Browsing by Author "Mohr, A."
Now showing items 1-4 of 4
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A non-apoptotic role for caspase-9 in muscle differentiation
Murray, T. V. A.; McMahon, J. M.; Howley, B. A.; Stanley, A.; Ritter, T.; Mohr, A.; Zwacka, R.; Fearnhead, H. O. (The Company of Biologists, 2008-10-28)Caspases, a family of cysteine proteases most often investigated for their roles in apoptosis, have also been demonstrated to have functions that are vital for the efficient execution of cell differentiation. One such role ... -
Constitutively activated nuclear factor- b, but not induced nf- b, leads to trail resistance by up-regulation of x-linked inhibitor of apoptosis protein in human cancer cells
Braeuer, S. J.; Buneker, C.; Mohr, A.; Zwacka, R. M. (American Association for Cancer Research (AACR), 2006-10-01)The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in most, but not all, cancer cells. The molecular factors regulating the sensitivity to TRAIL are still incompletely ... -
Manganese superoxide dismutase induces p53-dependent senescence in colorectal cancer cells
Behrend, L.; Mohr, A.; Dick, T.; Zwacka, R. M. (American Society for Microbiology, 2005-08-17)The mitochondrial enzyme manganese superoxide dismutase (MnSOD) is known to suppress cell growth in different tumor cell lines. However, the molecular mechanism of this growth-retarding effect is not fully understood. Here ... -
Trail-induced apoptosis is preferentially mediated via trail receptor 1 in pancreatic carcinoma cells and profoundly enhanced by xiap inhibitors
Stadel, D.; Mohr, A.; Ref, C.; MacFarlane, M.; Zhou, S.; Humphreys, R.; Bachem, M.; Cohen, G.; Moller, P.; Zwacka, R. M.; Debatin, K.-M.; Fulda, S. (American Association for Cancer Research (AACR), 2010-10-12)Purpose: We previously reported that small molecule X-linked inhibitor of apoptosis (XIAP) inhibitors synergize with soluble TRAIL to trigger apoptosis in pancreatic carcinoma cells. Because cancers may preferentially ...