Browsing University of Galway Support Services by Author "Gaboriau, David"
Now showing items 1-4 of 4
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Centriole splitting caused by loss of the centrosomal linker protein c-nap1 reduces centriolar satellite density and impedes centrosome amplification
Flanagan, Anne-Marie; Stavenschi, Elena; Basavaraju, Shivakumar; Gaboriau, David; Hoey, David A.; Morrison, Ciaran G. (American Society for Cell Biology (ASCB), 2017-01-18)Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker ... -
Centrobin controls primary ciliogenesis in vertebrates
Ogungbenro, Yetunde Adesanya; Tena, Teresa Casar; Gaboriau, David; Lalor, Pierce; Dockery, Peter; Philipp, Melanie; Morrison, Ciaran G. (Rockefeller University Press, 2018-02-13)The BRCA2 interactor, centrobin, is a centrosomal protein that has been implicated in centriole duplication and microtubule stability. We used genome editing to ablate CNT ROB in hTERT-RPE1 cells and observed an increased ... -
Cep164-null cells generated by genome editing show a ciliation defect with intact dna repair capacity
Daly, Owen M.; Gaboriau, David; Karakaya, Kadin; King, Sinéad; Dantas, Tiago J.; Lalor, Pierce; Dockery, Peter; Krämer, Alwin; Morrison, Ciaran G. (The Company of Biologists, 2016-03-10)Primary cilia are microtubule structures that extend from the distal end of the mature, mother centriole. CEP164 is a component of the distal appendages carried by the mother centriole that is required for primary cilium ... -
The deubiquitinase usp9x maintains dna replication fork stability and dna damage checkpoint responses by regulating claspin during s-phase
McGarry, Edel; Gaboriau, David; Rainey, Michael D.; Restuccia, Umberto; Bachi, Angela; Santocanale, Corrado (American Association for Cancer Research (AACR), 2016-02-26)