Now showing items 1-7 of 7

  • Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells 

    Chandran, Sreenath; Cairns, Michael T.; O'Brien, Margaret; O'Connell, Enda; Mashayekhi, Kaveh; Smith, Terry J. (American Physiological Society, 2016-01-01)
    A transcriptomic analysis of cultured human uterine smooth muscle cells (hUtSMCs) was performed to examine gene expression profiles in smooth muscle in an environment containing the two major steroid hormones that regulate ...
  • Expression of RHOGTPase regulators in human myometrium 

    Mullins, Brian; O'Brien, Margaret; Flynn, David; Smith, Terry; Morrison, John J. (Reproductive Biology and Endocrinology, 2008-01-11)
    Background: RHOGTPases play a significant role in modulating myometrial contractility in uterine smooth muscle. They are regulated by at least three families of proteins, RHO guanine nucleotide exchange factors (RHOGEFs), ...
  • Ghrelin in the human myometrium 

    O'Brien, Margaret; Earley, Padraig; Morrison, John J.; Smith, Terry (BioMed Central Ltd, 2010-03-29)
    Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously determined that ...
  • Ghrelin in the human myometrium 

    Smith, Terry; O'Brien, Margaret; Morrison, John J. (2010)
    Background: Ghrelin is a 28-amino acid octanolyated peptide, synthesised primarily in the stomach. It stimulates growth hormone release, food intake and exhibits many other diverse effects. Our group have previously ...
  • Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin 

    Morrison, John J.; Smith, Terry; O'Brien, Margaret; Fitzgibbon, Joan (Springer, 2009-01-08)
    Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are ...
  • Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin 

    Fitzgibbon, Joan; Morrison, John J.; Smith, Terry; O'Brien, Margaret (BioMed Central, 2009-01-08)
    Background: Preterm labour occurs in approximately 10% of pregnancies and is a major cause of infant morbidity and mortality. However, the pathways involved in regulating contractility in normal and preterm labour are not ...
  • Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design 

    O'Brien, Margaret; Smith, Terry (National Academy Of Sciences Of The United States Of America, 2013-10-23)
    Cyclotides are plant peptides comprising a circular backbone and three conserved disulfide bonds that confer them with exceptional stability. They were originally discovered in Oldenlandia affinis based on their use in ...