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dc.contributor.authorRea, Kieranen
dc.contributor.authorRoche, Michelleen
dc.contributor.authorFinn, David P.en
dc.date.accessioned2010-04-16T09:00:21Zen
dc.date.available2010-04-16T09:00:21Zen
dc.date.issued2007en
dc.identifier.citationRea K., Roche M. & Finn D.P. (2007). Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate. British Journal of Pharmacology, 152(5): 633-48.en
dc.identifier.urihttp://hdl.handle.net/10379/838en
dc.description.abstractRecent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. This article aims to review this evidence in the context of its implications for pain. We first provide a brief overview of supraspinal regulation of nociception, followed by a review of the evidence that the brain's endocannabinoid system modulates nociception. We look in detail at regulation of supraspinal GABAergic and glutamatergic neurons by the endocannabinoid system and by exogenously administered cannabinoids. Finally, we review the evidence that cannabinoid-mediated modulation of pain involves modulation of GABAergic and glutamatergic neurotransmission in key brain regions.en
dc.description.sponsorshipSFIen
dc.formatapplication/pdfen
dc.language.isoenen
dc.subjectPainen
dc.subjectBrainen
dc.subjectCannabinoidsen
dc.subjectGABAen
dc.subjectGlutamateen
dc.subjectNeurotransmissionen
dc.subjectNociceptionen
dc.subjectPharmacology & Therapeuticsen
dc.titleSupraspinal modulation of pain by cannabinoids: the role of GABA and glutamateen
dc.typeArticleen
dc.local.publishedsourcehttp://dx.doi.org/10.1038/sj.bjp.0707440en
dc.description.peer-reviewedpeer-revieweden
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