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dc.contributor.authorButler, Ryan K.en
dc.contributor.authorFinn, David P.en
dc.date.accessioned2010-03-12T12:59:15Zen
dc.date.available2010-03-12T12:59:15Zen
dc.date.issued2009en
dc.identifier.urihttp://hdl.handle.net/10379/761en
dc.description.abstractFor over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, ¿-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.en
dc.description.sponsorshipSFIen
dc.formatapplication/pdfen
dc.language.isoenen
dc.publisherButler, R. K. & Finn, D.P. (2009). Stress-induced analgesia. Progress in Neurobiology, 88, 184-202.en
dc.subjectPainen
dc.subjectStress-induced analgesiaen
dc.subjectFearen
dc.subjectRodenten
dc.subjectHumanen
dc.subject.lcshPain treatmenten
dc.subject.lcshAnalgesiaen
dc.subject.lcshAnalgesiaen
dc.titleStress-induced analgesia.en
dc.typeArticleen
dc.local.publishedsourcehttp://dx.doi.org/10.1016/j.pneurobio.2009.04.003en
dc.description.peer-reviewedpeer-revieweden
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