Browsing College of Medicine, Nursing and Health Sciences by Author "Kerr, Daniel M."
Now showing items 1-14 of 14
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Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
Burke, Nikita N.; Geoghegan, E.; Moriarty, Orla; Finn, David P.; Kerr, Daniel M.; Roche, Michelle (Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Anandamide modulation of endotoxin-induced inflammation
Kerr, Daniel M.; Henry, Rebecca; Roche, Michelle (OMICS International, 2013-12-20)The endocannabinoid system is comprised of the CB1 and CB2 receptors, the naturally occurring endogenous ligands, anandamide (AEA) and 2-arachidonyl glycerol (2-AG); and the enzymes involved in their synthesis and ... -
Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways
Dyall, S. C.; Dyall, Simon C.; Mandhair, Harpreet K.; Fincham, R. E. A.; Kerr, Daniel M.; Roche, Michelle; Molina-Holgado, Francisco (Elsevier, 2016-04-01)Emerging evidence suggests a complex interplay between the endocannabinoid system, omega-3 fatty acids and the immune system in the promotion of brain self-repair. However, it is unknown if all omega 3 fatty acids elicit ... -
Endocannabinoid modulation of inflammatory hyperalgesia in the IFN-α mouse model of depression
Fitzgibbon, Marie; Kerr, Daniel M.; Henry, Rebecca J.; Finn, David P.; Roche, Michelle (Elsevier, 2019-09-07)Depression is a well-recognised effect of long-term treatment with interferon-alpha (IFN-alpha), a widely used treatment for chronic viral hepatitis and malignancy. In addition to the emotional disturbances, high incidences ... -
Evidence for a role of GABAergic and glutamatergic signalling in the basolateral amygdala in endocannabinoid-mediated fear-conditioned analgesia in rats
Rea, Kieran; Olango, Weredeselam M.; Harhen, Brendan; Kerr, Daniel M.; Galligan, Rachel; Fitzgerald, Sean; Moore, Maeve; Roche, Michelle; Finn, David P. (Elsevier, 2012-12-31)The basolateral amygdala (BLA) is a key substrate facilitating the expression of fear-conditioned analgesia (FCA). However, the neurochemical mechanisms in the BLA which mediate this potent suppression of pain responding ... -
Exacerbated LPS/GalN-induced liver injury in the stress-sensitive Wistar Kyoto rat is associated with changes in the endocannabinoid system
Killilea, Marykate; Kerr, Daniel M.; Mallard, Beth M.; Roche, Michelle; Wheatley, Antony M. (MDPI, 2020-08-23)Acute liver injury (ALI) is a highly destructive and potentially life-threatening condition, exacerbated by physical and psychological stress. The endocannabinoid system plays a key role in modulating stress and hepatic ... -
FAAH inhibition attenuates TLR3-mediated hyperthermia, nociceptive- and anxiety-like behaviour in female rats
Flannery, Lisa E.; Kerr, Daniel M.; Finn, David P.; Roche, Michelle (Elsevier, 2018-06-25)Aberrant activation of toll-like receptor (TLR)s results in persistent and prolonged neuroinflammation and has been implicated in the pathogenesis and exacerbation of psychiatric and neurodegenerative disorders. TLR3 ... -
FAAH, but not MAGL, inhibition modulates acute TLR3‐induced neuroimmune signaling in the rat, independent of sex
Flannery, Lisa E.; Henry, Rebecca J.; Kerr, Daniel M.; Finn, David P.; Roche, Michelle (Wiley, 2017-07-20)Toll-like receptor (TLR)3 is a key component of the innate immune response to viral infection. The present study firstly examined whether sex differences exist in TLR3-induced inflammatory, endocrine, and sickness responses. ... -
For whom the endocannabinoid tolls: Modulation of innate immune function and implications for psychiatric disorders
Henry, Rebecca J.; Kerr, Daniel M.; Finn, David P.; Roche, Michelle (Elsevier, 2015-03-17)Toll-like receptors (TLRs) mediate the innate immune response to pathogens and are critical in the host defence, homeostasis and response to injury. However, uncontrolled and aberrant TLR activation can elicit potent effects ... -
Kappa opioid receptor-mediated modulation of social responding in adolescent rats and in rats prenatally exposed to valproic acid
Hughes, Edel M.; Thornton, Aoife M.; Kerr, Daniel M.; Smith, Karen; Sanchez, Connie; Kelly, John P.; Finn, David P. (Elsevier, 2020-08-05)The kappa opioid receptor (KOP) system modulates social play responding, however a paucity of studies have examined effects on social motivation and cognition in the absence of play. Prenatal exposure to the anti epileptic ... -
Maternal presence or absence alters nociceptive responding and cortical anandamide levels in juvenile female rats
O’Sullivan, Grace; Humphrey, Rachel M.; Thornton, Aoife M.; Kerr, Daniel M.; McGuire, Brian E.; Caes, Line; Roche, Michelle (Elsevier, 2020-05-30)The influence of parental support on child pain experiences is well recognised. Accordingly, animal studies have revealed both short- and long-term effects of early life stress on nociceptive responding and neural substrates ... -
Minocycline modulates neuropathic pain behaviour and cortical M1-M2 microglial gene expression in a rat model of depression
Burke, Nikita N.; Kerr, Daniel M.; Moriarty, Orla; Finn, David P.; Roche, Martin (Elsevier, 2014-11)There is a paucity of data on the role of microglia and neuroinflammatory processes in the association between chronic pain and depression. The current study examined the effect of the microglial inhibitor minocycline on ... -
Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
Henry, Rebecca J.; Kerr, Daniel M.; Flannery, Lisa E.; Killilea, Marykate; Hughes, Edel M.; Corcoran, Louise; Finn, David P.; Roche, Michelle (Elsevier, 2017-02-22)Aberrant activation of toll-like receptors (TLRs), key components of the innate immune system, has been proposed to underlie and exacerbate a range of central nervous system disorders. Increasing evidence supports a role ... -
Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid
Kerr, Daniel M.; Gilmartin, Aoife; Roche, Michelle (Elsevier, 2016-08-31)Autism spectrum disorders are a group of neurodevelopmental disorders characterised by impaired social interaction, deficits in communication and repetitive stereotyped behaviours. The endocannabinoid system plays an ...