Browsing University of Galway Support Services by Subject "unfolded protein response"
Now showing items 1-19 of 19
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A lifetime of stress: atf6 in development and homeostasis
(Springer Nature, 2018-05-25)Background: Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked ... -
Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under er stress conditions
(Informa UK Limited, 2014-11-02)Endoplasmic reticulum (ER) stress-induced cell death is normally associated with activation of the mitochondrial apoptotic pathway, which is characterized by CYCS (cytochrome c, somatic) release, apoptosome formation, and ... -
Deregulated expression of the hsp40 family members auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in ph+ leukemia
(Springer Nature, 2015-12-01)Background: Proteostasis is defined by the orchestrated control of anabolic and catabolic protein pathways. Disruption of proteostasis results in cell stress and adaptation to proteostasis imbalance is mediated by adaptive ... -
Disruption of microrna biogenesis confers resistance to er stress-induced cell death upstream of the mitochondrion
(Public Library of Science (PLoS), 2013-08-19)Global downregulation of microRNAs (miRNAs) is a common feature of human tumors and has been shown to enhance cancer progression. Several components of the miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown ... -
Drugging the unfolded protein response in acute leukemias
(Springer Nature, 2015-07-16)The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1 alpha, PERK, and ATF6 alpha. Studies described the UPR as a critical ... -
Dual ire1 rnase functions dictate glioblastoma development
(EMBO, 2018-01-08)Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ... -
Endoplasmic reticulum stress-mediated induction of sestrin 2 potentiates cell survival
(Impact Journals, LLC, 2016-02-22)Upregulation of SESTRIN 2 (SESN2) has been reported in response to diverse cellular stresses. In this study we demonstrate SESTRIN 2 induction following endoplasmic reticulum (ER) stress. ER stress-induced increases in ... -
Heat shock preconditioning protects against er stress-induced apoptosis through the regulation of the bh3-only protein bim
(Wiley-Blackwell, 2014-01-01) -
Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats
(American Physiological Society, 2012-10-11)Nurnberger S, Miller I, Duvigneau JC, Kavanagh ET, Gupta S, Hartl RT, Hori O, Gesslbauer B, Samali A, Kungl A, Redl H, Kozlov AV. Impairment of endoplasmic reticulum in liver as an early consequence of the systemic ... -
Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
(Oxford University Press (OUP), 2008-03-01)Activation of endoplasmic reticulum (ER) stress-related cell signals has been reported in several neurologic disorders and may contribute to neurodegeneration. Endoplasmic reticulum stress is also linked to ischemic injury. ... -
Mediators of endoplasmic reticulum stress-induced apoptosis
(Wiley-Blackwell, 2006-09-01)The efficient functioning of the endoplasmic reticulum ( ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ... -
Mirna signature of unfolded protein response in h9c2 rat cardiomyoblasts
(Springer Nature, 2014-01-01)Background: Glucose and oxygen deprivation during ischemia is known to affect the homeostasis of the endoplasmic reticulum (ER) in ways predicted to activate the unfolded protein response (UPR). Activation of UPR signalling ... -
Ncoa3 coactivator is a transcriptional target of xbp1 and regulates perk–eif2α–atf4 signalling in breast cancer
(Springer Nature, 2016-04-25)XBP1 is a multitasking transcription factor and a key component of the unfolded protein response (UPR). Despite the wealth of knowledge about the role of XBP1 in luminal/ER-positive breast cancer, not much is known about ... -
Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrionviaregulation of bim
(Wiley-Blackwell, 2008-02-06)This study examined how the neurotrophin, nerve growth factor (NGF), protects PC12 cells against endoplasmic reticulum (ER) stress-induced apoptosis. ER stress was induced using thapsigargin (TG) that inhibits the ... -
Noxa contributes to the sensitivity of perk-deficient cells to er stress
(Wiley-Blackwell, 2012-10-12) -
Perk is required at the er-mitochondrial contact sites to convey apoptosis after ros-based er stress
(Springer Nature, 2012-06-15)Endoplasmic reticulum stress is emerging as an important modulator of different pathologies and as a mechanism contributing to cancer cell death in response to therapeutic agents. In several instances, oxidative stress and ... -
Perk-dependent repression of mir-106b-25 cluster is required for er stress-induced apoptosis
(Springer Nature, 2012-06-01)Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be ... -
The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress
(Wiley-Blackwell, 2012-02-29)One of the early cellular responses to endoplasmic reticulum (ER) stress is the activation of the unfolded protein response (UPR). ER stress and the UPR are both implicated in numerous human diseases and pathologies. In ... -
Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (sparus aurata l.)
(Springer Nature, 2010-01-01)Background: Selection programs for growth and stress traits in cultured fish are fundamental to the improvement of aquaculture production. The gilthead sea bream ( Sparus aurata) is the main aquacultured species in the ...