Browsing School of Medicine by Issue Date
Now showing items 1-20 of 336
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Circuitry underlying regulation of the serotonergic system by swim stress
(Society for Neuroscience, 2003-02-01)The dorsal raphe nucleus (DR)–serotonin (5-HT) system has been implicated in depression and is dramatically affected by swim stress, an animal model with predictive value for antidepressants. Accumulating evidence implicates ... -
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats
(Elsevier, 2003-07-31)The analgesic potential of cannabinoids may be hampered by their ability to produce aversive emotion when administered systemically. We investigated the hypothesis that the midbrain periaqueductal grey (PAG) is a common ... -
Evidence for differential modulation of conditioned aversion and fear‐conditioned analgesia by CB1 receptors
(Wiley, 2004-07-15)Fear‐conditioned analgesia is an important survival response mediated by substrates controlling nociception and aversion. Cannabinoid1 (CB1) receptors play an important role in nociception and aversion. However, their role ... -
The SPHERE Study. Secondary prevention of heart disease in general practice: protocol of a randomised controlled trial of tailored practice and patient care plans with parallel qualitative, economic and policy analyses.
(BioMed Central Ltd., 2005-07-29)Background: The aim of the SPHERE study is to design, implement and evaluate tailored practice and personal care plans to improve the process of care and objective clinical outcomes for patients with established coronary ... -
Adenovirus-mediated and targeted expression of the sodium-iodide symporter permits in vivo radioiodide imaging and therapy of pancreatic tumors
(Mary Ann Liebert, 2006-06-15)Pancreatic cancer is the fourth leading cause of cancer death in the United States. It is highly aggressive with no uniformly effective chemotherapy available for metastatic disease. The sodium–iodide symporter (NIS) is a ... -
Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate
(2007)Recent physiological, pharmacological and anatomical studies provide evidence that one of the main roles of the endocannabinoid system in the brain is the regulation of ¿-aminobutyric acid (GABA) and glutamate release. ... -
Chronic fluoxetine treatment attenuates stressor-induced changes in temperature, heart rate, and neuronal activation in the olfactory bulbectomised rat
(2007)The olfactory bulbectomized (OB) rat is a well characterized animal model that exhibits a number of behavioural and neurochemical changes that have relevance to clinical depression. Hyperactivity in the open field is the ... -
Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia
(Bentham Science Publishers, 2007)The endogenous polyamines (spermine, spermidine, and putrescine) are present at relatively high concentrations in the mammalian brain and play crucial roles in a variety of aspects of cell functioning. Stroke is the third ... -
Responses to language barriers in consultations with refugees and asylum seekers: a telephone survey of Irish general practitioners
(BioMed Central, 2008)Background: Refugees and asylum seekers experience language barriers in general practice. Qualitative studies have found that responses to language barriers in general practice are ad hoc with use of both professional ... -
Effects of Gamma Irradiation and Pasteurization on the Nutritive Composition of Commercially Available Animal Diets
(2008)Gamma radiation is used to sterilize diets for specific pathogen-free (SPF) animals. Because a gamma-irradiated diet was linked to leukoencephalomyelopathy in SPF cats, we investigated the effects of 'typical' (28.9-34.3 ... -
Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
(Springer, 2008-06-04)Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic ... -
Endocannabinoid-mediated enhancement of fear-conditioned analgesia in rats: Opioid receptor dependency and molecular correlates
(International Association for the Study of Pain, 2008-12)The opioid and endocannabinoid systems mediate analgesia expressed upon re-exposure to a contextually aversive stimulus (fear-conditioned analgesia; FCA), and modulate the mitogen-activated protein kinase (MAPK) pathway. ... -
Chlamydia trachomatis infection and sexual behaviour among female students attending higher education in the Republic of Ireland
(2009)Background There are no prevalence data on Chlamydia trachomatis relating to female students attending higher education available for the Republic of Ireland. This information is required to guide on the necessity for ... -
Stress-induced analgesia.
(Butler, R. K. & Finn, D.P. (2009). Stress-induced analgesia. Progress in Neurobiology, 88, 184-202., 2009)For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have ... -
Comparison of the Glidescope® and Pentax AWS® laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation
(2009)Background Intubation of the trachea in the pre-hospital setting may be lifesaving in severely ill and injured patients. However, tracheal intubation is frequently difficult to perform in this challenging environment, is ... -
Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial.
(2009)Objective To test the effectiveness of a complex intervention designed, within a theoretical framework, to improve outcomes for patients with coronary heart disease. Design Cluster randomised controlled multicentre trial. ... -
Comparison of the Airtraq® and Truview® laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins
(2009)Background Paramedics are frequently required to perform tracheal intubation, a potentially life-saving manoeuvre in severely ill patients, in the prehospital setting. However, direct laryngoscopy is often more difficult ... -
6-iodonordihydrocapsaicin
(2009)6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated ... -
The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes
(2009)Background: Structured education programmes for individuals with Type 1 diabetes have become a recognised means of delivering the knowledge and skills necessary for optimal self-management of the condition. The Dose ...