Browsing University of Galway Support Services by Subject "saccharomyces-cerevisiae srs2"

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    • Rtel1 inhibits trinucleotide repeat expansions and fragility 

      Frizzell, Aisling; Nguyen, Jennifer H.G.; Petalcorin, Mark I.R.; Turner, Katherine D.; Boulton, Simon J.; Freudenreich, Catherine H.; Lahue, Robert S. (Elsevier BV, 2014-03-01)
      Human RTEL1 is an essential, multifunctional helicase that maintains telomeres, regulates homologous recombination, and helps prevent bone marrow failure. Here, we show that RTEL1 also blocks trinucleotide repeat expansions, ...