Browsing by Author "Gorman, Adrienne M."
Now showing items 1-20 of 20
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Antioxidant-mediated inhibition of the heat shock response leads to apoptosis
Gorman, Adrienne M.; Heavey, Barry; Creagh, Emma; Cotter, Thomas G; Samali, Afshin (Wiley-Blackwell, 1999-02-19) -
Considerations and recent advances in neuroscience
Gorman, Adrienne M.; Doyle, Karen M. (Portland Press Ltd., 2009-02-01)Neuroscience is a rapidly developing area of science which has benefitted from the blurring of interdisciplinary boundaries. This was apparent in the range of papers presented at this year's Neuroscience Ireland Conference, ... -
Disruption of microrna biogenesis confers resistance to er stress-induced cell death upstream of the mitochondrion
Cawley, Karen; Logue, Susan E.; Gorman, Adrienne M.; Zeng, Qingping; Patterson, John; Gupta, Sanjeev; Samali, Afshin (Public Library of Science (PLoS), 2013-08-19)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine
Kavanagh, Edel T.; Loughlin, John P.; Herbert, Kate Reed; Dockery, Peter; Samali, Afshin; Doyle, Karen M.; Gorman, Adrienne M. (Elsevier BV, 2006-12-01) -
Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity
Carleton, Laura A.; Chakravarthy, Reka; van der Sloot, Almer M.; Mnich, Katarzyna; Serrano, Luis; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2017-11-03)Nerve growth factor (NGF) is the prototypic member of the neurotrophin family and binds two receptors, TrkA and the 75 kDa neurotrophin receptor (p75NTR), through which diverse and sometimes opposing effects are mediated. ... -
Hspb1 facilitates erk-mediated phosphorylation and degradation of bim to attenuate endoplasmic reticulum stress-induced apoptosis
Kennedy, Donna; Mnich, Katarzyna; Oommen, Deepu; Chakravarthy, Reka; Almeida-Souza, Leonardo; Krols, Michiel; Saveljeva, Svetlana; Doyle, Karen M.; Gupta, Sanjeev; Timmerman, Vincent; Janssens, Sophie; Gorman, Adrienne M.; Samali, Afshin (Springer Nature, 2017-08-31)BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells ... -
Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells
Mnich, Katarzyna; Finn, David P.; Dowd, Eilis; Gorman, Adrienne M. (2010)6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease. Here, we investigated the effects of the endogenous cannabinoid, ... -
The integrated stress response
Pakos-Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M. (EMBO Press, 2016-09-14)In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ... -
Loss of cannabinoid cb1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of parkinson's disease in the rat
Walsh, Sinéad; Mnich, Katarzyna; Mackie, Ken; Gorman, Adrienne M.; Finn, David P.; Dowd, Eilís (Elsevier BV, 2010-04-01) -
Mediators of endoplasmic reticulum stress-induced apoptosis
Szegezdi, Eva; Logue, Susan E; Gorman, Adrienne M.; Samali, Afshin (Wiley-Blackwell, 2006-09-01)The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ... -
Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells
Chakravarthy, Reka; Mnich, Katarzyna; Gorman, Adrienne M. (Elsevier, 2016)Triple negative breast cancer [TNBC] cells are reported to secrete the neurotrophin nerve growth factor [NGF] and express its receptors, p75 neurotrophin receptor [p75(NTR)] and TrkA, leading to NGF-activated pro-survival ... -
Nerve Growth Factor in Cancer Cell Death and Survival
Molloy, Niamh H.; Read, Danielle E.; Gorman, Adrienne M. (MDPI, 2011-02)One of the major challenges for cancer therapeutics is the resistance of many tumor cells to induction of cell death due to pro-survival signaling in the cancer cells. Here we review the growing literature which shows that ... -
Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Gorman, Adrienne M. (Wiley-Blackwell, 2008-07-10)Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell ... -
RIP2 enhances cell survival by activation of NF-ĸB in triple negative breast cancer cells
Jaafar, Rola; Mnich, Katarzyna; Dolan, Sarah; Hillis, Jennifer; Almanza, Aitor; Logue, Susan E.; Samali, Afshin; Gorman, Adrienne M. (Elsevier, 2018-02-06)Receptor-interacting protein 2 (RIP2) is an essential mediator of inflammation and innate immunity, but little is known about its role outside the immune system. Recently, RIP2 has been linked to chemoresistance of triple ... -
Role of mitochondria in neuronal apoptosis
Gorman, Adrienne M.; Ceccatelli, Sandra; Orrenius, Sten (Karger Publishers, 2000-12)Apoptosis is a controlled form of cell death that participates in the demise of neuronal cells during development, neurodegenerative disorders and exposure to neurotoxic agents. In recent years, the mitochondria have emerged ... -
Stress management at the ER: regulators of ER stress-induced apoptosis.
Gorman, Adrienne M.; Healy, Sandra J.M.; Jäger, Richard; Samali, Afshin (Elsevier, 2012-02-17)The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are ... -
The integrated stress response
Pakos‐Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M. (EMBO, 2016-09-14)In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation ... -
The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress
Jäger, Richard; Bertrand, Mathieu J.M.; Gorman, Adrienne M.; Vandenabeele, Peter; Samali, Afshin (Wiley-Blackwell, 2012-02-29)One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein response (UPR). ER stress and the UPR are both implicated in numerous human diseases and pathologies. In ... -
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
Moreira da Silva Santos, Andreia; Gorman, Adrienne M.; Kelly, John P.; Doyle, Karen M. (Elsevier, 2019-11-03)Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ... -
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders
Doyle, Karen M.; Kennedy, Donna; Gorman, Adrienne M.; Gupta, Sanjeev; Healy, Sandra J. M.; Samali, Afshin (Wiley-Blackwell, 2011-09-26)The stimuli for neuronal cell death in neurodegenerative disorders are multi-factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, ...