Browsing University of Galway Support Services by Subject "cell therapy"

Now showing items 1-9 of 9

    • Biopolymer-based nanoparticles for cystic fibrosis lung gene therapy studies 

      Fernández Fernández, Elena; Santos-Carballal, Beatriz; de Santi, Chiara; Ramsey, Joanne; MacLoughlin, Ronan; Cryan, Sally-Ann; Greene, Catherine (MDPI AG, 2018-01-13)
      Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells ...

    • Concise review: adult mesenchymal stromal cell therapy for inflammatory diseases: how well are we joining the dots? 

      Griffin, Matthew D.; Elliman, Stephen J.; Cahill, Emer; English, Karen; Ceredig, Rhodri; Ritter, Thomas (Wiley-Blackwell, 2013-10-01)
      Mesenchymal stromal (stem) cells (MSCs) continue to be a strong area of focus for academic- and industry-based researchers who share the goal of expanding their therapeutic use for diverse inflammatory and immune-mediated ...

    • Delivery of strail variants by mscs in combination with cytotoxic drug treatment leads to p53-independent enhanced antitumor effects 

      Yu, R; Deedigan, L; Albarenque, S M; Mohr, A; Zwacka, R M (Springer Nature, 2013-02-01)
      Mesenchymal stem cells (MSCs) are able to infiltrate tumor tissues and thereby effectively deliver gene therapeutic payloads. Here, we engineered murine MSCs (mMSCs) to express a secreted form of the TNF-related ...

    • Exogenous mir-29b delivery through a hyaluronan-based injectable system yields functional maintenance of the infarcted myocardium 

      Monaghan, Michael G.; Holeiter, Monika; Brauchle, Eva; Layland, Shannon L.; Lu, Yan; Deb, Arjun; Pandit, Abhay; Nsair, Ali; Schenke-Layland, Katja (Mary Ann Liebert Inc, 2017-05-22)
      Myocardial infarction (MI) results in debilitating remodeling of the myocardial extracellular matrix (ECM). In this proof-of-principle study it was sought to modulate this aggressive remodeling by injecting a hyaluronic ...

    • Minimum information about t regulatory cells: a step toward reproducibility and standardization 

      Fuchs, Anke; Gliwiński, Mateusz; Grageda, Nathali; Spiering, Rachel; Abbas, Abul K.; Appel, Silke; Bacchetta, Rosa; Battaglia, Manuela; Berglund, David; Blazar, Bruce; Bluestone, Jeffrey A.; Bornhäuser, Martin; ten Brinke, Anja; Brusko, Todd M.; Cools, Nathalie; Cuturi, Maria Cristina; Geissler, Edward; Giannoukakis, Nick; Gołab, Karolina; Hafler, David A.; van Ham, S. Marieke; Hester, Joanna; Hippen, Keli; Di Ianni, Mauro; Ilic, Natasa; Isaacs, John; Issa, Fadi; Iwaszkiewicz-Grześ, Dorota; Jaeckel, Elmar; Joosten, Irma; Klatzmann, David; Koenen, Hans; van Kooten, Cees; Korsgren, Olle; Kretschmer, Karsten; Levings, Megan; Marek-Trzonkowska, Natalia Maria; Martinez-Llordella, Marc; Miljkovic, Djordje; Mills, Kingston H.G.; Miranda, Joana P.; Piccirillo, Ciriaco A.; Putnam, Amy L.; Ritter, Thomas; Roncarolo, Maria Grazia; Sakaguchi, Shimon; Sánchez-Ramón, Silvia; Sawitzki, Birgit; Sofronic-Milosavljevic, Ljiljana; Sykes, Megan; Tang, Qizhi; Vives-Pi, Marta; Waldmann, Herman; Witkowski, Piotr; Wood, Kathryn J.; Gregori, Silvia; Hilkens, Catharien M. U.; Lombardi, Giovanna; Lord, Phillip; Martinez-Caceres, Eva M.; Trzonkowski, Piotr (Frontiers Media SA, 2018-01-15)
      Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing ...

    • Minimum information about tolerogenic antigen-presenting cells (mitap): a first step towards reproducibility and standardisation of cellular therapies 

      Lord, Phillip; Spiering, Rachel; Aguillon, Juan C.; Anderson, Amy E.; Appel, Silke; Benitez-Ribas, Daniel; ten Brinke, Anja; Broere, Femke; Cools, Nathalie; Cuturi, Maria Cristina; Diboll, Julie; Geissler, Edward K.; Giannoukakis, Nick; Gregori, Silvia; van Ham, S. Marieke; Lattimer, Staci; Marshall, Lindsay; Harry, Rachel A.; Hutchinson, James A.; Isaacs, John D.; Joosten, Irma; van Kooten, Cees; Lopez Diaz de Cerio, Ascension; Nikolic, Tatjana; Oral, Haluk Barbaros; Sofronic-Milosavljevic, Ljiljana; Ritter, Thomas; Riquelme, Paloma; Thomson, Angus W.; Trucco, Massimo; Vives-Pi, Marta; Martinez-Caceres, Eva M.; Hilkens, Catharien M.U. (PeerJ, 2016-08-30)
      Cellular therapies, with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation The methodologies ...

    • Regulating immunogenicity and tolerogenicity of bone marrow-derived dendritic cells through modulation of cell surface glycosylation by dexamethasone treatment 

      Lynch, Kevin; Treacy, Oliver; Gerlach, Jared Q.; Annuk, Heidi; Lohan, Paul; Cabral, Joana; Joshi, Lokesh; Ryan, Aideen E.; Ritter, Thomas (Frontiers Media SA, 2017-10-30)
      Dendritic cellular therapies and dendritic cell vaccines show promise for the treatment of autoimmune diseases, the prolongation of graft survival in transplantation, and in educating the immune system to fight cancers. ...

    • The vasoreparative function of myeloid angiogenic cells (macs) is impaired in diabetes through the induction of il1β 

      Chambers, Sarah EJ.; O'Neill, Christina L.; Guduric-Fuchs, Jasenka; McLoughlin, Kiran J.; Liew, Aaron; Egan, Aoife M.; O'Brien, Timothy; Stitt, Alan W.; Medina, Reinhold J. (Wiley-Blackwell, 2018-02-27)
      Myeloid angiogenic cells (MACs) promote revascularization through the paracrine release of angiogenic factors and have been harnessed as therapeutic cells for many ischemic diseases. However, their proangiogenic properties ...

    • Vil-10-overexpressing human mscs modulate naïve and activated t lymphocytes following induction of collagenase-induced osteoarthritis 

      Farrell, Eric; Fahy, Niamh; Ryan, Aideen E; Flatharta, Cathal O; O’Flynn, Lisa; Ritter, Thomas; Murphy, J Mary (Springer Nature, 2016-05-18)
      Background: Recent efforts in osteoarthritis (OA) research have highlighted synovial inflammation and involvement of immune cells in disease onset and progression. We sought to establish the in-vivo immune response in ...