Browsing by Author "McDowell, Cliona"

Now showing items 1-2 of 2

    • Phase ii clinical trial of first or second-line treatment with bortezomib in patients with malignant pleural mesothelioma 

      Fennell, Dean A.; McDowell, Cliona; Busacca, Sara; Webb, Glen; Moulton, Brian; Cakana, Andrew; O’Byrne, Kenneth J.; Meerbeeck, Jan V.; Donnellan, Paul; McCaffrey, John; Baas, Paul (Elsevier BV, 2012-09-01)
      Based on promising preclinical efficacy of bortezomib in mesothelioma, a single-arm phase II trial (Ireland Cooperative Oncology Research Group 05-10 study), with Simon's two-stage design, was undertaken to assess efficacy ...

    • Simvastatin in the acute respiratory distress syndrome 

      McAuley, Daniel F.; Laffey, John G.; O'Kane, Cecilia M.; Perkins, Gavin D.; Mullan, Brian; Trinder, T. John; Johnston, Paul; Hopkins, Philip A.; Johnston, Andrew J.; McDowell, Cliona; McNally, Christine; , (New England Journal of Medicine (NEJM/MMS), 2014-10-30)
      BACKGROUND Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of the acute respiratory distress syndrome (ARDS). This study tested the hypothesis that ...