Browsing University of Galway Support Services by Subject "ulk4"

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    • Recurrent deletions of ulk4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility 

      Lang, B.; Pu, J.; Hunter, I.; Liu, M.; Martin-Granados, C.; Reilly, T. J.; Gao, G.-D.; Guan, Z.-L.; Li, W.-D.; Shi, Y.-Y.; He, G.; He, L.; Stefansson, H.; St Clair, D.; Blackwood, D. H.; McCaig, C. D.; Shen, S. (The Company of Biologists, 2013-11-27)
      Although many pathogenic copy number variations (CNVs) are associated with neuropsychiatric diseases, few of them have been functionally characterised. Here we report multiple schizophrenia cases with CNV abnormalities ...

    • ulk4 deficiency leads to hypomyelination in mice 

      Liu, Min; Xu, Ping; Guan, Zhenlong; Qian, Xiaohong; Dockery, Peter; Fitzgerald, Una; O'Brien, Timothy; Shen, Sanbing (Wiley-Blackwell, 2017-10-16)
      Brain nerve fibers are insulated by myelin which is produced by oligodendrocytes. Defects in myelination are increasingly recognized as a common pathology underlying neuropsychiatric and neurodevelopmental disorders, which ...

    • Ulk4 is essential for ciliogenesis and csf flow 

      Liu, M.; Guan, Z.; Shen, Q.; Lalor, P.; Fitzgerald, U.; O'Brien, T.; Dockery, P.; Shen, S. (Society for Neuroscience, 2016-07-20)
      Ciliopathies are an emerging class of devastating disorders with pleiotropic symptoms affecting both the central and peripheral systems and commonly associated with hydrocephalus. Even though ciliary components and three ...

    • Ulk4regulates neural stem cell pool 

      Liu, Min; Guan, Zhenlong; Shen, Qin; Flinter, Frances; Domínguez, Laura; Ahn, Joo Wook; Collier, David A.; O'Brien, Timothy; Shen, Sanbing (Wiley-Blackwell, 2016-06-27)
      The size of neural stem cell (NSC) pool at birth determines the starting point of adult neurogenesis. Aberrant neurogenesis is associated with major mental illness, in which ULK4 is proposed as a rare risk factor. Little ...