Browsing University of Galway Support Services by Subject "macrophages"
Now showing items 1-10 of 10
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Biological activities of lipopolysaccharides are determined by the shape of their lipid a portion
(Wiley-Blackwell, 2000-04-01)Lipopolysaccharide (LPS) represents a major virulence factor of Gram-negative bacteria ('endotoxin') that can cause septic shock in mammals including man. The lipid anchor of LPS to the outer membrane, lipid A, has a ... -
Effect of helicobacter pylori lipopolysaccharide (lps) and lps derivatives on the production of tissue factor and plasminogen activator inhibitor type 2 by human blood mononuclear cells
(Oxford University Press (OUP), 1996-12-01)Different Helicobacter pylori lipopolysaccharides (LPSs) and LPS-derivatives were studied for their ability to induce the production of procoagulant activity (PCA) and plasminogen activator inhibitor type 2 (PAI-2) by human ... -
Inhibition of polymethylmethacrylate particle-induced monocyte activation and il-1β and tnf-α expression by the antioxidant agent n-acetylcysteine
(Informa UK Limited, 2002-01-01)We investigated the effectiveness of an antioxidant agent, N-acetylcysteine (NAC), in suppressing macrophage activation and mediator release in response to particulate debris. Polymethylmethacrylate (PMMA) particle-stimulated ... -
Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
(BMJ, 2011-11-21)Background Bone-marrow derived mesenchymal stem cells (MSCs) reduce the severity of evolving acute lung injury (ALI), but their ability to repair the injured lung is not clear. A study was undertaken to determine the ... -
Mononuclear phagocyte depletion strategies in models of acute kidney disease: what are they trying to tell us?
(Elsevier BV, 2012-10-01)Mononuclear phagocytes (macrophages, dendritic cells, and monocytes) play a complex role in kidney disease. Techniques for selectively depleting them in rodents have made important contributions but have also generated ... -
Proinflammatory action of the antiinflammatory drug infliximab in tumor necrosis factor receptor-associated periodic syndrome
(Wiley-Blackwell, 2009-02-01)Objective. Tumor necrosis factor receptor (TNFR) -associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory condition caused by mutations in the TNFRSFIA gene. Unlike other autoinflammatory diseases ... -
Targeting the ep1 receptor reduces fas ligand expression and increases the antitumor immune response in anin vivomodel of colon cancer
(Wiley-Blackwell, 2013-03-04)Despite studies demonstrating that inhibition of cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) has significant chemotherapeutic benefits in vitro and in vivo, inhibition of COX enzymes is associated with serious ... -
The anti-inflammatory effect of algae-derived lipid extracts on lipopolysaccharide (lps)-stimulated human thp-1 macrophages
(MDPI AG, 2015-08-20)Algae contain a number of anti-inflammatory bioactive compounds such as omega-3 polyunsaturated fatty acids (n-3 PUFA) and chlorophyll a, hence as dietary ingredients, their extracts may be effective in chronic inflammation-linked ... -
The role of c1q in recognition of apoptotic epithelial cells and inflammatory cytokine production by phagocytes during helicobacter pylori infection
(Springer Nature, 2015-09-08)Background: Gastric epithelial cells (GECs) undergo apoptosis during H. pylori infection and phagocytes within the mucosa engulf these cells. The recognition and clearance of apoptotic cells is a multifactorial process, ...