Browsing University of Galway Support Services by Subject "glycosylation"
Now showing items 1-14 of 14
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Bfmp: a method for discretizing and visualizing pyranose conformations
(American Chemical Society (ACS), 2014-10-27)We report a new classification method for pyranose ring conformations called Best-fit, Four-Membered Plane (BFMP), which describes pyranose ring conformations based on reference planes defined by four atoms. The method is ... -
Characterizing the diverse mutational pathways associated with r5-tropic maraviroc resistance: hiv-1 that uses the drug-bound ccr5 coreceptor
(American Society for Microbiology, 2015-09-02)Entry inhibitors represent a potent class of antiretroviral drugs that target a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein. Lack of sensitivity can occur due to preexisting virus that uses ... -
Distinctive surface glycosylation patterns associated with mouse and human cd4+ regulatory t cells and their suppressive function
(Frontiers Media SA, 2017-08-21)Regulatory T-cells (Treg) are essential for maintaining immune homeostasis and tolerance. Surface glycosylation is ubiquitous on mammalian cells and regulates diverse biological processes. While it is currently well accepted ... -
Exploitation of spr to investigate the importance of glycan chains in the interaction between lactoferrin and bacteria
(MDPI AG, 2017-06-27)Bovine lactoferrin (LF) has been shown to prevent adhesion to and invasion of mammalian cell lines by pathogenic bacteria, with evidence for direct bacterial binding by the milk glycoprotein. However, the glycosylation ... -
Glycosylation-related gene expression in ht29-mtx-e12 cells upon infection by helicobacter pylori
(Baishideng Publishing Group Inc., 2017-10-07)AIM To identify glycosylation-related genes in the HT29 derivative cell line, HT29-MTX-E12, showing differential expression on infection with Helicobacter pylori (H. pylori). METHODS Polarised HT29-MTX-E12 cells were ... -
Negative ion cid fragmentation of o-linked oligosaccharide aldoses—charge induced and charge remote fragmentation
(Springer Nature, 2011-03-31)Collision induced dissociation (CID) fragmentation was compared between reducing and reduced sulfated, sialylated, and neutral O-linked oligosaccharides. It was found that fragmentation of the [M - H](-) ions of aldoses ... -
Presence of terminal n-acetylgalactosamineβ1-4n-acetylglucosamine residues on o-linked oligosaccharides from gastric muc5ac: involvement in helicobacter pylori colonization?
(Oxford University Press (OUP), 2012-04-26)Isolation of MUC5AC mucins from the gastric mucosa from two secretor individuals (one from normal mucosa from a patient with gastric cancer and one from a control) showed different abilities to bind and induce the proliferation ... -
Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment
(Frontiers Media SA, 2017-10-30)Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ... -
Salivary muc7 is a major carrier of blood group i type o-linked oligosaccharides serving as the scaffold for sialyl lewis x
(Oxford University Press (OUP), 2008-11-29)Isolation of salivary MUC7 with gel electrophoresis allowed analysis by LC-MS and LC-MS(2) of released O-linked oligosaccharides and a thorough description of the glycosylation of this molecule, where high-molecular-weight ... -
Structural and functional characteristics of bovine milk protein glycosylation
(Oxford University Press (OUP), 2014-01-06)Most secreted and cell membrane proteins in mammals are glycosylated. Many of these glycoproteins are also prevalent in milk and play key roles in the biomodulatory properties of milk and ultimately in determining milk's ... -
Targeting selectins and their ligands in cancer
(Frontiers Media SA, 2016-04-18)Aberrant glycosylation is a hallmark of cancer cells with increased evidence pointing to a role in tumor progression. In particular, aberrant sialylation of glycoproteins and glycolipids has been linked to increased immune ... -
Temporal alterations in the bovine buttermilk glycome from parturition to milk maturation
(Elsevier BV, 2016-11-01) -
The sialyltransferase st3gal6 influences homing and survival in multiple myeloma
(American Society of Hematology, 2014-07-24)Glycosylation is a stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process, especially increased sialylation, have been associated with malignant transformation ... -
Unique glycosignature for intervertebral disc and articular cartilage cells and tissues in immaturity and maturity
(Springer Nature, 2016-03-11)In this study, on/off markers for intervertebral disc (IVD) and articular cartilage (AC) cells (chondrocytes) and distinct glycoprofiles of cell and tissue-types were identified from immaturity to maturity. Three and eleven ...