Browsing School of Medicine by Title
Now showing items 152-171 of 284
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Intervention to improve the quality of antimicrobial prescribing for urinary tract infection: a cluster randomized trial
(Canadian Medical Association, 2015-11-16)Background: Overuse of antimicrobial therapy in the community adds to the global spread of antimicrobial resistance, which is jeopardizing the treatment of common infections.Methods: We designed a cluster randomized complex ... -
Interventions to improve hand hygiene compliance in the ICU: A systematic review
(Lippincott, Williams & Wilkins, 2017-11)Objectives: To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. Data ... -
Investigating the management of diabetes in nursing homes using a mixed methods approach
(Elsevier ScienceDirect, 2017-03-21)Aims: As populations age there is an increased demand for nursing home (NH) care and a parallel increase in the prevalence of diabetes. Despite this, there is growing evidence that the management of diabetes in NHs is ... -
Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats
(Wiley, 2014-11-15)BackgroundDistraction is used clinically to relieve and manage pain. It is hypothesized that pain demands attention and that exposure to another attention-demanding stimulus causes withdrawal of attention away from painful ... -
The Irish DAFNE Study Protocol: A cluster randomised trial of group versus individual follow-up after structured education for Type 1 diabetes
(2009)Background: Structured education programmes for individuals with Type 1 diabetes have become a recognised means of delivering the knowledge and skills necessary for optimal self-management of the condition. The Dose ... -
Irish policy-makers' perceptions of barriers and facilitators to hand hygiene compliance
(Irish Medical Organisation, 2019-04)Introduction Despite its’ role in infection prevention, hand hygiene (HH) compliance rates in healthcare settings remain sub-optimal. Little research has examined policy-makers’ perceptions of contributory barriers and ... -
Is diabetes self-management education still the Cinderella of diabetes care?
(Elsevier ScienceDirect, 2017-05-17)This paper reflects on the status of diabetes self-management education (DSME) as a branch of diabetology in Europe and discusses some opportunities for better supporting DSME delivery. DSME (also commonly known as Therapeutic ... -
Isolation of secreted microRNAs (miRNAs) from cell-conditioned media
(2013)MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ... -
The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer
(2012)Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ... -
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
(Nature Publishing Group (Macmillan), 2013-03-27)Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ... -
Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord
(Elsevier, 2012-01-08)Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ... -
Lentiviral vector‐mediated knockdown of the neuroglycan 2 proteoglycan or expression of neurotrophin‐3 promotes neurite outgrowth in a cell culture model of the glial scar
(Wiley, 2010)Background Following spinal cord injury, a highly inhibitory environment for axonal regeneration develops. One of the main sources of this inhibition is the glial scar that is formed after injury by reactive astrocytes. ... -
Linguistic and Psychometric Validation of the Diabetes-Specific Quality-of-Life Scale in UK English for Adults With Type 1 Diabetes
(American Diabetes Association, 2012-12-18)OBJECTIVE-To develop a linguistically and psychometrically validated U.K. English (U.K.! Ireland) version of the Diabetes-Specific Quality-of-Life Scale (DSQOLS) for adults with type 1 diabetes.RESEARCH DESIGN AND METHODS-We ... -
Lipid lowering therapy, low-density lipoprotein level and risk of intracerebral hemorrhage – a meta-analysis
(Elsevier, 2019-03-14)The association of lipid lowering therapy and intracerebral hemorrhage risk is controversial. We performed a cumulative meta-analysis of lipid lowering trials that reported intracerebral hemorrhage. Statin, fibrate, ... -
Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats
(Elsevier, 2018-12-13)Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial mu-opioid receptor (MOR) agonist and ... -
A longitudinal qualitative study examining the factors impacting on the ability of persons with T1DM to assimilate the Dose Adjustment For Normal Eating (DAFNE) principles into daily living and how these factors change over time
(BioMed Central, 2011-08-30)The literature reveals that structured education programmes, such as DAFNE, result in many positive outcomes for people with Type 1 diabetes including a decrease in HbA1c levels and reductions in hypoglycaemia. While there ... -
The management of diabetes in adults and children with psychiatric disorders in inpatient settings
(JBDS-IP (Joint British Diabetes Societies for Inpatient Care) and RCPsych (Royal College of Psychiatrists), 2017-05)Nearly every category of ICD-10 Chapter F (mental disorders) is associated with diabetes and with worse outcomes and premature mortality.1 In addition, many people with diabetes suffer from diabetes related distress. The ... -
The maternal and fetal impacts of obesity and gestational diabetes on pregnancy outcome
(2010)Obesity has reached pandemic proportions and is of growing concern worldwide. Adverse health outcomes associated with a raised body mass index present the greatest challenge currently facing clinicians across all ... -
Maternal deprivation is associated with sex-dependent alterations in nociceptive behavior and neuroinflammatory mediators in the rat following peripheral nerve injury
(Elsevier, 2013-10)Early-life stress is associated with an increased risk of developing affective disorders and chronic pain conditions. This study examined the effect of maternal deprivation (MD) on nociceptive responding prior to and ... -
Medical speciality choices: Does personality matter?
(Irish Medical Journal, 2015-08-07)There has been increasing interest in the personalities of doctors. This study examined whether personality differed based upon gender, level of training or medical speciality among 200 physicians and 134 medical students. ...