Now showing items 1-5 of 5

    • Assessing methods to specify the target difference for a randomised controlled trial: delta (difference elicitation in trials) review 

      Cook, Jonathan; Hislop, Jennifer; Adewuyi, Temitope; Harrild, Kirsten; Altman, Douglas; Ramsay, Craig; Fraser, Cynthia; Buckley, Brian; Fayers, Peter; Harvey, Ian; Briggs, Andrew; Norrie, John; Fergusson, Dean; Ford, Ian; Vale, Luke (National Institute for Health Research, 2014-01-01)
      Background: The randomised controlled trial (RCT) is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to the design and validity of a RCT is a calculation of ...
    • Immunological aspects of allogeneic mesenchymal stem cell therapies 

      Griffin, Matthew D.; Ritter, Thomas; Mahon, Bernard P. (Mary Ann Liebert Inc, 2010-12-01)
      Allogeneic mesenchymal stem or stromal cells (MSCs) are proposed as cell therapies for degenerative, inflammatory, and autoimmune diseases. The feasibility of allogeneic MSC therapies rests heavily on the concept that these ...
    • The comet handbook: version 1.0 

      Williamson, Paula R.; Altman, Douglas G.; Bagley, Heather; Barnes, Karen L.; Blazeby, Jane M.; Brookes, Sara T.; Clarke, Mike; Gargon, Elizabeth; Gorst, Sarah; Harman, Nicola; Kirkham, Jamie J.; McNair, Angus; Prinsen, Cecilia A. C.; Schmitt, Jochen; Terwee, Caroline B.; Young, Bridget (Springer Nature, 2017-06-01)
      The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to influence policy and practice, the outcomes need to ...
    • The importance of mechnikovs thorn for an improved understanding of 21st century medicine and immunology: a view from the eye 

      McGonagle, D.; Georgouli, T. (Wiley-Blackwell, 2008-08-01)
      In 1908, Ehrlich and Mechnikov shared the Nobel Prize in Medicine for their independent studies that set the scene for the modern understanding of innate and adaptive immunity. However, 20th century immunology thinking was ...
    • Women, kidney disease, and pregnancy 

      Smyth, Andrew; Radovic, Milan; Garovic, Vesna D. (Elsevier BV, 2013-09-01)