Browsing School of Medicine by Title
Now showing items 319-336 of 336
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Teaching and learning through civic engagement: prospects for sustainability in teacher education
(2010)This paper considers the prospects for sustainable service/community based learning as an element of a civic engagement strategy within the context of teacher education. It draws on findings of a study of the policy, ... -
Therapeutic effect of neurotrophin-3 treatment in an injectable collagen scaffold following rat spinal cord hemisection injury
(American Chemical Society, 2016-08-01)Spinal cord injury (SCI) patients display varying quantities of spinal cord tissue damage with injuries that present as complete, incomplete or compressive. One theory proposed to repair the injured spinal cord and regain ... -
These shoes are made for walking: sensitivity performance evaluation of commercial activity monitors under the expected conditions and circumstances required to achieve the international daily step goal of 10,000 steps
(Public Library of Science, 2016-05-11)IntroductionPhysical activity is a vitally important part of a healthy lifestyle, and is of major benefit to both physical and mental health. A daily step count of 10,000 steps is recommended globally to achieve an appropriate ... -
Third-party allogeneic mesenchymal stromal cells prevent rejection in a pre-sensitized high-risk model of corneal transplantation
(Frontiers Media, 2018-11-20)High-risk cornea transplant recipients represent a patient population with significant un-met medical need for more effective therapies to prevent immunological graft rejection due to heightened anti-donor immune response. ... -
Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure
(Elsevier, 2019-11-03)Methamphetamine (MA), a synthetic derivate of amphetamine, has become a major drug of abuse worldwide. This study investigated the effect of binge-like MA dosing (4 x 4 mg/kg, s.c., 2 h (h) apart) at a range of different ... -
TNF-a/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung.
(Federation of American Society of Experimental Biology (FASEB), 2019-05-20)Mesenchymal stromal cells (MSCs) have shown promise as a therapy for immune-mediated disorders, including transplant rejection. Our group previously demonstrated the efficacy of pretransplant, systemic administration of ... -
A toolkit for improving hand hygiene compliance in intensive care
(National University of Ireland Galway, 2020-10-15)A toolkit to help intensive care units to identify how they can improve hand hygiene compliance. -
Ulk4 regulates GABAergic signaling and anxiety-related behavior
(Springer Nature, 2018-02-02)Excitation/inhibition imbalance has been proposed as a fundamental mechanism in the pathogenesis of neuropsychiatric and neurodevelopmental disorders, in which copy number variations of the Unc-51 like kinase 4 (ULK4) gene ... -
Urinary sodium and potassium, and risk of ischemic and hemorrhagic stroke (INTERSTROKE): A case–control study
(Oxford University Press, 2020-11-16)Although low sodium intake (3·5g/day) are proposed as public health interventions to reduce stroke risk, there is uncertainty about the benefit and feasibility of this combined recommendation on prevention of stroke and ... -
Using mobile phones to collect patient data: lessons learned from the SIMPle study
(JMIR Publications, 2017-04-25)Background: Mobile phones offer new opportunities to efficiently and interactively collect real-time data from patients with acute illnesses, such as urinary tract infections (UTIs). One of the main benefits of using mobile ... -
Using qualitative insights to change practice: exploring the culture of antibiotic prescribing and consumption for urinary tract infections
(BMJ Publishing Group, 2016-01-11)Objectives: The aim of this paper is to explore the culture of antibiotic prescribing and consumption in the community for urinary tract infections (UTI) from the perspective of the general practitioners (GPs) and community ... -
Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain
(2012)Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance ... -
Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain
(Elsevier, 2011-11)Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance ... -
The very first requirement of treatment is that it should do no harm†, so why are antibiotics still overprescribed?
(Wiley, 2014-01-26)[No abstract available] -
vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis
(2016-05-18)Recent efforts in osteoarthritis (OA) research have highlighted synovial inflammation and involvement of immune cells in disease onset and progression. We sought to establish the in-vivo immune response in collagenase-induced ... -
WestREN: a description of an Irish academic general practice research network
(BioMed Central, 2010-10)Background:Primary care research networks have been established internationally since the 1960s to enable diverse practitioners to engage in and develop research and education and implement research evidence. The newly ... -
When a step is not a step! Specificity analysis of five physical activity monitors
(Public Library of Science, 2017-01-13)IntroductionPhysical activity is an essential aspect of a healthy lifestyle for both physical and mental health states. As step count is one of the most utilized measures for quantifying physical activity it is important ...