Now showing items 1-3 of 3

    • Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury 

      McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)
      Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ...
    • Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury 

      McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)
      Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ...
    • Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord 

      Donnelly, Eleanor M.; Madigan, Nicolas N.; Rooney, Gemma E.; Knight, Andrew; Chen, Bingkun; Ball, Bret; Kinnavane, Lisa; Garcia, Yolanda; Dockery, Peter; Fraher, John; Strappe, Padraig M.; Windebank, Anthony J.; O'Brien, Timothy; McMahon, Siobhan S. (Elsevier, 2012-01-08)
      Background aims. In this study we investigated the effect of neurotrophin-3 (NT-3) and knockdown of NG2, one of the main inhibitory chondroitin sulfate proteoglycans (CSPG), in the glial scar following spinal cord injury ...