Now showing items 17-20 of 20

  • Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment 

    von Muenchow, Lilly; Alberti-Servera, Llucia; Klein, Fabian; Capoferri, Giuseppina; Finke, Daniela; Ceredig, Rhodri; Rolink, Antonius; Tsapogas, Panagiotis (National Academy of Sciences, 2016-11-04)
    Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating ...
  • Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression 

    Connaughton, Eanna P.; Naicker, Serika; Hanley, Shirley A.; Slevin, Stephanie M.; Eykelenboom, John K.; Lowndes, Noel F.; O'Brien, Timothy; Ceredig, Rhodri; Griffin, Matthew D.; Dennedy, Michael C. (Wiley, 2018-03-05)
    Human blood monocytes are subclassified as classical, intermediate and nonclassical. In this study, it was shown that conventionally defined human intermediate monocytes can be divided into two distinct subpopulations with ...
  • Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice 

    von Muenchow, Lilly; Tsapogas, Panagiotis; Albertí-Servera, Llucia; Capoferri, Giuseppina; Doelz, Marianne; Rolink, Hannie; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley, 2016-12-28)
    Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free ...
  • Sterile post-traumatic immunosuppression 

    Islam, Md Nahidul; Bradley, Benjamin A.; Ceredig, Rhodri (Nature Publishing Group, 2016-04-29)
    After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ...