Browsing College of Medicine, Nursing and Health Sciences by Subject "DEPRESSION"
Now showing items 1-4 of 4
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Characterisation of peroxisome proliferator-activated receptor signalling in the midbrain periaqueductal grey of rats genetically prone to heightened stress, negative affect and hyperalgesia
(Elsevier, 2016-12-01)The stress-hyperresponsive Wistar-Kyoto (WRY) rat strain exhibits a hyperalgesic phenotype and is a useful genetic model for studying stress-pain interactions. Peroxisome proliferator-activated receptor (PPAR) signalling ... -
Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats
(SAGE Publications, 2019-09-12)Background: The combination of buprenorphine, a partial mu-opioid receptor agonist and a functional kappa-opioid receptor antagonist, with samidorphan, a functional mu-opioid receptor antagonist, is being developed as an ... -
Frontolimbic, frontoparietal, and default mode involvement in functional dysconnectivity in psychotic bipolar disorder
(Elsevier, 2019-11-11)BACKGROUND: Functional abnormalities, mostly involving functionally specialized subsystems, have been associated with disorders of emotion regulation such as bipolar disorder (BD). Understanding how independent functional ... -
Validation of an air-puff passive-avoidance paradigm for assessment of aversive learning and memory in rat models of chronic pain
(2012)Chronic pain is associated with cognitive deficits. Considerable overlap in brain regions involved in pain and aversion suggests that aversive learning and memory may be affected during chronic pain. Passive-avoidance ...