Now showing items 1-2 of 2

  • DNA mediated chromatin pull-down for the study of chromatin replication 

    Kliszczak, Anna E.; Rainey, Michael D.; Harhen, Brendan; Santocanale, Corrado (2011)
    Chromatin replication involves duplicating DNA while maintaining epigenetic information. These processes are critical for genome stability and for preserving cell-type identity. Here we describe a simple experimental ...
  • Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint 

    Maffini, Stefano; Rainey, Michael D.; Kaczmarczyk, Agnieszka; O'Connor, Aisling; Gaboriau, David; Musacchio, Andrea; Santocanale, Corrado (Company of Biologists, 2016)
    During mitotic arrest induced by microtubule targeting drugs, the weakening of the spindle assembly checkpoint (SAC) allows cells to progress through the cell cycle without chromosome segregation occurring. PLK1 kinase ...