Now showing items 17-22 of 22

    • Immunogenicity of allogeneic mesenchymal stem cells 

      Ritter, Thomas (2012)
      Mesenchymal stem cells (MSCs) inhibit proliferation of allogeneic T cells and express low levels of major histocompatibility complex class I (MHCI), MHCII and vascular adhesion molecule-1 (VCAM-1). We investigated whether ...
    • Inefficiency in macromolecular transport of SCS‐based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells 

      Sanz-Nogués, Clara; Horan, Jason; Thompson, Kerry; Howard, Linda; Ryan, Gerard; Kassem, Moustapha; O'Brien, Timothy (Wiley, 2015-05-01)
      Microcapsules made of sodium cellulose sulphate (SCS) and poly-diallyl-dimethyl-ammonium chloride (pDADMAC) have been employed to encapsulate a wide range of established cell lines for several applications. However, little ...
    • Permissive roles of cytokines Interleukin-7 and Flt3-ligand in mouse B cell lineage commitment 

      von Muenchow, Lilly; Alberti-Servera, Llucia; Klein, Fabian; Capoferri, Giuseppina; Finke, Daniela; Ceredig, Rhodri; Rolink, Antonius; Tsapogas, Panagiotis (National Academy of Sciences, 2016-11-04)
      Hematopoietic cells are continuously generated throughout life from hematopoietic stem cells, thus making hematopoiesis a favorable system to study developmental cell lineage commitment. The main factors incorporating ...
    • Phenotypic and functional heterogeneity of human intermediate monocytes based on HLA-DR expression 

      Connaughton, Eanna P.; Naicker, Serika; Hanley, Shirley A.; Slevin, Stephanie M.; Eykelenboom, John K.; Lowndes, Noel F.; O'Brien, Timothy; Ceredig, Rhodri; Griffin, Matthew D.; Dennedy, Michael C. (Wiley, 2018-03-05)
      Human blood monocytes are subclassified as classical, intermediate and nonclassical. In this study, it was shown that conventionally defined human intermediate monocytes can be divided into two distinct subpopulations with ...
    • Pro-B cells propagated in stromal cell-free cultures reconstitute functional B-cell compartments in immunodeficient mice 

      von Muenchow, Lilly; Tsapogas, Panagiotis; Albertí-Servera, Llucia; Capoferri, Giuseppina; Doelz, Marianne; Rolink, Hannie; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley, 2016-12-28)
      Up to now long-term in vitro growth of pro-B cells was thought to require stromal cells. However, here we show that fetal liver (FL) and bone marrow (BM) derived pro-B cells can be propagated long-term in stromal cell-free ...
    • Sterile post-traumatic immunosuppression 

      Islam, Md Nahidul; Bradley, Benjamin A.; Ceredig, Rhodri (Nature Publishing Group, 2016-04-29)
      After major trauma, the human immune system initiates a series of inflammatory events at the injury site that is later followed by suppression of local inflammation favoring the repair and remodeling of the damaged tissues. ...