Browsing School of Medicine by Title

Now showing items 203-222 of 336

    • Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation 

      Murphy, Nick; Lynch, Kevin; Lohan, Paul; Treacy, Oliver; Ritter, Thomas (Lippincott, Williams & Wilkins, 2016-12)
      PURPOSE OF REVIEW: This article reviews the literature on the therapeutic potential of mesenchymal stem cells (MSCs) to prolong corneal allograft survival. RECENT FINDINGS: To date, only small numbers studies have ...

    • Mesenchymal stem cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer 

      Dwyer, Róisín M.; Ryan, James; Havelin, Ronan J.; Morris, John C.; Miller, Brian W.; Liu, Zhonglin; Flavin, Richard; O'Flatharta, Cathal; Foley, Mark J.; Barrett, Harrison H; Murphy, J. Mary; Barry, Frank P; O'Brien, Timothy; Kerin, Michael J. (AlphaMed Press, 2011-05-23)
      Mesenchymal Stem Cells (MSCs) migrate specifically to tumors in vivo, and coupled with their capacity to bypass immune surveillance, are attractive vehicles for tumor-targeted delivery of therapeutic agents. This study ...

    • Mesenchymal Stem Cells (MSCs) and cancer: tumour specific delivery vehicles or therapeutic targets? 

      Dwyer, Róisín M.; Kerin, Michael J. (Mary Ann Liebert, 2010-09-30)
      Mesenchymal stem cells (MSCs) are a subset of nonhematopoietic multipotent cells found primarily within the bone marrow stroma. The ability of MSCs to specifically home to sites of tumors and their metastases, while escaping ...

    • Mesenchymal stem cells in the colorectal tumor microenvironment: Recent progress and implications 

      Hogan, Niamh M.; Dwyer, Róisín M.; Joyce, Myles R.; Kerin, Michael J. (Wiley, 2012-01-30)
      Mesenchymal stem cells (MSCs) are nonhematopoietic multipotent adult stem cells. They have been shown to have a natural tropism for many tumors types, including colorectal, and are capable of escaping host immune surveillance. ...

    • A meta-analysis of the effectiveness of crew resource management training in acute care domains. 

      O'Dea, Angela; O'Connor, Paul; Keogh, Ivan (2014)
      The healthcare industry has seen an increase in the adoption of team training, such as crew resource management (CRM), to improve teamwork and coordination within acute care medical teams. A meta-analysis was carried out ...

    • MicroRNA expression in colorectal cancer. 

      Hogan, Niamh M.; Joyce, Myles R. (IOS Press, 2012-12-17)
      Colorectal cancer is a common disease entity with a multi-factorial aetiology which remains poorly understood. It is estimated that in 2008, colorectal cancerwas responsible for 8% of all cancer deaths, making it the fourth ...

    • MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer 

      Chang, Kah Hoong; Mestdagh, Pieter; Vandesompele, Jo; Kerin, Michael J.; Miller, Nicola (Biomed Central, 2010)
      Background Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription ...

    • Minimum information about T Regulatory Cells: A step toward reproducibility and standardization 

      Fuchs, Anke; Gliwinski, Mateusz; Grageda, Nathali; Spiering, Rachel; Abbas, Abul K.; Appel, Silke; Bacchetta, Rosa; Battaglia, Manuela; Berglund, David; Blazar, Bruce; Bluestone, Jeffrey A.; Bornhaeuser, Martin; ten Brinke, Anja; Brusko, Todd M.; Cools, Nathalie; Cuturi, Maria Cristina; Geissler, Edward; Giannoukakis, Nick; Golab, Karolina; Hafler, David A.; van Ham, S. Marieke; Hester, Joanna; Hippen, Keli; Di Ianni, Mauro; Ilic, Natasa; Isaacs, John; Issa, Fadi; Iwaszkiewicz-Grzes, Dorota; Jaeckel, Elmar; Joosten, Irma; Klatzmann, David; Koenen, Hans; van Kooten, Cees; Korsgren, Olle; Kretschmer, Karsten; Levings, Megan; Marek-Trzonkowska, Natalia Maria; Martinez-Llordella, Marc; Miljkovic, Djordje; Mills, Kingston H. G.; Miranda, Joana P.; Piccirillo, Ciriaco A.; Putnam, Amy L.; Ritter, Thomas; Roncarolo, Maria Grazia; Sakaguchi, Shimon; Sanchez-Ramon, Silvia; Sawitzki, Birgit; Sofronic-Milosavljevic, Ljiljana; Sykes, Megan; Tang, Qizhi; Vives-Pi, Marta; Waldmann, Herman; Witkowski, Piotr; Wood, Kathryn J.; Gregori, Silvia; Hilkens, Catharien M. U.; Lombardi, Giovanna; Lord, Phillip; Martinez-Caceres, Eva M.; Trzonkowski, Piotr (Frontiers Media, 2018-01-15)
      Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing ...

    • Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies 

      Lord, Philip; Spiering, Rachel; Aguillon, Juan C.; Anderson, Amy E.; Appel, Silke; Benitez-Ribas, Daniel; ten Brinke, Anja; Broere, Femke; Cools, Nathalie; Cuturi, María Cristina; Diboll, Julie; Geissler, Edward; Giannoukakis, Nick; Gregori, Silvia; van Ham, Sija Marieke; Lattimer, Staci; Marshall, Lindsay F.; Harry, Rachel A.; Hutchinson, James A.; Isaacs, John D.; Joosten, Irma; van Kooten, Cees; de Cerio, Ascensión López Díaz; Nikolic, Tatjana; Oral, Haluk Barbaros; Sofronic-Milosavljevic, Ljiljana; Ritter, Thomas; Riquelme, Paloma; Thomson, Angus W.; Trucco, Massimo; Vives-Pi, Marta; Martinez-Caceres, Eva M.; Hilkens, Catharien M.U. (PeerJ, 2016-08-30)
      Cellular therapies, with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation The methodologies ...

    • Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression 

      Burke, Nikita N.; Kerr, Daniel M.; Moriarty, Orla; Finn, David P.; Roche, Martin (Elsevier, 2014-11)
      There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ...

    • miR-379 Regulates Cyclin B1 Expression and Is Decreased in Breast Cancer 

      Khan, Sonja; Brougham, Cathy L.; Ryan, James; Sahrudin, Arisha; O'Neill, Gregory; Wall, Deirdre; Curran, Catherine; Newell, John; Kerin, Michael J.; Dwyer, Róisín M. (2013)
      MicroRNAs are small non-coding RNA molecules that control gene expression post-transcriptionally, and are known to be altered in many diseases including breast cancer. The aim of this study was to determine the relevance ...

    • A mixed method, multiperspective evaluation of a near peer teaching programme 

      Lydon, Sinéad; O'Connor, Paul; Mongan, Orla; Gorecka, Miroslawa; McVicker, Lyle; Stankard, Aiden; Byrne, Dara (BMJ Publishing Group, 2017-02-24)
      Purpose of study Peer teaching (PT) has become increasingly popular. PT may offer benefits for students, tutors and institutions. Although resistance to PT has been identified among faculty, research has typically focused ...

    • A mixed methods evaluation of paediatric trainee preparedness to manage cardiopulmonary arrests 

      Walsh, Órla; Lydon, Sinéad; O'Connor, Paul (Springer, 2017-09-21)
      Paediatric cardiopulmonary arrest (CPA) survival rates are strongly linked to the training of the doctors responding to the event. This study sought to characterise the level of experience in managing CPAs among paediatric ...

    • A mixed-methods examination of the nature and frequency of medical error among junior doctors 

      O'Connor, Paul; Lydon, Sinéad; Mongan, Orla; Connolly, Fergal; McLoughlin, Aoibheann; McVicker, Lyle; Byrne, Dara (BMJ Publishing Group, 2019-07-24)
      Abstract Purpose of the study To examine junior doctors’ experience and perceptions of medical errors in which they had been involved. Study design A mixed-methods design, consisting of an error survey and critical ...

    • A mixed-methods exploration of the educational climate and safety climate during the first year of clinical practice in Ireland 

      Lydon, Sinéad; Byrne, Dara; Vellinga, Akke; Walsh, Chloe; Madden, Caoimhe; Connolly, Fergal; O'Connor, Paul (Lippincott, Williams & Wilkins, 2019-11)
      Purpose Educational climate (EC) and safety climate (SC) are key determinants of residents’ professional development. The goal of this study was to gather longitudinal EC data and data on perceptions of SC in residency, ...

    • A mixed-methods investigation of health professionals' perceptions of a physiological track and trigger system 

      Lydon, Sinéad; Byrne, Dara; Offiah, Gozie; Gleeson, Louise; O'Connor, Paul (BMJ Publishing Group, 2015-10-09)
      Background Physiological track and trigger systems (PTTSs) regulate the monitoring of patients vital signs and facilitate the detection and treatment of deteriorating patients. These systems are widely used although ...

    • A mixed-methods study of the causes and impact of poor teamwork between junior doctors and nurses 

      O'Connor, Paul; O'Dea, Angela; Lydon, Sinéad; Offiah, Gozie; Scott, Jennifer; Flannery, Antoinette; Lang, Bronagh; Hoban, Anthony; Armstrong, Catherine; Byrne, Dara (Oxford University Press (OUP), 2016-07-02)
      Objectives This study aimed to collect and analyse examples of poor teamwork between junior doctors and nurses; identify the teamwork failures contributing to poor team function; and ascertain if particular teamwork ...

    • Modern management of pyogenic hepatic abscess: a case series and review of the literature 

      Heneghan, Helen M.; Healy, Nuala A. (BioMed Central, 2011-03)
      Background Pyogenic hepatic abscesses are relatively rare, though untreated are uniformly fatal. A recent paradigm shift in the management of liver abscesses, facilitated by advances in diagnostic and interventional ...

    • Modulation of Conditioned Fear, Fear-Conditioned Analgesia, and Brain Regional C-Fos Expression Following Administration of Muscimol into the Rat Basolateral Amygdala 

      Rea, Kieran; Roche, Michelle; Finn, David P. (Elsevier, 2011-04)
      Evidence suggests that gamma-aminobutyric acid (GABA) signalling in the basolateral amygdala (BLA) is involved in pain, fear, and fear-conditioned analgesia (FCA). In this study, we investigated the effects of intra-BLA ...

    • Modulation of stress by imidazoline binding sites: Implications for psychiatric disorders 

      Smith, Karen L.; Jessop, David S.; Finn, David P. (Taylor & Francis, 2009-07-07)
      In this review, we present evidence for the involvement of imidazoline binding sites (IBS) in modulating responses to stress, through central control of monoaminergic and hypothalamo-pituitary-adrenal (HPA) axis activity. ...