Browsing by Subject "breast-cancer"

Now showing items 21-38 of 38

    • Microfluidic array for simultaneous detection of dna oxidation and dna-adduct damage 

      Song, Boya; Shen, Min; Jiang, Di; Malla, Spundana; Mosa, Islam M.; Choudhary, Dharamainder; Rusling, James F. (Royal Society of Chemistry (RSC), 2016-01-01)
      Exposure to chemical pollutants and pharmaceuticals may cause health issues caused by metabolite-related toxicity. This paper reports a new microfluidic electrochemical sensor array with the ability to simultaneously detect ...

    • Micrornas in colorectal cancer: function, dysregulation and potential as novel biomarkers 

      Nugent, M.; Miller, N.; Kerin, M.J. (Elsevier BV, 2011-08-01)

    • Migrastatin analogues inhibit canine mammary cancer cell migration and invasion 

      Majchrzak, Kinga; Lo Re, Daniele; Gajewska, Małgorzata; Bulkowska, Małgorzata; Homa, Agata; Pawłowski, Karol; Motyl, Tomasz; Murphy, Paul V.; Król, Magdalena (Public Library of Science (PLoS), 2013-10-08)
      Background: Cancer spread to other organs is the main cause of death of oncological patients. Migration of cancer cells from a primary tumour is the crucial step in the complex process of metastasis, therefore blocking ...

    • Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity 

      Ridnour, L. A.; Cheng, R. Y. S.; Switzer, C. H.; Heinecke, J. L.; Ambs, S.; Glynn, S.; Young, H. A.; Trinchieri, G.; Wink, D. A. (American Association for Cancer Research (AACR), 2012-12-27)

    • Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach 

      McCarthy, S. D.; Waters, S. M.; Kenny, D. A.; Diskin, M. G.; Fitzpatrick, R.; Patton, J.; Wathes, D. C.; Morris, D. G. (American Physiological Society, 2010-08-17)
      McCarthy SD, Waters SM, Kenny DA, Diskin MG, Fitzpatrick R, Patton J, Wathes DC, Morris DG. Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a ...

    • Objective assessment of image quality vi: imaging in radiation therapy 

      Barrett, Harrison H; Kupinski, Matthew A; Müeller, Stefan; Halpern, Howard J; Morris, John C; Dwyer, Róisín M. (IOP Publishing, 2013-11-07)
      Earlier work on objective assessment of image quality (OAIQ) focused largely on estimation or classification tasks in which the desired outcome of imaging is accurate diagnosis. This paper develops a general framework for ...

    • Open-ended coaxial probe technique for dielectric measurement of biological tissues: challenges and common practices 

      La Gioia, Alessandra; Porter, Emily; Merunka, Ilja; Shahzad, Atif; Salahuddin, Saqib; Jones, Marggie; O’Halloran, Martin (MDPI AG, 2018-06-05)
      Electromagnetic (EM) medical technologies are rapidly expanding worldwide for both diagnostics and therapeutics. As these technologies are low-cost and minimally invasive, they have been the focus of significant research ...

    • Palb2,chek2andatmrare variants and cancer risk: data from cogs 

      Southey, Melissa C; Goldgar, David E; Winqvist, Robert; Pylkäs, Katri; Couch, Fergus; Tischkowitz, Marc; Foulkes, William D; Dennis, Joe; Michailidou, Kyriaki; van Rensburg, Elizabeth J; Heikkinen, Tuomas; Nevanlinna, Heli; Hopper, John L; Dörk, Thilo; Claes, Kathleen BM; Reis-Filho, Jorge; Teo, Zhi Ling; Radice, Paolo; Catucci, Irene; Peterlongo, Paolo; Tsimiklis, Helen; Odefrey, Fabrice A; Dowty, James G; Schmidt, Marjanka K; Broeks, Annegien; Hogervorst, Frans B; Verhoef, Senno; Carpenter, Jane; Clarke, Christine; Scott, Rodney J; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Peto, Julian; dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Bolla, Manjeet K; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federik; Burwinkel, Barbara; Yang, Rongxi; Guénel, Pascal; Truong, Thérèse; Menegaux, Florence; Sanchez, Marie; Bojesen, Stig; Nielsen, Sune F; Flyger, Henrik; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Anton-Culver, Hoda; Neuhausen, Susan; Ziogas, Argyrios; Clarke, Christina A; Brenner, Hermann; Arndt, Volker; Stegmaier, Christa; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia V; Antonenkova, Natalia N; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Spurdle, Amanda B; Investigators, kConFab; Wauters, Els; Smeets, Dominiek; Beuselinck, Benoit; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Olson, Janet E; Vachon, Celine; Pankratz, Vernon S; McLean, Catriona; Haiman, Christopher A; Henderson, Brian E; Schumacher, Fredrick; Le Marchand, Loic; Kristensen, Vessela; Alnæs, Grethe Grenaker; Zheng, Wei; Hunter, David J; Lindstrom, Sara; Hankinson, Susan E; Kraft, Peter; Andrulis, Irene; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Jukkola-Vuorinen, Arja; Grip, Mervi; Kauppila, Saila; Devilee, Peter; Tollenaar, Robert A E M; Seynaeve, Caroline; Hollestelle, Antoinette; Garcia-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Eccles, Diana M; Rafiq, Sajjad; Tapper, William J; Gerty, Sue M; Hooning, Maartje J; Martens, John W M; Collée, J Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Cox, Angela; Reed, Malcolm W R; Luccarini, Craig; Baynes, Caroline; Dunning, Alison M; Hamann, Ute; Torres, Diana; Ulmer, Hans Ulrich; Rüdiger, Thomas; Jakubowska, Anna; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Slager, Susan; Toland, Amanda E; Ambrosone, Christine B; Yannoukakos, Drakoulis; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Jones, Michael; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Álvarez, Nuria; Herrero, Daniel; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Simard, Jacques; Dumont, Martine; Soucy, Penny; Eeles, Rosalind; Muir, Kenneth; Wiklund, Fredrik; Gronberg, Henrik; Schleutker, Johanna; Nordestgaard, Børge G; Weischer, Maren; Travis, Ruth C; Neal, David; Donovan, Jenny L; Hamdy, Freddie C; Khaw, Kay-Tee; Stanford, Janet L; Blot, William J; Thibodeau, Stephen; Schaid, Daniel J; Kelley, Joseph L; Maier, Christiane; Kibel, Adam S; Cybulski, Cezary; Cannon-Albright, Lisa; Butterbach, Katja; Park, Jong; Kaneva, Radka; Batra, Jyotsna; Teixeira, Manuel R; Kote-Jarai, Zsofia; Olama, Ali Amin Al; Benlloch, Sara; Renner, Stefan P; Hartmann, Arndt; Hein, Alexander; Ruebner, Matthias; Lambrechts, Diether; Van Nieuwenhuysen, Els; Vergote, Ignace; Lambretchs, Sandrina; Doherty, Jennifer A; Rossing, Mary Anne; Nickels, Stefan; Eilber, Ursula; Wang-Gohrke, Shan; Odunsi, Kunle; Sucheston-Campbell, Lara E; Friel, Grace; Lurie, Galina; Killeen, Jeffrey L; Wilkens, Lynne R; Goodman, Marc T; Runnebaum, Ingo; Hillemanns, Peter A; Pelttari, Liisa M; Butzow, Ralf; Modugno, Francesmary; Edwards, Robert P; Ness, Roberta B; Moysich, Kirsten B; du Bois, Andreas; Heitz, Florian; Harter, Philipp; Kommoss, Stefan; Karlan, Beth Y; Walsh, Christine; Lester, Jenny; Jensen, Allan; Kjaer, Susanne Krüger; Høgdall, Estrid; Peissel, Bernard; Bonanni, Bernardo; Bernard, Loris; Goode, Ellen L; Fridley, Brooke L; Vierkant, Robert A; Cunningham, Julie M; Larson, Melissa C; Fogarty, Zachary C; Kalli, Kimberly R; Liang, Dong; Lu, Karen H; Hildebrandt, Michelle A T; Wu, Xifeng; Levine, Douglas A; Dao, Fanny; Bisogna, Maria; Berchuck, Andrew; Iversen, Edwin S; Marks, Jeffrey R; Akushevich, Lucy; Cramer, Daniel W; Schildkraut, Joellen; Terry, Kathryn L; Poole, Elizabeth M; Stampfer, Meir; Tworoger, Shelley S; Bandera, Elisa V; Orlow, Irene; Olson, Sara H; Bjorge, Line; Salvesen, Helga B; van Altena, Anne M; Aben, Katja K H; Kiemeney, Lambertus A; Massuger, Leon F A G; Pejovic, Tanja; Bean, Yukie; Brooks-Wilson, Angela; Kelemen, Linda E; Cook, Linda S; Le, Nhu D; Górski, Bohdan; Gronwald, Jacek; Menkiszak, Janusz; Høgdall, Claus K; Lundvall, Lene; Nedergaard, Lotte; Engelholm, Svend Aage; Dicks, Ed; Tyrer, Jonathan; Campbell, Ian; McNeish, Iain; Paul, James; Siddiqui, Nadeem; Glasspool, Rosalind; Whittemore, Alice S; Rothstein, Joseph H; McGuire, Valerie; Sieh, Weiva; Cai, Hui; Shu, Xiao-Ou; Teten, Rachel T; Sutphen, Rebecca; McLaughlin, John R; Narod, Steven A; Phelan, Catherine M; Monteiro, Alvaro N; Fenstermacher, David; Lin, Hui-Yi; Permuth, Jennifer B; Sellers, Thomas A; Chen, Y Ann; Tsai, Ya-Yu; Chen, Zhihua; Gentry-Maharaj, Aleksandra; Gayther, Simon A; Ramus, Susan J; Menon, Usha; Wu, Anna H; Pearce, Celeste L; Van Den Berg, David; Pike, Malcolm C; Dansonka-Mieszkowska, Agnieszka; Plisiecka-Halasa, Joanna; Moes-Sosnowska, Joanna; Kupryjanczyk, Jolanta; Pharoah, Paul DP; Song, Honglin; Winship, Ingrid; Chenevix-Trench, Georgia; Giles, Graham G; Tavtigian, Sean V; Easton, Doug F; Milne, Roger L; , (BMJ, 2016-09-05)
      Background The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...

    • Prognostic factors in advanced cancer patients: evidence-based clinical recommendations—a study by the steering committee of the european association for palliative care 

      Maltoni, Marco; Caraceni, Augusto; Brunelli, Cinzia; Broeckaert, Bert; Christakis, Nicholas; Eychmueller, Steffen; Glare, Paul; Nabal, Maria; Viganò, Antonio; Larkin, Philip; De Conno, Franco; Hanks, Geoffrey; Kaasa, Stein (American Society of Clinical Oncology (ASCO), 2005-09-01)
      Purpose To offer evidence-based clinical recommendations concerning prognosis in advanced cancer patients. Methods A Working Group of the Research Network of the European Association for Palliative Care identified clinically ...

    • Spinal metastatic disease: a review of the role of the multidisciplinary team 

      Curtin, Mark; Piggott, Robert P; Murphy, Evelyn P; Munigangaiah, Sudarshan; Baker, Joseph F; McCabe, John P; Devitt, Aiden (Wiley-Blackwell, 2017-05-01)
      Historically, a simple approach centered on palliation was applicable to the majority of patients with metastatic spinal disease. With advances in diagnosis and treatment, a more complicated algorithm has devolved requiring ...

    • Stress and self-efficacy predict psychological adjustment at diagnosis of prostate cancer 

      Curtis, Ruth; Groarke, AnnMarie; Sullivan, Frank (Springer Nature, 2014-07-04)
      Prostate cancer is the most frequently non-skin cancer diagnosed among men. Diagnosis, a significant burden, generates many challenges which impact on emotional adjustment and so warrants further investigation. Most studies ...

    • Systemic mirnas as potential biomarkers for malignancy 

      Healy, N.A.; Heneghan, H.M.; Miller, N.; Osborne, C.K.; Schiff, R.; Kerin, M.J. (Wiley-Blackwell, 2012-07-30)
      MiRNAs are a class of short, endogenous, single-stranded RNA molecules that play a role in the regulation of gene expression. They have been shown to modulate a number of cellular processes including cell differentiation, ...

    • Targeted resequencing of the micrornaome and 3′utrome reveals functional germline dna variants with altered prevalence in epithelial ovarian cancer 

      Chen, X; Paranjape, T; Stahlhut, C; McVeigh, T; Keane, F; Nallur, S; Miller, N; Kerin, M; Deng, Y; Yao, X; Zhao, H; Weidhaas, J B; Slack, F J (Springer Nature, 2014-06-09)
      Ovarian cancer is a major cause of cancer deaths, yet there have been few known genetic risk factors identified, the best known of which are disruptions in protein coding sequences (BRCA1 and 2). Recent findings indicate ...

    • Targeting the ep1 receptor reduces fas ligand expression and increases the antitumor immune response in anin vivomodel of colon cancer 

      O'Callaghan, Grace; Ryan, Aideen; Neary, Peter; O'Mahony, Caitlin; Shanahan, Fergus; Houston, Aileen (Wiley-Blackwell, 2013-03-04)
      Despite studies demonstrating that inhibition of cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) has significant chemotherapeutic benefits in vitro and in vivo, inhibition of COX enzymes is associated with serious ...

    • The magnitude and characteristics of the population of cancer survivors: using population-based estimates of cancer prevalence to inform service planning for survivorship care 

      Sharp, Linda; Deady, Sandra; Gallagher, Pamela; Molcho, Michal; Pearce, Alison; Alforque Thomas, Audrey; Timmons, Aileen; Comber, Harry (Springer Nature, 2014-10-15)
      Background: Rising cancer incidence and survival mean that the number of cancer survivors is growing. Accumulating evidence suggests many survivors have long-term medical and supportive care needs, and that these needs ...

    • The optimism-neuroticism question: an evaluation based on cardiovascular reactivity in female college students 

      Kennedy, Donna K.; Hughes, Brian M. (Springer Nature, 2004-07-01)
      In order to assess the competing roles of dispositional optimism and neuroticism on reactivity to psychological stress, we selected 50 women (mean age = 18.76 years; SD = 1.9 years) from a screening sample of 150 college ...

    • The pyrrolo-1,5-benzoxazepine, pbox-15, enhances trail-induced apoptosis by upregulation of dr5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells 

      NATHWANI, SEEMA-MARIA; GREENE, LISA M.; BUTINI, STEFANIA; CAMPIANI, GIUSEPPE; WILLIAMS, D. CLIVE; SAMALI, AFSHIN; SZEGEZDI, EVA; ZISTERER, DANIELA M. (Spandidos Publications, 2016-05-11)
      Apoptotic defects are frequently associated with poor outcome in pediatric acute lymphoblastic leukaemia (ALL) hence there is an ongoing demand for novel strategies that counteract apoptotic resistance. The death ligand ...

    • Trail receptor gene editing unveils trail-r1 as a master player of apoptosis induced by trail and er stres 

      Florent, Dufour; Thibault, Rattier; Andrei Alexandru, Constantinescu; Luciana, Zischler; Aymeric, Morlé; Hazem, Ben Mabrouk; Etienne, Humblin; Guillaume, Jacquemin; Eva, Szegezdi; Fabien, Delacote; Naziha, Marrakchi; Gilles, Guichard; Catherine, Pellat-Deceunyn; Pierre, Vacher; Patrick, Legembre; Carmen, Garrido; Micheau, Olivier (Impact Journals, LLC, 2016-12-27)
      TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion ...