Browsing Pharmacology & Therapeutics by Author "Rea, Kieran"
Now showing items 1-7 of 7
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Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: Opioid receptor dependency and molecular correlates
Butler, Ryan K.; Rea, Kieran; Lang, Yvonne; Gavin, Aisling M.; Finn, David P. (International Association for the Study of Pain, 2008-12)The opioid and endocannabinoid systems mediate analgesia expressed upon re-exposure to a contextually aversive stimulus (fear-conditioned analgesia; FCA), and modulate the mitogen-activated protein kinase (MAPK) pathway. ... -
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
Rea, Kieran; Olango, Weredeselam M.; Harhen, Brendan; Kerr, Daniel M.; Galligan, Rachel; Fitzgerald, Sean; Moore, Maeve; Roche, Michelle; Finn, David P. (Elsevier, 2012-12-31)The basolateral amygdala (BLA) is a key substrate facilitating the expression of fear-conditioned analgesia (FCA). However, the neurochemical mechanisms in the BLA which mediate this potent suppression of pain responding ... -
Genotype-dependent responsivity to inflammatory pain: A role for TRPV1 in the periaqueductal grey
Madasu, Manish K.; Okine, Bright N.; Olango, Weredeselam M.; Rea, Kieran; Lenihan, Róisín; Roche, Michelle; Finn, David P. (Elsevier, 2016-08-09)Negative affective state has a significant impact on pain, and genetic background is an important moderating influence on this interaction. The Wistar-Kyoto (WKY) inbred rat strain exhibits a stress-hyperresponsive, ... -
Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli
Rea, Kieran; Olango, Weredeselam M.; Okine, Bright N.; Madasu, Manish K.; McGuire, Iseult C.; Coyle, Kathleen; Harhen, Brendan; Roche, Michelle; Finn, David P. (International Association for the Study of Pain, 2014-01)Pain is both a sensory and an emotional experience, and is subject to modulation by a number of factors including genetic background modulating stress/affect. The Wistar-Kyoto (WKY) rat exhibits a stress-hyper-responsive ... -
Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala
Rea, Kieran; Roche, Michelle; Finn, David P. (Elsevier, 2011-04)Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA ... -
The prefrontal cortical endocannabinoid system modulates fear–pain interactions in a subregion‐specific manner
Rea, Kieran; McGowan, Fiona; Corcoran, Louise; Roche, Michelle; Finn, David P. (Wiley, 2018-05-30)Background and Purpose The emotional processing and coordination of top‐down responses to noxious and conditioned aversive stimuli involves the medial prefrontal cortex (mPFC). Evidence suggests that subregions of the ... -
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
Rea, Kieran; Roche, Michelle; Finn, David P. (2007)Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. ...