgina; Howard, Linda; Barry, Frank; O'Brien, Tim; Zwacka, Ralf (Wiley-Blackwell, 2008-03-29)Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the ... -
Targeting of xiap combined with systemic mesenchymal stem cell-mediated delivery of strail ligand inhibits metastatic growth of pancreatic carcinoma cells
Mohr, Andrea; Albarenque, Stella Maris; Deedigan, Laura; Yu, Rui; Reidy, Mairead; Fulda, Simone; Zwacka, Ralf Michael (Wiley-Blackwell, 2010-11-01)Disseminating tumors are one of the gravest medical problems. Here, we combine the tumor-specific apoptosis-inducing activity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) with the ability of mesenchymal ...