Now showing items 1-2 of 2

    • Evolutionary trade-offs associated with loss of pmrb function in host-adapted pseudomonas aeruginosa 

      Bricio-Moreno, Laura; Sheridan, Victoria H.; Goodhead, Ian; Armstrong, Stuart; Wong, Janet K.L.; Waters, Elaine M.; Sarsby, Joscelyn; Panagiotou, Stavros; Dunn, James; Chakraborty, Adrita; Fang, Yongliang; Griswold, Karl E.; Winstanley, Craig; Fothergill, Joanne L.; Kadioglu, Aras; Neill, Daniel R. (Springer Nature, 2018-07-06)
      Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally-evolved ...
    • Redeploying β-lactam antibiotics as a novel antivirulence strategy for the treatment of methicillin-resistantstaphylococcus aureusinfections 

      Waters, Elaine M.; Rudkin, Justine K.; Coughlan, Simone; Clair, Geremy C.; Adkins, Joshua N.; Gore, Suzanna; Xia, Guoqing; Black, Nikki S.; Downing, Tim; O'Neill, Eoghan; Kadioglu, Aras; O'Gara, James P. (Oxford University Press (OUP), 2016-11-14)
      Innovative approaches to the use of existing antibiotics is an important strategy in efforts to address the escalating antimicrobial resistance crisis. We report a new approach to the treatment of methicillin-resistant ...