Browsing College of Medicine, Nursing and Health Sciences by Author "Egan, Laurence J."
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Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor
Kerr, D.M.; Burke, N.N.; Ford, Gemma K.; Harhen, Brendan; Egan, Laurence J.; Finn, David P.; Roche, Michelle (Elsevier, 2011-09)The endocannabinoid system is an important regulator of the nervous, neuroendocrine, and immune systems, thus representing a novel therapeutic target for stress-related neuroinflammatory and psychiatric disorders. However, ... -
Stromal cell PD-L1iInhibits CD8(+) T-cell antitumor immune responses and promotes colon cancer
O'Malley, Grace; Treacy, Oliver; Lynch, Kevin; Naicker, Serika D.; Leonard, Niamh A.; Lohan, Paul; Dunne, Philip D.; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (American Association for Cancer Research, 2018-11)Stromal cells of mesenchymal origin reside below the epithelial compartment and provide structural support in the intestine. These intestinal stromal cells interact with both the epithelial cell compartments, as well as ...