Browsing by Author "Lynch, Kevin"
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Airflow reversal and alternating corkscrew vortices in foredune wake zones during perpendicular and oblique offshore winds
Jackson, Derek W.T.; Beyers, Meiring; Delgado-Fernandez, Irene; Baas, Andreas C.W.; Cooper, Andrew J.; Lynch, Kevin (Elsevier BV, 2013-04-01) -
Challenges for coastal management in Ireland. Case study: The Maharees, Castlegregory, County Kerry
Farrell, Eugene; Lynch, Kevin; Wilkes Orozco, Sinead; Castro Camba, Guillermo (NUI Galway, 2016)[No abstract available] -
The challenges of protecting rural coastal communities from climate change impacts. A Case Study: Maharees Conservation Association CLG
Farrell, Eugene; Finn, M.; Lynch, Kevin; Carr, L.; Wilkes Orozco, Sinead; Castro Camba, Guillermo (NUI Galway, 2018)[No abstract available] -
Comments on marine litter in oceans, seas and beaches: Characteristics and impacts
Anfuso, G.; Lynch, Kevin; Williams, A.T.; Perales, J.A.; Pereira da Silva, J.A.; Nogueira Mendes, R.; Maanan, M.; Pretti, C.; Pranzini, E.; Winter, C.; Verdejo, E.; Ferreira, M.; Veiga, J. (JSciMed Central, 2015-06-11)Abstract Marine litter is observed along shorelines, pelagic, benthic marine and lake systems all around the globe. On beaches, litter creates aesthetic and related economic problems because a clean beach is one of the ... -
Consideration of coastal risk in the Irish spatial planning process
Flannery, Wesley; Lynch, Kevin; Ó Cinnéide, Micheál (Elsevier, 2014-11-29)The vulnerability of coastal areas to associated hazards is increasing due to population growth, development pressure and climate change. It is incumbent on coastal governance regimes to address the vulnerability of coastal ... -
Consideration of coastal risk in the irish spatial planning process
Flannery, Wesley; Lynch, Kevin; Ó Cinnéide, Micheál (Elsevier BV, 2015-02-01) -
The fetch effect on aeolian sediment transport on a sandy beach: a case study from Magilligan Strand, Northern Ireland
Lynch, Kevin; Jackson, Derek W. T.; Cooper, J. Andrew G. (Wiley, 2016-04-22)Experiments were conducted on Magilligan Strand, Northern Ireland, to assess the influence of the fetch effect on aeolian sediment transport. During each experiment surface sediments were uniformly dry and unhindered by ... -
Field characterization of three-dimensional lee-side airflow patterns under offshore winds at a beach-dune system
Delgado-Fernandez, Irene; Jackson, Derek W. T.; Cooper, J. Andrew G.; Baas, Andreas C. W.; Beyers, J. H. Meiring; Lynch, Kevin (American Geophysical Union, 2013-05-22)Characterization of three-dimensional (3D) airflow remains elusive within a variety of environments and is particularly challenging over complex dune topography. Previous work examining airflow over and in the lee of dunes ... -
Field characterization of three-dimensional lee-side airflow patterns under offshore winds at a beach-dune system
Delgado-Fernandez, Irene; Jackson, Derek W. T.; Cooper, J. Andrew G.; Baas, Andreas C. W.; Beyers, J. H. Meiring; Lynch, Kevin (Wiley-Blackwell, 2013-05-22)Characterization of three-dimensional (3D) airflow remains elusive within a variety of environments and is particularly challenging over complex dune topography. Previous work examining airflow over and in the lee of dunes ... -
Foredune accretion under offshore winds
Cooper, J. Andrew G.; Jackson, Derek W. T.; Lynch, Kevin (Elsevier, 2007)Experiments carried out at Magilligan Strand on the north coast of Ireland suggest that topographic steering of offshore winds is an important facet of the aeolian sediment transport system at this location. A five-day ... -
Hijacking the 3Ss to ground reflective co-management of beach-dune environments
Lynch, Kevin (Elsevier, 2021-12-23)The global drive to provide the 3Ss (Sun, Sand and Sea) for the benefit of tourists has been a contributory factor in the parallel deterioration of beach-dune habitats on our coasts. In Europe, this has happened at a time ... -
Mechanistic insights into novel cellular therapy strategies for the treatment of corneal allograft rejection
Lynch, Kevin (NUI Galway, 2019-02-14)It has previously been demonstrated by our lab that tolerogenic dendritic cells (tDCs) prolong corneal allograft survival. This study revealed that tDCs had significantly higher levels of sialic acid on the cell surface ... -
Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation
Murphy, Nick; Lynch, Kevin; Lohan, Paul; Treacy, Oliver; Ritter, Thomas (Lippincott, Williams & Wilkins, 2016-12)PURPOSE OF REVIEW: This article reviews the literature on the therapeutic potential of mesenchymal stem cells (MSCs) to prolong corneal allograft survival. RECENT FINDINGS: To date, only small numbers studies have ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media SA, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ... -
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
O'Malley, Grace; Treacy, Oliver; Lynch, Kevin; Naicker, Serika D.; Leonard, Niamh A.; Lohan, Paul; Dunne, Philip D.; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (American Association for Cancer Research, 2018-11)Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ... -
Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice
Treacy, Oliver; Lynch, Kevin; Murphy, Nick; Chen, Xizhe; Donohoe, Ellen; Canning, Aoife; Lohan, Paul; Shaw, Georgina; Fahy, Gerry; Ryan, Aideen E.; Ritter, Thomas (BMC, 2021-04-06)Systemic administration of mesenchymal stromal cells (MSCs) has been efficacious in many inflammatory disease settings; however, little data are available on the potential immunomodulatory effects following local MSC ... -
TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo
Lynch, Kevin; Treacy, Oliver; Chen, Xizhe; Murphy, Nick; Lohan, Paul; Islam, Md Nahidul; Donohoe, Ellen; Griffin, Matthew D.; Watson, Luke; McLoughlin, Steven; O'Malley, Grace; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2020-05-29)Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ... -
Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation
Lohan, Paul; Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Bingling, Chen; Ryan, Aideen E.; Griffin, Matthew D.; Ritter, Thomas (Frontiers Media, 2018-11-20)High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ... -
TNF-a/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung.
Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Lohan, Paul; Howard, Linda; Fahy, Gerry; Griffin, Matthew D.; Ryan, Aideen E.; Ritter, Thomas (Federation of American Society of Experimental Biology (FASEB), 2019-05-20)Mesenchymal stromal cells (MSCs) have shown promise as a therapy for immune-mediated disorders, including transplant rejection. Our group previously demonstrated the efficacy of pretransplant, systemic administration of ...