Browsing by Author "Howard, Linda"
Now showing items 1-13 of 13
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361. lentiviral vector transduction efficiency and biosafety profile of adult mesenchymal stem cells
McGrath, Barry M.; O'Shea, Ciara; Howard, Linda; Murphy, Mary; Barry, Frank; O'Brien, Timothy; Strappe, Padraig M. (Elsevier BV, 2006-01-01) -
Allogeneic murine mesenchymal stem cells: migration to inflamed joints in vivo and amelioration of collagen induced arthritis when transduced to express ctla4ig
Sullivan, Catherine; Barry, Frank; Ritter, Thomas; O'Flatharta, Cathal; Howard, Linda; Shaw, Georgina; Anegon, Ignacio; Murphy, Mary (Mary Ann Liebert Inc, 2013-12-15)Despite the immunosuppressive, homing, and regenerative capabilities of mesenchymal stem cells (MSCs), their ability to migrate to arthritic joints and influence the course of arthritis in vivo remains poorly understood. ... -
Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan (Elsevier, 2018-09-26)Background: The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an altemative model extremely attractive. The use ofex vivo slice cultures is an ... -
Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction–based detection of human DNA in murine organs
Creane, Michael; Howard, Linda; O'Brien, Timothy; Coleman, Cynthia M. (Elsevier, 2017-01-12)Background. Determining the distributive fate and retention of a cell therapy product after administration is an essential part of characterizing it's biosafety profile. Therefore, regulatory guidelines stipulate that ... -
Cell viability in three ex vivo rat models of spinal cord injury
Patar, Azim; Dockery, Peter; Howard, Linda; McMahon, Siobhan S. (Wiley, 2018-11-11)Spinal cord injury (SCI) is a devastating disorder that has a poor prognosis of recovery. Animal models of SCI are useful to understand the pathophysiology of SCI and the potential use of therapeutic strategies for human ... -
Circulating MicroRNAs in cancer
O’Brien, Killian P.; Ramphul, Eimear; Howard, Linda; Gallagher, William M.; Malone, Carmel; Kerin, Michael J.; Dwyer, Róisín M. (Humana Press, 2016-11-09)It is believed that microRNAs have potential as circulating biomarkers of disease, however successful clinical implementation remains a challenge. This chapter highlights broad variations in approaches to microRNA analysis ... -
Ex Vivo slice culture model of rat spinal cord injury as a platform for testing proposed treatment strategies
Ab Patar, Mohd Nor Azim (NUI Galway, 2018-04-13)There are several detrimental events that occur in the aftermath of a spinal cord injury (SCI); these include glial scar formation, accumulation of axon growth inhibitors and immune mediators. These events present challenges ... -
Gene-eluting stents: adenovirus-mediated delivery of enos to the blood vessel wall accelerates re-endothelialization and inhibits restenosis
Sharif, Faisal; Hynes, Sean O; Cooney, Ronan; Howard, Linda; McMahon, Jill; Daly, Kieran; Crowley, James; Barry, Frank; O'Brien, Timothy (Elsevier BV, 2008-10-01)Drug-eluting stents for coronary artery disease results in inhibition of smooth muscle cell (SMC) and endothelial cells which may increase the risk of stent thrombosis. In this study, we attempted to enhance re-endothelialization ... -
Growth differentiation factor-5 enhances in vitro mesenchymal stromal cell chondrogenesis and hypertrophy
Coleman, Cynthia M.; Vaughan, Erin E.; Browe, David C.; Mooney, Emma; Howard, Linda; Barry, Frank (Mary Ann Liebert Inc, 2013-07-01)The regenerative potential for adult bone marrow-derived mesenchymal stromal cells (MSCs) has been extensively investigated in the setting of arthritic disease and focal cartilage defects. In vitro chondrogenic differentiation ... -
Inefficiency in macromolecular transport of SCS‐based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells
Sanz-Nogués, Clara; Horan, Jason; Thompson, Kerry; Howard, Linda; Ryan, Gerard; Kassem, Moustapha; O'Brien, Timothy (Wiley, 2015-05-01)Microcapsules made of sodium cellulose sulphate (SCS) and poly-diallyl-dimethyl-ammonium chloride (pDADMAC) have been employed to encapsulate a wide range of established cell lines for several applications. However, little ... -
Kinetics of thermally induced heat shock protein 27 and 70 expression by bone marrow-derived mesenchymal stem cells
Moloney, Teresa C.; Hoban, Deirdre B.; Barry, Frank P.; Howard, Linda; Dowd, Eilís (Wiley-Blackwell, 2012-05-08)Although bone marrow-derived mesenchymal stem cells (MSCs) are an attractive cell therapy candidate, their potential is limited by poor survival following transplantation. Over-expression of anti-apoptotic heat shock ... -
Mesenchymal stem cells expressing trail lead to tumour growth inhibition in an experimental lung cancer model
Mohr, Andrea; Lyons, Mark; Deedigan, Laura; Harte, Tina; Shaw, Georgina; Howard, Linda; Barry, Frank; O'Brien, Tim; Zwacka, Ralf (Wiley-Blackwell, 2008-03-29)Lung cancer is a major public health problem in the western world, and gene therapy strategies to tackle this disease systemically are often impaired by inefficient delivery of the vector to the tumour tissue. Some of the ... -
TNF-a/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung.
Murphy, Nick; Treacy, Oliver; Lynch, Kevin; Morcos, Maurice; Lohan, Paul; Howard, Linda; Fahy, Gerry; Griffin, Matthew D.; Ryan, Aideen E.; Ritter, Thomas (Federation of American Society of Experimental Biology (FASEB), 2019-05-20)Mesenchymal stromal cells (MSCs) have shown promise as a therapy for immune-mediated disorders, including transplant rejection. Our group previously demonstrated the efficacy of pretransplant, systemic administration of ...