Browsing College of Medicine, Nursing and Health Sciences by Author "Barry, Frank P."
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Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Moran, Cathal; Hynes, Jacqueline; Garcia, Yolanda; Dockery, Peter; O’Brien, Timothy; Windebank, Anthony J.; Barry, Frank P. (Wiley, 2009-08-20)Considerable evidence has shown that the immunosuppressant drug cyclosporin A (CsA) may have neuroprotective properties which can be exploited in the treatment of spinal cord injury. The aim of this study was to investigate ... -
Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury
McMahon, Siobhan S.; Albermann, Silke; Rooney, Gemma E.; Shaw, Georgina; Garcia, Yolanda; Sweeney, Eva; Hynes, Jacqueline; Dockery, Peter; O'Brien, Timothy; Windebank, Anthony J.; Allsopp, Timothy E.; Barry, Frank P. (Elsevier, 2012-12-20)Background aims. Spinal cord injury is a devastating injury that impacts drastically on the victim's quality of life. Stem cells have been proposed as a therapeutic strategy. Neural stem (NS) cells have been harvested from ... -
Hypoxia activates the PTHrP-MEF2C pathway to attenuate hypertrophy in mesenchymal stem cell derived cartilage
Browe, David C.; Coleman, Cynthia M.; Barry, Frank P.; Elliman, Stephen J. (Nature Research, 2019-09-16)Articular cartilage lacks an intrinsic repair capacity and due to the ability of mesenchymal stem cells (MSCs) to differentiate into chondrocytes, MSCs have been touted as a cellular source to regenerate damaged cartilage. ... -
Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation
Hogan, Niamh M.; Joyce, Myles R.; Murphy, J. Mary; Barry, Frank P.; O’Brien, Timothy; Kerin, Michael J.; Dwyer, Róisín M. (Elsevier, 2013-05-16)Mesenchymal Stem Cells are known to engraft and integrate into the architecture of colorectal tumours, with little known regarding their fate following engraftment. This study aimed to investigate mediators of Mesenchymal ...