Browsing College of Medicine, Nursing and Health Sciences by Author "Finn, David P."
Now showing items 1-20 of 70
-
6-iodonordihydrocapsaicin
Roche, Michelle; Finn, David P. (2009)6-Iodonordihydrocapsaicin was first synthesized by Giovanni Appendino at the Department of Chemical, Food, Pharmaceutical and Pharmacological Sciences (DiSCAFF), Novara, Italy, while developing a series of halogenated ... -
Alterations in the central opioid system following acute swim stress and olfactory bulbectomy in the rat
McHugh, K.; P.Calcagno, P.; Calcagno, P.; Ferdousi, M.; Sanchez, C.; Roche, Michelle; Finn, David P.; Kelly, John P. (Elsevier, 2019-12-13)Introduction: Stress is a major component of many animal models of depression, induced acutely as in the forced swim test, or more long-term in the olfactory bulbectomy (OB) and chronic mild stress models [1]. The central ... -
Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala
Burke, Nikita N.; Geoghegan, E.; Moriarty, Orla; Finn, David P.; Kerr, Daniel M.; Roche, Michelle (Wiley, 2013-08-29)The association between chronic pain and depression is widely recognized, the comorbidity of which leads to a heavier disease burden, increased disability and poor treatment response. This study examined nociceptive ... -
Antinociceptive effects of the GPR55 Antagonist CID16020046 injected into the rat anterior cingulate cortex
Okine, Bright N.; Mc Laughlin, Gemma; Gaspar, Jessica C.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2020-07-13)The G-protein coupled receptor, GPR55, modulates nociceptive processing. Given the expression of GPR55 in the anterior cingulate cortex (ACC), a key brain region involved in the cognitive and affective dimensions of pain, ... -
Attenuation of fear‐conditioned analgesia in rats by monoacylglycerol lipase inhibition in the anterior cingulate cortex: Potential role for CB2 receptors
Corcoran, Louise; Mattimoe, Darragh; Roche, Michelle; Finn, David P. (The British Pharmacological Society, 2020-01-22)Improved understanding of brain mechanisms regulating endogenous analgesia is important from a fundamental physiological perspective and for identification of novel therapeutic strategies for pain. The endocannabinoid ... -
Behavioural, neurochemical and neuroendocrine effects of the endogenous beta-carboline harmane in fear-conditioned rats
Smith, Karen L.; Ford, Gemma K.; Finn, David P. (2012)The putative endogenous imidazoline binding site ligand harmane enhances neuronal activation in response to psychological stress and alters behaviour in animal models of anxiety and antidepressant efficacy. However, the ... -
Brain CB2 receptors: Implication for Neuropsychiatric disorders
Roche, Michelle; Finn, David P. (2010)Although previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression ... -
Cannabinoids and pain: sites and mechanisms of action
Starowicz, Katarzyna; Finn, David P. (Elsevier, 2017-06-20)The endocannabinoid system, consisting of the cannabinoid(1) receptor (CB1R) and cannabinoid(2) receptor (CB2R), endogenous cannabinoid ligands (endocannabinoids), and metabolizing enzymes, is present throughout the pain ... -
Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
Okine, Bright N.; Gaspar, Jessica C.; Madasu, Manish K.; Olango, Weredeselam M.; Harhen, Brendan; Roche, Michelle; Finn, David P. (Elsevier, 2016-12-01)The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling ... -
Characterization of the affective component of acute postoperative pain associated with a novel rat model of inguinal hernia repair pain
Bree, Dara; Moriarty, Orla; Broom, Daniel C.; Kelly, John P.; Roche, Michelle; Finn, David P. (Wiley, 2015-12-10)Aims: Acute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on evoked withdrawal or reflexive measures. Using a recently developed, ... -
Chronic administration of amitriptyline differentially alters neuropathic pain-related behaviour in the presence and absence of a depressive-like phenotype
Burke, Nikita N.; Finn, David P.; Roche, Michelle (Elsevier, 2015-02)Chronic pain and depression share a complex, reciprocal relationship. Furthermore, in addition to treating depression, antidepressants such as amitriptyline are a first-line treatment for chronic pain conditions, indicating ... -
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
Burke, Nikita N.; Li, Yan; Daniel R Deaver, Daniel R.; Deaver, Daniel R.; Finn, David P.; Roche, Michelle; Eyerman, David J.; Sanchez, Connie; Kelly, John P. (SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Clinical correlates of stress-induced analgesia: evidence from pharmacological studies
Ford, Gemma K.; Finn, David P. (Elsevier, 2008) -
Cognition and pain
Moriarty, Orla; Finn, David P. (Lippincott, Williams & Wilkins, 2014-06)Purpose of reviewPain and cognition share common neural substrates and are known to interact reciprocally. This has implications for treatment and management of pain conditions; pain can negatively affect cognitive ... -
Cognitive impairment in patients with chronic neuropathic or radicular pain: An interaction of pain and age
Moriarty, Orla; Ruane, Nancy; O'Gorman, David; Maharaj, Chris H.; Mitchell, Caroline; Sarma, Kiran M.; Finn, David P.; McGuire, Brian E. (Frontiers Media, 2017-06-13)A growing body of empirical research has confirmed an association between chronic pain and cognitive dysfunction. The aim of the present study was to determine whether cognitive function is affected in patients with a ... -
Development and characterization of a novel, anatomically relevant rat model of acute postoperative pain
Bree, Dara; Moriarty, Orla; O’Mahony, Cliona M.; Morris, Bradley; Bannerton, Karen; Broom, Daniel C.; Kelly, John P.; Roche, Michelle; Finn, David P. (Elsevier, 2015-01-30)Acute postoperative pain remains a significant health care issue. Development of anatomically relevant animal models of postoperative pain, with improved predictive validity, would advance understanding of postoperative ... -
The development of translational biomarkers as a tool for improving the understanding, diagnosis and treatment of chronic neuropathic pain
Buckley, David A.; Jennings, Elaine M.; Burke, Nikita N.; Roche, Michelle; McInerney, Veronica; Wren, Jonathan D.; Finn, David P.; McHugh, Patrick C. (Springer, 2017-03-30)Chronic neuropathic pain (CNP) is one of the most significant unmet clinical needs in modern medicine. Alongside the lack of effective treatments, there is a great deficit in the availability of objective diagnostic methods ... -
Differential role of anterior cingulate cortical glutamatergic neurons in pain-related aversion learning and nociceptive behaviors in male and female rats
Jarrin, Sarah; Pandit, Abhay; Roche, Michelle; Finn, David P. (Frontiers Media, 2020-08-11)Pain is comprised of both sensory and affective components. The anterior cingulate cortex (ACC) is a key brain region involved in the emotional processing of pain. Specifically, glutamatergic transmission within the ACC ... -
The effect of pain on cognitive function: a review of clinical and preclinical research.
Moriarty, Orla; McGuire, Brian E.; Finn, David P. (2011)Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical ... -
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats
Finn, David P.; Jhaveri, M.D.; Jhaveri, Maulik D.; Beckett, Simon Richard Graham; Roe, Clare H.; Kendall, David A.; Marsden, Charles Alexander; Chapman, Victoria (Elsevier, 2003-07-31)The analgesic potential of cannabinoids may be hampered by their ability to produce aversive emotion when administered systemically. We investigated the hypothesis that the midbrain periaqueductal grey (PAG) is a common ...