Browsing by Author "Coyle, Robert"
Now showing items 1-4 of 4
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Barton esters for initiator-free radical cyclisation with heteroaromatic substitution and anti-cancer evaluation of benzo[e][1,2,4]triazin-7-ones
Coyle, Robert (2014-07-03)Chapter 1 provides a general introduction to Chapters 2-5. Homolytic aromatic substitution routes to alicyclic ring-fused azoles and diazoles is reviewed. A review of recent literature using the COMPARE program of the ... -
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition
Sweeney, Martin; Coyle, Robert; Kavanagh, Paul; Berezin, Andrey A.; Lo Re, Daniele; Zissimou, Georgia A.; Koutentis, Panayiotis A.; Carty, Michael P.; Aldabbagh, Fawaz (Elsevier, 2016-05-30)The thioredoxin (Trx)-thioredoxin reductase (TrxR) system plays a key role in maintaining the cellular redox balance with Trx being over-expressed in a number of cancers. Inhibition of TrxR is an important strategy for ... -
Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition
Sweeney, Martin; Coyle, Robert; Kavanagh, Paul; Berezin, Andrey A.; Lo Re, Daniele; Zissimou, Georgia A.; Koutentis, Panayiotis A.; Carty, Michael P.; Aldabbagh, Fawaz (Elsevier BV, 2016-08-01) -
Tandem reactions via Barton Esters with intermolecular addition and vinyl radical substitution onto indole
Coyle, Robert; McArdle, Patrick; Aldabbagh, Fawaz (American Chemical Society, 2014-05-16)A one-pot initiator-free Barton ester decomposition with tandem radical addition onto alkyl propiolates or phenylacetylene with aromatic substitution of the resultant vinyl radical allows convenient access to new 9-substituted ...