Browsing School of Medicine by Title
Now showing items 11-30 of 336
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Adverse events of fluoroquinolones vs. other antimicrobials prescribed in primary care: A systematic review and meta-analysis of randomized controlled trials
(Elsevier, 2018-04-25)Background Fluoroquinolones (FQs) are second line antimicrobial agents. Once the decision to prescribe an antimicrobial is made, its choice should be based on both the benefits and harms. This systematic review quantifies ... -
Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat
(Elsevier, 2019-12-13)Introduction: Stress is a major component of many animal models of depression, induced acutely as in the forced swim test, or more long-term in the olfactory bulbectomy (OB) and chronic mild stress models [1]. The central ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
(Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Am I being watched? The role of researcher presence on toddlers’ behaviour during ‘everyday’ pain experiences: a pilot study
(Taylor & Francis, 2019-12-31)Objective: Paediatric research on 'everyday' pain experiences is sparse, stemming from a lack of appropriate methodologies. We explored the feasibility of two methodologies for conducting naturalistic observations of ... -
Analysing complaints about primary care with the healthcare complaints analysis tool (General Practice): A user’s guide
(National University of Ireland Galway, 2022-01)General practice is a vital aspect of the health service, with large numbers of patient contacts every year1. While general practice is often seen as inherently less risky than secondary care2, errors have been found to ... -
An analysis of general practitioners’ perspectives on patient safety incidents using critical incident technique interviews
(Oxford University Press (OUP), 2019-03-30)Background General practitioners report difficulty in knowing how to improve patient safety. Objectives To analyse general practitioners’ perspectives of contributing factors to patient safety incidents by collecting ... -
Analysis of reactive astrocytes and NG2 proteoglycan in ex vivo rat models of spinal cord injury
(Elsevier, 2018-09-26)Background: The use of animals to model spinal cord injury (SCI) requires extensive post-operative care and can be expensive, which makes an altemative model extremely attractive. The use ofex vivo slice cultures is an ... -
Analysis of thermal effects from pulsed field ablation
(Oxford University Press, 2023-11-09)Background Pulsed field ablation (PFA) has been described as non-thermal, but abundant data exist in oncology applications [1-3], and growing data are emerging in cardiology [4], highlighting that thermal effects are in ... -
Anandamide modulation of endotoxin-induced inflammation
(OMICS International, 2013-12-20)The endocannabinoid system is comprised of the CB1 and CB2 receptors, the naturally occurring endogenous ligands, anandamide (AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes involved in their synthesis and ... -
Animal models of focal cerebral ischaemia and haemorrhage transformation: considerations in experimental stroke study design
(Bentham Science Publishers, 2017)Background: Ischaemic stroke is often complicated with haemorrhage within the infarct zone or in a remote location especially when treated with intravenous thrombolysis and/or thrombectomy. While these early recanalisation ... -
Anti-donor immune responses elicited by allogeneic mesenchymal stem cells and their extracellular vesicles: Are we still learning?
(Frontiers Media, 2017-11-24)Mesenchymal stromal cells (MSC) have been used to treat a broad range of disease indications such as acute and chronic inflammatory disorders, autoimmune diseases, and transplant rejection due to their potent immunosuppr ... -
Antimicrobial management and appropriateness of treatment of urinary tract infection in general practice in Ireland
(2011)ABSTRACT: BACKGROUND: Urinary tract infections (UTIs) are the second most common bacterial infections in general practice and a frequent indication for prescription of antimicrobials. Increasing concern about the association ... -
Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex
(Elsevier, 2020-07-13)The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ... -
The application of human reliability analysis to three critical care procedures
(Elsevier, 2020-07-10)Background: Procedures carried out in the intensive care unit are prone to human error. Standardisation has been suggested as an approach for reducing errors. This study used human reliability analysis methodologies to ... -
Application of video-based methods for competitive swimming analysis: a systematic review
(2015)This paper explores the application of video-based methods for the analysis of com- petitive swimming performance. A systematic search of the existing literature was conducted using the following keywords: swim*, performance, ... -
Artificial cornea: Past, current, and future directions
(Frontiers Media, 2021-11-12)Corneal diseases are a leading cause of blindness with an estimated 10 million patients diagnosed with bilateral corneal blindness worldwide. Corneal transplantation is highly successful in low-risk patients with corneal ... -
ASPiH Conference 2019 keynote paper. Quality improvement through simulation: a missed opportunity?
(BMJ Publishing Group, 2020-03-04)As the use of simulation has become more established in the delivery of healthcare education and training, there has been a corresponding increase in healthcare simulation research. Simulation-based research can be divided ... -
Assembly of protein-based hollow spheres encapsulating a therapeutic factor
(American Chemical Society, 2013-06-13)Neurotrophins, as important regulators of neural development, function and survival, have a therapeutic potential to repair damaged neurons. However, a controlled delivery of therapeutic molecules to injured tissue remains ... -
The association of white matter volume in psychotic disorders with genotypic variation in NRG1, MOG and CNP: a voxel-based analysis in affected individuals and their unaffected relatives
(Nature Publishing Group, 2012)We investigated the role of variation in putative psychosis genes coding for elements of the white matter system by examining the contribution of genotypic variation in three single-nucleotide polymorphisms (SNPs) neuregulin ... -
Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies
(Elsevier, 2016-05-20)Background Several studies reported a U-shaped association between urinary sodium excretion and cardiovascular disease events and mortality. Whether these associations vary between those individuals with and without ...