Browsing School of Medicine by Title
Now showing items 87-106 of 336
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Distribution of tract deficits in schizophrenia
(BioMed Central, 2014-04-02)Background: Gray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric changes ... -
Disturbing effect of intra-tissue temperature sensors in pre-clinical experimental studies of radiofrequency cardiac ablation: A computer-based modeling study
(MDPI, 2023-04-11)Background: Preclinical studies on radiofrequency (RF) cardiac ablation (RFCA) use very small temperature sensors in specific positions in the tissue subjected to RF heating. Despite the sensors¿ small size, the proximity ... -
Do general practitioners prescribe more antimicrobials when the weekend comes?
(SpringerOpen, 2015-11-24)Inappropriate antimicrobial prescribing contributes to the global spread of antimicrobial resistance. The pending weekend with changed availability of general practitioners (GP) and increased patient concern may increase ... -
Does bridging therapy in mechanical thrombectomy increase recanalization rates in ischemic stroke patients affected by acute large vessel occlusion?
(SAGE Publications, 2019-05-22)Both intravenous thrombolysis with tissue plasminogen activator (IV-rtPA) and mechanical thrombectomy (MT) increase recanalization rates. We assessed if bridging-therapy (the concomitant use of rtPA and MT) could increase ... -
Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry
(Springer, 2021-08-20)Background and purpose There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT ... -
Don't blame it all on antibodies--The need for exhaustive characterisation, appropriate handling, and addressing the issues that affect specificity
(Elsevier, 2017-01-30)Recently there have been numerous very thought-provoking reports describing many issues relating to the overall quality of antibodies that are currently available. It appears that multiple major clinical and other analytical ... -
Dose-dependent effects of binge-like methamphetamine dosing on dopamine and neurotrophin levels in rat brain
(Karger Publishers, 2017-10-24)This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in ... -
Effect of a binge-like dosing regimen of methamphetamine on dopamine levels and tyrosine hydroxylase expressing neurons in the rat brain
(Elsevier, 2018-10-05)Methamphetamine, an amphetamine derivative, is a powerful psychomotor stimulant and commonly used drug of abuse. This study examined the effect of binge-like methamphetamine (MA) dosing (4 x 4 mg/kg, s.c., 2 h apart) on ... -
The effect of antidepressant medications in the management of heart failure on outcomes: mortality, cardiovascular function and depression - a systematic review
(Taylor & Francis, 2017-11-26)Depression is associated with increased morbidity, mortality and hospital readmission in patients with heart failure (HF). This systematic review aimed to compile studies examining whether the use of antidepressants could ... -
Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury
(Wiley, 2009-08-20)Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ... -
Effect of N1-Dansylspermine and Ro25,6981 on locomotor activity in naive mice and in the resperpinised mouse model of Parkinson's disease
(Lippincott, Williams & Wilkins, 2016-09-01)The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor ... -
The effect of operator position on the quality of chest compressions delivered in a simulated ambulance
(Cambridge University Press, 2019-12-09)Background: Ambulances are where patient care is often initiated or maintained, but this setting poses safety risks for paramedics. Paramedics have found that in order to optimize patient care, they must compromise their ... -
The effect of pain on cognitive function: a review of clinical and preclinical research.
(2011)Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical ... -
Effect of tailored practice and patient care plans on secondary prevention of heart disease in general practice: cluster randomised controlled trial.
(2009)Objective To test the effectiveness of a complex intervention designed, within a theoretical framework, to improve outcomes for patients with coronary heart disease. Design Cluster randomised controlled multicentre trial. ... -
Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder
(Nature Publishing Group, 2012)Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [O-15]-H2O ... -
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats
(Elsevier, 2003-07-31)The analgesic potential of cannabinoids may be hampered by their ability to produce aversive emotion when administered systemically. We investigated the hypothesis that the midbrain periaqueductal grey (PAG) is a common ... -
Effects of Gamma Irradiation and Pasteurization on the Nutritive Composition of Commercially Available Animal Diets
(2008)Gamma radiation is used to sterilize diets for specific pathogen-free (SPF) animals. Because a gamma-irradiated diet was linked to leukoencephalomyelopathy in SPF cats, we investigated the effects of 'typical' (28.9-34.3 ... -
The efficacy of mindfulness-based interventions in primary care: a meta-analytic review
(Annals of Family Medicine, 2015-07-16)PURPOSE Positive effects have been reported after mindfulness-based interventions (MBIs) in diverse clinical and nonclinical populations. Primary care is a key health care setting for addressing common chronic conditions, ... -
EIT image-based bladder state classification for nocturnal enuresis
(School of Engineering, The University of Edinburgh, 2018-06-11)In this paper, we propose the use of electrical impedance tomography (EIT) to support children with nocturnal enuresis. We perform the first image-based threshold classification for determining the bladder state of not ... -
The emerging spectrum of fetal acetylcholine receptor antibody-related disorders (FARAD)
(Oxford University Press, 2023-05-15)In utero exposure to maternal antibodies targeting the fetal acetylcholine receptor isoform (fAChR) can impair fetal movement, leading to arthrogryposis multiplex congenita (AMC). Fetal AChR antibodies have also been ...