Now showing items 16-27 of 27

    • Gene therapy in transplantation: Toward clinical trials 

      Ritter, Thomas (Thompson, 2009)
      The genetic modification of organs or cells is an attractive approach to protect allogeneic transplants from acute rejection and other complications. The transplant setting offers a unique opportunity to utilise ex vivo ...
    • Genetically Modified Mesenchymal Stem 

      Griffin, Matthew; Greiser, Udo; Barry, Frank; O'Brien, Timothy; Ritter, Thomas (2010-03)
      Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the ...
    • High-risk corneal transplantation: Recent developments and future possibilities 

      Armitage, W. John; Goodchild, Christine; Griffin, Matthew D.; Gunn, David J.; Hjortdal, Jesper; Lohan, Paul; Murphy, Conor C.; Pleyer, Uwe; Ritter, Thomas; Tole, Derek M.; Vabres, Bertrand (Lippincott, Williams & Wilkins, 2019-12)
      Human corneal transplantation (keratoplasty) is typically considered to have superior short- and long-term outcomes and lower requirement for immunosuppression compared to solid organ transplants because of the inherent ...
    • Immunogenicity of allogeneic mesenchymal stem cells 

      Ritter, Thomas (2012)
      Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ...
    • Inefficiency in macromolecular transport of SCS‐based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells 

      Sanz-Nogués, Clara; Horan, Jason; Thompson, Kerry; Howard, Linda; Ryan, Gerard; Kassem, Moustapha; O'Brien, Timothy (Wiley, 2015-05-01)
      Microcapsules made of sodium cellulose sulphate (SCS) and poly-diallyl-dimethyl-ammonium chloride (pDADMAC) have been employed to encapsulate a wide range of established cell lines for several applications. However, little ...
    • A novel high-throughput screening platform identifies itaconate derivatives from marine Penicillium antarcticum as inhibitors of mesenchymal stem cell differentiation 

      Marchese, Pietro; Mahajan, Nipun; O’Connell, Enda; Fearnhead, Howard; Tuohy, Maria; Krawczyk, Janusz; Thomas, Olivier P.; Barry, Frank; Murphy, Mary J. (MDPI, 2020-04-05)
      Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation. Current ...
    • Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment 

      von Muenchow, Lilly; Alberti-Servera, Llucia; Klein, Fabian; Capoferri, Giuseppina; Finke, Daniela; Ceredig, Rhodri; Rolink, Antonius; Tsapogas, Panagiotis (National Academy of Sciences, 2016-11-04)
      Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating ...
    • Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression 

      Connaughton, Eanna P.; Naicker, Serika; Hanley, Shirley A.; Slevin, Stephanie M.; Eykelenboom, John K.; Lowndes, Noel F.; O'Brien, Timothy; Ceredig, Rhodri; Griffin, Matthew D.; Dennedy, Michael C. (Wiley, 2018-03-05)
      Human blood monocytes are subclassified as classical, intermediate and nonclassical. In this study, it was shown that conventionally defined human intermediate monocytes can be divided into two distinct subpopulations with ...
    • Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice 

      von Muenchow, Lilly; Tsapogas, Panagiotis; Albertí-Servera, Llucia; Capoferri, Giuseppina; Doelz, Marianne; Rolink, Hannie; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley, 2016-12-28)
      Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free ...
    • The secretome derived from mesenchymal stromal cells cultured in a xeno-free medium promotes human cartilage recovery in vitro 

      Palama, Maria Elisabetta Federica; Shaw, Georgina Margaret; Carluccio, Simonetta; Reverberi, Daniele; Sercia, Laura; Persano, Luana; Pisignano, Dario; Cortese, Katia; Barry, Francis Peter; Murphy, Josephine Mary; Gentili, Chiara (Frontiers Media, 2020-02-14)
      Osteoarthritis (OA) is a disabling joint disorder causing articular cartilage degeneration. Currently, the treatments are mainly aimed to pain and symptoms relief, rather than disease amelioration. Human bone marrow stromal ...
    • Sterile post-traumatic immunosuppression 

      Islam, Md Nahidul; Bradley, Benjamin A.; Ceredig, Rhodri (Nature Publishing Group, 2016-04-29)
      After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ...
    • TGF-ß1-Licensed Murine MSCs show superior therapeutic efficacy in modulating corneal allograft immune rejection In Vivo 

      Lynch, Kevin; Treacy, Oliver; Chen, Xizhe; Murphy, Nick; Lohan, Paul; Islam, Md Nahidul; Donohoe, Ellen; Griffin, Matthew D.; Watson, Luke; McLoughlin, Steven; O'Malley, Grace; Ryan, Aideen E.; Ritter, Thomas (Elsevier, 2020-05-29)
      Mesenchymal stromal cells (MSCs) are a promising therapeutic option for multiple immune diseases/disorders; however, efficacy of MSC treatments can vary significantly. We present a novel licensing strategy to improve the ...