Browsing by Subject "breast-cancer"
Now showing items 1-20 of 38
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A circulating microrna signature as a biomarker for prostate cancer in a high risk group
(MDPI AG, 2015-07-07)Introduction: Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs ... -
A model to predict psychological- and health-related adjustment in men with prostate cancer: the role of post traumatic growth, physical post traumatic growth, resilience and mindfulness
(Frontiers Media SA, 2018-02-15)Background: Post traumatic growth (PTG) can be defined as positive change following a traumatic event. The current conceptualization of PTG encompasses five main dimensions, however, there is no dimension which accounts ... -
A review of expression profiling of circulating micrornas in men with prostate cancer
(Wiley-Blackwell, 2012-05-22)MicroRNAs (miRNAs) are small non-coding RNAs that are involved in gene regulation and expression. These molecules have been implicated in the pathogenesis of several malignancies. MiRNAs have the potential to be both a ... -
Advances in precision medicine: tailoring individualized therapies
(MDPI AG, 2017-10-25)The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately ... -
Brca1 is required for maintenance of phospho-chk1 and g2/m arrest during dna cross-link repair in dt40 cells
(American Society for Microbiology, 2015-08-31)The Fanconi anemia DNA repair pathway is pivotal for the efficient repair of DNA interstrand cross-links. Here, we show that FA-defective (Fancc(-)) DT40 cells arrest in G(2) phase following cross-link damage and trigger ... -
Cancer-related fatigue in post-treatment cancer survivors: application of the common sense model of illness representations
(Springer Nature, 2016-11-25)Background: Cancer-related fatigue (CrF) is a common and disruptive symptom that may be experienced during and after cancer. Research into the subjective experience of fatigue in this group is required. The common sense ... -
Circulating nucleosomes and nucleosome modifications as biomarkers in cancer
(MDPI AG, 2017-01-08)Traditionally the stratification of many cancers involves combining tumour and clinicopathological features (e.g., patient age; tumour size, grade, receptor status and location) to inform treatment options and predict ... -
Cross platform standardisation of an experimental pipeline for use in the identification of dysregulated human circulating mirnas
(Public Library of Science (PLoS), 2015-09-10)Introduction Micro RNAs (miRNAs) are a class of highly conserved small non-coding RNAs that play an important part in the post-transcriptional regulation of gene expression. A substantial number of miRNAs have been proposed ... -
Development and progress of ireland's biobank network: ethical, legal, and social implications (elsi), standardized documentation, sample and data release, and international perspective
(Mary Ann Liebert Inc, 2013-02-01)Biobank Ireland Trust (BIT) was established in 2004 to promote and develop an Irish biobank network to benefit patients, researchers, industry, and the economy. The network commenced in 2008 with two hospital biobanks and ... -
Disruption of microrna biogenesis confers resistance to er stress-induced cell death upstream of the mitochondrion
(Public Library of Science (PLoS), 2013-08-19)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Elevated herv-k mrna expression in pbmc is associated with a prostate cancer diagnosis particularly in older men and smokers
(Oxford University Press (OUP), 2014-05-23)Aberrant expression of subgroup k human endogenous retroviruses (HERV-K) has been observed in prostate cancer. This subgroup is unique because it encodes sequences in the human genome containing open reading frames for ... -
Estrogen plus estrogen receptor antagonists alter mineral production by osteoblasts in vitro
(Thieme Publishing Group, 2011-11-28)In early postmenopausal women, estrogen withdrawal is associated with increased bone turnover leading to bone loss and increased risk of fracture. Recent studies have suggested that the remaining bone tissue is significantly ... -
Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the lung safe prospective cohort study
(Elsevier BV, 2017-08-01)Background Little information is available about the geo-economic variations in demographics, management, and outcomes of patients with acute respiratory distress syndrome (ARDS). We aimed to characterise the effect of ... -
Identification of endogenous control genes for normalisation of real-time quantitative pcr data in colorectal cancer
(Springer Nature, 2010-01-01)Background: Gene expression analysis has many applications in cancer diagnosis, prognosis and therapeutic care. Relative quantification is the most widely adopted approach whereby quantification of gene expression is ... -
Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer
(Springer Nature, 2014-01-01)Background: The cell and tissue structural properties assessed with a conventional bright-field light microscope play a key role in cancer diagnosis, but they sometimes have limited accuracy in detecting early-stage cancers ... -
Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer
(Royal Society of Chemistry (RSC), 2010-01-01)This critical review evaluates progress toward viable point-of-care protein biomarker measurements for cancer detection and diagnostics. The ability to measure panels of specific, selective cancer biomarker proteins in ... -
Measuring a new facet of post traumatic growth: development of a scale of physical post traumatic growth in men with prostate cancer
(Public Library of Science (PLoS), 2018-04-27)Purpose This study developed a measure of physical post traumatic growth (physical post traumatic growth inventory; P-PTGI) in men with prostate cancer. Methods A pool of items was created from themes identified in a ... -
Mesenchymal stem cells: key players in cancer progression
(Springer Nature, 2017-02-01)Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, ... -
Mesenchymal stromal cells (mscs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?
(Impact Journals, LLC, 2016-08-17)The tumour microenvironment (TME) is an important factor in determining the growth and metastasis of colorectal cancer, and can aid tumours by both establishing an immunosuppressive milieu, allowing the tumour avoid immune ... -
Metabolic alterations and targeted therapies in prostate cancer
(Wiley-Blackwell, 2010-11-16)