Browsing by Author "Gorman, A M"
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Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner
Mnich, K; Carleton, L A; Kavanagh, E T; Doyle, Karen M.; Samali, A; Gorman, A M (Springer Nature, 2014-05-01)Nerve growth factor (NGF) is well characterised as an important pro-survival factor in neuronal cells that can inhibit apoptotic cell death upstream of mitochondrial outer membrane permeabilisation. Here we addressed the ... -
The novel toluidine sulphonamide el102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents mdr1 resistance
Toner, A P; McLaughlin, F; Giles, F J; Sullivan, F J; O'Connell, E; Carleton, L A; Breen, L; Dunne, G; Gorman, A M; Lewis, J D; Glynn, S A (Springer Nature, 2013-09-19)Background: Taxanes are routinely used for the treatment of prostate cancer, however the majority of patients eventually develop resistance. We investigated the potential efficacy of EL102, a novel toluidine sulphonamide, ...