Now showing items 1-8 of 8

    • In vivo correlation mapping microscopy 

      McGrath, James; Alexandrov, Sergey; Owens, Peter; Subhash, Hrebesh; Leahy, Martin (Society of Photo-optical Instrumentation Engineers (SPIE), 2016-03)
      To facilitate regular assessment of the microcirculation in vivo, noninvasive imaging techniques such as nailfold capillaroscopy are required in clinics. Recently, a correlation mapping technique has been applied to optical ...
    • Investigation of depth-resolved nanoscale structural changes in regulated cell proliferation and chromatin decondensation 

      Uttam, Shikhar; Bista, Rajan K.; Staton, Kevin; Alexandrov, Sergey; Choi, Serah; Bakkenist, Christopher J.; Hartman, Douglas J.; Brand, Randall E.; Liu, Yang (2013)
      We present depth-resolved spatial-domain low-coherence quantitative phase microscopy, a simple approach that utilizes coherence gating to construct a depth-resolved structural feature vector quantifying sub-resolution axial ...
    • Investigation of nanoscale structural alterations of cell nucleus as an early sign of cancer 

      Alexandrov, Sergey (BioMed Central, 2014)
      Background: The cell and tissue structural properties assessed with a conventional bright-field light microscope play a key role in cancer diagnosis, but they sometimes have limited accuracy in detecting early-stage cancers ...
    • Nano-sensitive optical coherence tomography 

      Alexandrov, Sergey; Subhash, Hrebesh M.; Zam, Azhar; Leahy, Martin (Royal Society of Chemistry, 2014)
      Depth resolved label-free detection of structural changes with nanoscale sensitivity is an outstanding problem in the biological and physical sciences and has significant applications in both the fundamental research and ...
    • Nanosensitive optical coherence tomography for the study of changes in static and dynamic structures 

      Subhash, Hrebesh M.; Leahy, Martin; Alexandrov, Sergey (IOP Science, 2014-03-06)
      We briefly discuss the principle of image formation in Fourier domain optical coherence tomography (OCT). The theory of a new approach to improve dramatically the sensitivity of conventional OCT is described. The approach ...
    • Novel approach for label free super-resolution imaging in far field 

      Alexandrov, Sergey; McGrath, James; Hrebesh, Subhash; Leahy, Martin (Nature Publishing Group, 2015)
      Progress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the structures with high resolution. Recently, the ...
    • Performance review of multiple reference versus time domain optical coherence tomography 

      Neuhaus, Kai; McNamara, Paul M.; Alexandrov, Sergey; O'Gorman, Seán; Hogan, Josh; Wilson, Carol; Leahy, Martin J. (IEEE, 2018-04-19)
      We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT). The noise characteristics were modeled based on the TD-OCT noise ...
    • Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization 

      Alexandrov, Sergey; McNamara, Paul M.; Das, Nandan; Zhou, Yi; Lynch, Gillian; Hogan, Josh; Leahy, Martin (AIP Publishing, 2019-09-16)
      Most of the fundamental pathological processes in living tissues exhibit changes at the nanoscale. Noninvasive, label-free detection of structural changes in biological samples pose a significant challenge to both researchers ...